{Reference Type}: Journal Article
{Title}: GI.1 Norovirus Neutralizing Antibody Levels Are Correlated with GI.1 Histo-blood Group Antigen-Blocking Antibody Levels.
{Author}: Atmar RL;Ettayebi K;Neill FH;Braun RP;Sherwood J;Ramani S;Estes MK;
{Journal}: J Infect Dis
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jun 12
{Factor}: 7.759
{DOI}: 10.1093/infdis/jiae311
{Abstract}: <B>BACKGROUND: </B>The in vitro cultivation of human noroviruses allows a comparison of antibody levels measured in neutralization and histoblood group antigen (HBGA)-blocking assays.<BR><B>METHODS: </B>Serum samples collected during the evaluation of an investigational norovirus vaccine (HIL-214 [formerly TAK-214]) were assayed for neutralizing antibody levels against the vaccine's prototype Norwalk virus/GI.1 (P1) virus strain. Results were compared to those previously determined using HBGA-blocking assays.<BR><B>RESULTS: </B>Neutralizing antibody seroresponses were observed in 83% of 24 vaccinated adults, and antibody levels were highly correlated (r=0.81, P<0.001) with those measured by HBGA-blocking.<BR><B>CONCLUSIONS: </B>GI.1-specific HBGA-blocking antibodies are a surrogate for neutralization of GI.1 norovirus.