■本荟萃分析的目的是研究高强度间歇训练(HIIT)对心血管疾病(CVD)高危人群的动脉僵硬度(AS)和血管功能的影响。
■我们对电子数据库中发表的随机对照试验(RCT)进行了全面搜索(PubMed,WebofScience,科克伦,Embase,和Ebsco)自成立以来一直持续到2023年10月,以评估HIIT对CVD高危人群的AS和血管功能的影响。计算加权平均差(WMD)和95%置信区间(95%CI),使用I2检验评估异质性。
■这项研究包括来自16项研究的661名参与者。HIIT显著降低了心血管疾病高危人群的脉搏波速度(PWV)[加权平均差(WMD),-0.62;95%CI,-0.86--0.38;P<0.00001]。亚组分析显示,每周进行HIIT程序2-3次,持续时间控制在40min内[2-3次,-0.67;95%CI,-0.93--0.41;P<0.00001;持续时间,≤40分钟,-0.66;95%CI,-0.91--0.41;P<0.00001]。HIIT显着降低收缩压(SBP,-5.43;95%CI,-8.82--2.04;P=0.002),舒张压(DPB,-2.96;95%CI,-4.88--1.04;P=0.002),和静息心率(RHR,-4.35;95%CI,-7.04--1.66;P=0.002),但对增强指数没有显著影响(AIX,-2.14;95%CI,-6.77-2.50;P=0.37)。
■HIIT可以改善心血管疾病高危人群的PWV并降低SBP,DBP,和RHR,但对AIX没有显著影响。HIIT可有效改善AS和血管功能,可作为改善CVD高危人群AS的有效方法。
■https://www.crd.约克。AC.英国/PROSPERO/,标识符:CRD42023471593。
UNASSIGNED: The purpose of this meta-analysis was to investigate the effect of high-intensity interval training (HIIT) on arterial stiffness (AS) and vascular function in persons at high risk of cardiovascular disease (CVD).
UNASSIGNED: We conducted a comprehensive search of randomized controlled trials (RCTs) published in electronic databases (PubMed, Web of Science, Cochrane, Embase, and Ebsco) since their inception through October 2023 to evaluate the effect of HIIT on AS and vascular function in persons at high risk for CVD. The weighted mean difference (WMD) and 95% confidence intervals (95% CI) were calculated, and heterogeneity was assessed using the I2 test.
UNASSIGNED: This study included 661 participants from 16 studies. HIIT significantly reduced pulse wave velocity (PWV) in persons at high risk for CVD [weighted mean difference (WMD), -0.62; 95% CI, -0.86--0.38; P < 0.00001]. Subgroup analysis showed that the PWV improvement effect was better when the HIIT program was performed 2-3 times per week and the duration was controlled within 40 min [2-3 times, -0.67; 95% CI, -0.93--0.41; P < 0.00001; time of duration, ≤40 min, -0.66; 95% CI, -0.91--0.41; P < 0.00001]. HIIT significantly reduced systolic blood pressure (SBP, -5.43; 95% CI, -8.82--2.04; P = 0.002), diastolic blood pressure (DPB, -2.96; 95% CI, -4.88--1.04; P = 0.002), and resting heart rate (RHR, -4.35; 95% CI, -7.04--1.66; P = 0.002), but had no significant effect on augmentation index (AIX, -2.14; 95% CI, -6.77-2.50; P = 0.37).
UNASSIGNED: HIIT can improve PWV in high-risk individuals with CVD and reduce SBP, DBP, and RHR, but has no significant effect on AIX. HIIT can effectively improve AS and vascular function and can be recommended as an effective method to improve AS in high-risk persons with CVD.
UNASSIGNED: https://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42023471593.