肝病,每年造成两百万人死亡,导致慢性肝病(CLD)和肝硬化,每年造成大约一百万人死亡。肝毒性引起的肝损伤的治疗选择各不相同,包括药物(N-乙酰半胱氨酸,皮质类固醇,和熊去氧胆酸),生活方式的改变,有时还有肝移植.然而,效果各不相同,一些治疗有风险和副作用,强调需要改进的治疗方法。Murrayakoenigii(MK)以其肝脏保护而闻名,抗氧化剂,抗炎,抗微生物,肾保护,保肝,胃保护,心脏保护,神经保护,伤口愈合,抗癌和免疫调节作用,等。这篇综述强调了MK对重金属诱导的肝损伤的有效性,药物滥用,外源性物质,等。跨PubMed等多个数据库的全面搜索,谷歌学者,以及其他有关MK的各种肝毒性和肝保护活性的文章。研究人员应用了特定的搜索条件和限制,产生149篇合格的文章供最终分析,符合预定的纳入标准,排除不相关的研究。根据现有文献,MK的植物化学成分,如类黄酮,单宁,和各种提取物中存在的生物碱,通过改变氧化和内质网应激在逆转肝毒性作用中起关键作用,重新建立肝脏生化标志物和参与代谢的酶,表示改善活性,并控制促炎细胞因子的表达。最后,这篇综述强调了MK作为天然肝脏保护剂的巨大潜力,为重金属造成的一系列伤害提供多功能防御,外源性物质,和常见的肝毒性药物。
Liver disease, responsible for two million annual deaths, causes Chronic Liver Disease (CLD) and cirrhosis, causing roughly a million deaths yearly. Treatment options for liver injury induced by hepatotoxicity vary, including medication (N-acetylcysteine, corticosteroids, and ursodeoxycholic acid), lifestyle changes, and sometimes liver transplant. However, effectiveness varies, and some treatments carry risks and side effects, highlighting the need for improved therapeutic approaches. Murraya koenigii (MK) is known for its
hepatoprotective, antioxidant, anti-inflammatory, anti-microbial, nephroprotective,
hepatoprotective, gastroprotective, cardioprotective, neuroprotective, wound-healing, anti-cancerous and immunomodulatory effects, etc. This review highlights the effectiveness of MK against liver damage induced by heavy metals, drug abuse, xenobiotics, etc. A comprehensive search across multiple databases like PubMed, Google Scholar, and others for articles on various hepatotoxicants and
hepatoprotective activity of MK was conducted. The researchers applied specific search terms and limits, resulting in 149 eligible articles for final analysis, meeting predetermined inclusion criteria and excluding irrelevant studies. According to the available literature, the phytochemical components of MK, such as flavonoids, tannins, and alkaloids present in various extracts, play a crucial role in reversing the hepatotoxic effects by modifying oxidative and ER stresses, re-establishing the hepatic biochemical markers and enzymes involved in metabolism denoting ameliorative activity, and controlling the expression of pro-inflammatory cytokines. To conclude, this review highlights that MK has great potential as a natural
hepatoprotective agent, providing a versatile defense against a range of injuries caused by heavy metals, xenobiotics, and common hepatotoxic agents.