UNASSIGNED:夜间吃零食是一种有效的干预措施,可避免因长时间禁食而导致蛋白质消耗异常。本文旨在评价夜间吃零食对乙型肝炎肝硬化患者的临床疗效,为临床营养干预提供新思路。
UNASSIGNED:将研究参与者随机分为对照组(n=30)和观察组(n=30);前者给予医疗系统治疗和常规饮食干预,后者给予相同的治疗,并增加夜间零食。经过3个月的不同饮食指导干预,干体重体重指数(BMI),上臂肌围(AMC),握力,三头肌皮褶厚度(TSF),第三腰骨骼肌指数(L3-SMI),白蛋白(ALB),总胆红素(T-BIL),胆碱酯酶(CHE),Fried的脆弱表型评分,比较两组Child-Pugh评分及各种肝硬化并发症发生率。
UNASSIGNED:饮食干预前两组之间的基线数据没有显着差异。对照组在常规饮食指导3个月后,与基线数据相比,握力增加(p<0.05),而干重BMI,AMC,TSF,L3-SMI,ALB,T-BIL,CHE,凝血酶原时间,国际标准化比率,凝血酶原活性,Child-Pugh评分差异无统计学意义(p>0.05)。观察组经过3个月的饮食指导配合夜间吃零食,干重BMI,握力,TSF,L3-SMI,CHE的分数都增加了,与基线数据相比,而Child-Pugh评分较基线水平下降(均p<0.05)。经过3个月的干预,观察组Child-Pugh评分较对照组下降更明显,而干重BMI,握力,ALB和CHE评分均显著高于对照组(均p<0.05)。总的来说,观察组改善率明显高于对照组(p<0.05)。
UNASSIGNED:对于有营养风险的乙型肝炎肝硬化患者,夜间吃零食有利于肝脏合成功能的恢复,临床指标的改善,肌肉减少症的矫正和营养不良相关并发症的改善。
UNASSIGNED: Nighttime snacking is an effective intervention to avoid abnormal protein consumption caused by prolonged fasting. This article aims to evaluate the clinical efficacy of nighttime snacking on patients with hepatitis B cirrhosis and to provide new ideas for clinical nutritional intervention.
UNASSIGNED: The study participants were randomly assigned to the control group (n = 30) and the observation group (n = 30); the former was administered medical system treatment and routine dietary intervention, and the latter was administered the same treatment with the addition of nighttime snacking. After 3 months of intervention with different dietary guidance, the dry body weight body mass index (BMI), upper arm muscle circumference (AMC), grip strength, triceps skinfold thickness (TSF), third lumbar skeletal muscle index (L3-SMI), albumin (ALB), total bilirubin (T-BIL), cholinesterase (CHE), Fried\'s frailty phenotype score, Child-Pugh score and various cirrhosis complication rates were compared between the two groups.
UNASSIGNED: There was no significant difference in the baseline data between the two groups before the dietary intervention. After 3 months of regular dietary guidance in the control group, the grip strength increased compared with the baseline data (p < 0.05), while the dry body weight BMI, AMC, TSF, L3-SMI, ALB, T-BIL, CHE, prothrombin time, international normalized ratio, prothrombin activity, and Child-Pugh scores were not significantly different (p > 0.05). After 3 months of dietary guidance with nighttime snacking in the observation group, the dry body weight BMI, grip strength, TSF, L3-SMI, and CHE scores all increased, compared with the baseline data, while the Child-Pugh score decreased compared with the baseline level (all p < 0.05). After 3 months of intervention, the Child-Pugh score of the observation group showed a more significant decrease than the control group, while the dry body weight BMI, grip strength, ALB and CHE scores were all significantly higher than those in the control group (all p < 0.05). Overall, the improvement rate was significantly higher in the observation group than in the control group (p < 0.05).
UNASSIGNED: Nighttime snacking for hepatitis B cirrhosis patients with nutritional risk is beneficial in terms of the recovery of liver synthesis functions, improvements in clinical indicators, sarcopenia corrections and improvements in malnutrition-related complications.