■童年家庭环境与成年期健康行为和心血管健康有关,但是关于儿童期家庭环境与成年期血压的血流动力学决定因素之间关系的数据有限。我们评估了儿童期家庭环境如何预测成年期系统血液动力学。
■样本来自YoungFinns研究中的心血管风险(n=1554-1620)。童年家庭环境(1980)用四个累积风险分数进行评估:社会经济家庭风险,危险的情感家庭氛围,紧张的生活事件,和父母危险的健康行为。2007年的血流动力学结果(参与者为30-45岁)包括每搏输出量指数,全身血管阻力指数,心输出量指数和心率。对儿童(1980年)心血管危险因素(高密度脂蛋白和低密度脂蛋白胆固醇,甘油三酯,胰岛素,体重指数和收缩压);和成年期(2007年)健康行为(饮酒,吸烟,体力活动);最后是成年期心血管危险因素。
■当根据年龄和性别进行调整时,高社会经济家庭风险预测较低的中风量指数(P=0.001),较高的心率(P=0.001)和较高的全身血管阻力指数(P=0.030)。这些关联在控制了儿童心血管协变量或成年期健康行为后仍然存在(全部P0.02),但在控制了成年期心血管危险因素后被稀释。其他童年累积风险评分(压力性生活事件,危险的情绪氛围,或父母的危险健康行为)不能预测成年后的血液动力学结果。
■高儿童社会经济家庭风险预测成年期血流动力学结果,与儿童心血管危险因素和成年期健康行为无关,而其他儿童心理社会逆境与成年期的心血管功能无关。
UNASSIGNED: Childhood family environment is associated with adulthood health behaviours and cardiovascular health, but limited data are available concerning the relationship between childhood family environment and adulthood haemodynamic determinants of blood pressure. We evaluated how childhood family environment predicts adulthood systemic
haemodynamics.
UNASSIGNED: The sample came from the Cardiovascular Risk in Young Finns Study (n=1554-1620). Childhood family environment (1980) was assessed with four cumulative risk scores: socioeconomic family risk, risky emotional family atmosphere, stressful life events, and parents\' risky health behaviours. Haemodynamic outcomes in 2007 (participants being 30-45 year-olds) included stroke volume index, systemic vascular resistance index, cardiac output index and heart rate. Analyses were adjusted for childhood (1980) cardiovascular risk factors (high-density lipoprotein and low-density lipoprotein cholesterol, triglycerides, insulin, body mass index and systolic blood pressure); and adulthood (2007) health behaviours (alcohol consumption, smoking, physical activity); and finally for adulthood cardiovascular risk factors.
UNASSIGNED: When adjusted for age and sex, high socioeconomic family risk predicted lower stroke volume index (P=0.001), higher heart rate (P=0.001) and higher systemic vascular resistance index (P=0.030). These associations remained after controlling for childhood cardiovascular covariates or adulthood health behaviours (P⩽0.02 for all) but diluted after controlling for adulthood cardiovascular risk factors. The other childhood cumulative risk scores (stressful life events, risky emotional atmosphere, or parents\' risky health behaviour) did not predict adulthood haemodynamic outcomes.
UNASSIGNED: High childhood socioeconomic family risk predicted adulthood haemodynamic outcomes independently of childhood cardiovascular risk factors and adulthood health behaviours, while other childhood psychosocial adversities were not associated with cardiovascular function in adulthood.