Abstract：
To effectively treat cerebral arteriovenous malformations (AVMs), peri-nidal flow regulation and metabolic status must be understood. In this study, we used 15O-oxygen positron emission tomography (PET) post-processing analysis to investigate vascular radioactivity in the nidal region of AVMs. Single-dynamic PET imaging was performed on seven unruptured AVM patients during the sequential inhalation of 15O2 and C15O2. A previously validated dual-tracer basis function method (DBFM) was employed to calculate parametric images. The results of our study were as follows. First, in remote and contralateral AVM regions, DBFM and a previous approach of dual-tracer autoradiography (DARG) showed strong positive correlations in cerebral blood flow (CBF), cerebral oxygen metabolism rate (CMRO2), and oxygen extraction fraction. Second, peri-nidal CBF and CMRO2 correlation was lower, and overestimation occurred with DARG compared to with DBFM. Third, on comparing DBFM to quantitative 123I-iodoamphetamine single-photon emission computed tomography (SPECT), CBF correlated significantly. In contrast, the correlation between DARG and quantitative 123I-iodoamphetamine-SPECT was weaker in the peri-nidal regions. Fourth, analysis of tissue time-activity curves demonstrated good reproducibility using the novel formulation in the control, peri-nidus, and core nidal regions, indicating the adequacy of this approach. Overall, the DBFM approach holds promise for assessing haemodynamic alterations in patients with AVMs.
摘要：
为了有效治疗脑动静脉畸形（AVM），必须了解外周流动调节和代谢状态。在这项研究中,我们使用15O-氧正电子发射断层扫描（PET）后处理分析来研究AVMnidal区域的血管放射性。在连续吸入15O2和C15O2的过程中，对7名未破裂的AVM患者进行了单动态PET成像。采用先前验证的双示踪剂基函数方法（DBFM）来计算参数图像。我们的研究结果如下。首先,在偏远和对侧AVM地区，DBFM和先前的双示踪剂放射自显影（DARG）方法在脑血流量（CBF）中显示出强正相关，脑氧代谢率（CMRO2），和氧提取分数。第二,外周CBF和CMRO2相关性较低，与DBFM相比，DARG出现了高估。第三，将DBFM与定量的123I-碘苯丙胺单光子发射计算机断层扫描（SPECT）进行比较，CBF显著相关。相比之下,DARG与定量123I-碘苯丙胺-SPECT之间的相关性在周围区域较弱。第四，对组织时间-活性曲线的分析显示，在对照中使用新型制剂具有良好的可重复性，peri-nidus,和核心区域，表明这种方法的充分性。总的来说,DBFM方法有望用于评估AVM患者的血流动力学改变。
