未经评估:大多数报告垂体后叶肿瘤(PPTs)的研究都是小病例系列或单个病例。
UNASSIGNED:确定了2010年1月至2021年12月在三级中心进行PPT组织学诊断的患者。我们报告了临床症状,内分泌评估,放射学和病理学特征,和PPTs的手术结果。
未经批准:共有51名患者(23名男性,本研究包括51.3±10.3岁)的PPT。主要症状是视觉缺陷,头痛,和垂体功能减退,而尿崩症并不常见(9.8%)。典型的放射学特征是在T1对比成像上均匀增强(84.3%)规则形状的肿块,而没有囊性改变。钙化,或海绵窦侵入。我们在38/51例患者中实现了总切除(74.5%)。病理上,所有肿瘤均显示甲状腺转录因子1免疫反应性。在29例鞍上PPTs患者中,经颅组有2/15例,内镜组有0/14例。梭形细胞嗜酸细胞瘤(SCO)患者更有可能接受手术治疗(25%vs0%,P=0.018),具有较高的Ki-67指数(16.7%vs0%>5%P=0.050),与垂体细胞瘤或颗粒细胞瘤患者相比,2年无复发生存率较低(67.5%vs90.9%)。
UNASSIGNED:对于鞍区和鞍上肿块具有均匀增强的规则病变的患者,应考虑PPTs的鉴别诊断。SCOs具有较高的增殖活性和复发风险。
UNASSIGNED: Most studies reporting posterior pituitary tumors (PPTs) are small case series or single cases.
UNASSIGNED: Patients with a histological diagnosis of PPT from January 2010 to December 2021 in a tertiary center were identified. We reported clinical symptoms, endocrine assessments, radiological and pathological features, and surgical outcomes of PPTs.
UNASSIGNED: A total of 51 patients (23 males, 51.3 ± 10.3 years old) with PPT were included in this study. Major symptoms were visual defects, headache, and hypopituitarism, while diabetes insipidus was uncommon (9.8%). The typical radiological feature was homogeneous enhancement (84.3%) of a regular-shaped mass on T1 contrast imaging without cystic change, calcification, or cavernous sinus invasion. We achieved gross total resection in 38/51 patients (74.5%). Pathologically, all tumors showed thyroid transcription factor 1 immunoreactivity. Among 29 patients with suprasellar PPTs, postoperative hemorrhage due to tumor residue was encountered in 2/15 cases in the transcranial group and 0/14 in the endoscopy group. Patients with spindle cell oncocytoma (SCO) were more likely to be surgically treated (25% vs 0%, P = 0.018), harbor a higher Ki-67 index (16.7% vs 0% > 5% P = 0.050), and present a lower 2-year recurrence-free survival rate (67.5% vs 90.9%) compared with patients with pituicytoma or granular cell tumor.
UNASSIGNED: PPTs should be considered in the differential diagnosis of patients with sellar and suprasellar masses with a regular lesion with homogeneous enhancement. SCOs had high proliferation activity and risk of recurrence.