PDF(Pubmed)
Abstract：
Granular cell tumors (GCTs) are neoplasms of uncertain histopathological etiology and therefore there are no universally accepted treatment strategies. GCTs are characterized by abundant eosinophilic granules. Since they are predominantly located in the skin and subcutaneous tissues, gastric GCTs are exceedingly rare. The present study documents the case of a 52-year-old man who visited the Gastroenterology Clinic of the People\'s Hospital of Putuo District (Zhoushan, China) due to upper abdominal fullness. Endoscopic ultrasonography revealed a well-defined hypoechoic nodule in the submucosal layer of the stomach body. The lesion was completely excised using endoscopic submucosal dissection and the patient made a full postoperative recovery. Immunohistochemistry showed positivity for S100 and CD68, with CD34 expression surrounding the tumor cells. At telephone follow-up until May 2024, the patient\'s fullness and discomfort were noted to be relieved. The characteristics of the CD34 expression pattern may serve as a novel basis for the pathological diagnosis of gastric GCTs. Endoscopic resection is a feasible option for gastric GCTs smaller than 2 cm.
摘要：
颗粒细胞瘤（GCTs）是组织病理学病因不确定的肿瘤，因此没有普遍接受的治疗策略。GCTs的特征在于丰富的嗜酸性颗粒。由于它们主要位于皮肤和皮下组织中，胃GCT非常罕见。本研究记录了一名52岁男子在普陀区人民医院胃肠病门诊就诊的病例（舟山，中国）由于上腹部丰满。内窥镜超声检查显示胃体粘膜下层有一个清晰的低回声结节。使用内镜粘膜下剥离术将病变完全切除，患者术后完全康复。免疫组织化学显示S100和CD68阳性，肿瘤细胞周围有CD34表达。在直到2024年5月的电话随访中，患者的饱腹感和不适感得到缓解。CD34表达模式的特征可能为胃GCT的病理诊断提供新的依据。对于小于2cm的胃GCTs，内镜切除是一种可行的选择。
