Adropin是一种由能量稳态相关基因编码的分泌肽,它也起着促进细胞间通讯的膜结合蛋白的作用。这种肽已经在各种组织和体液中被检测到,包括大脑,肝脏,肾,心,胰腺,小肠,内皮细胞和初乳。值得注意的是,adropin的氨基酸序列在人类中是相同的,老鼠和老鼠。先前的研究表明,阿托品水平在不同的生理和病理条件下波动。Adropin在调节碳水化合物代谢中起作用,脂质代谢和细胞间分子信号通路,它参与了许多疾病的发展,比如急性心肌梗塞,肺损伤,非酒精性脂肪性肝病/非酒精性脂肪性肝炎,肾病,多囊卵巢综合征,肥胖,糖尿病,动脉粥样硬化,系统性硬化症和癌症。尽管意义重大,该蛋白质的确切作用和机制仍未得到充分理解和研究。阐明阿托品的功能及其临床研究现状,我们对最近关于adropin在各种疾病中的研究进行了系统综述.此外,确定了与动物和临床环境中的adropin研究相关的几个挑战和局限性,旨在为未来的调查提供有价值的见解。
Adropin is a secreted peptide encoded by the energy homeostasis‑associated gene, which also functions as a membrane‑bound protein facilitating intercellular communication. This peptide has been detected in various tissues and body fluids, including the brain, liver, kidney, heart, pancreas, small intestine, endothelial cells and colostrum. Notably, the amino acid sequences of adropin are identical in humans, mice and rats. Previous studies have demonstrated that adropin levels fluctuate under different physiological and pathological conditions. Adropin plays a role in regulating carbohydrate metabolism, lipid metabolism and intercellular molecular signaling pathways, implicating its involvement in the progression of numerous diseases, such as acute myocardial infarction, lung injury, non‑alcoholic fatty liver disease/non‑alcoholic steatohepatitis, kidney disease, polycystic ovary syndrome, obesity, and diabetes, atherosclerosis, systemic sclerosis and cancer. Despite its significance, the precise role and mechanism of this protein remain inadequately understood and studied. To elucidate the function of adropin and its clinical research status, a systematic review of recent studies on adropin across various diseases was conducted. Additionally, several challenges and limitations associated with adropin research in both animal and clinical contexts were identified, aiming to offer valuable insights for future investigation.