背景胃肠道间质瘤(GIST)是胃肠道最常见的间质瘤,来自Cajal的间质细胞.这些肿瘤桥接神经系统和胃肠道的肌肉层,在消化过程中起着至关重要的作用。GIST的发生率显示出不同种族和族裔群体的显着差异,强调需要深入分析以了解遗传的相互作用,环境,以及这些差距背后的社会经济因素。线性回归分析是此类流行病学研究中的关键统计工具,提供对疾病发病率的时间动态和公共卫生干预的影响的见解。方法这项调查采用了2009年至2020年的详细数据集,记录了亚洲的GIST发生率,非洲裔美国人,西班牙裔,白人人口。细致的预处理程序准备了数据集以进行分析,涉及数据清理,种族术语的正常化,按年份和种族划分。线性回归模型和皮尔逊相关系数用于分析不同种族群体GIST发病率的趋势和相关性。强调对疾病发病率的时间模式和种族差异的理解。结果本研究分析了四个种族群体的GIST病例,显示男性占主导地位(53.19%),并且在种族类别中的病例分布均匀:白人(27.66%),西班牙裔(25.53%),非洲裔美国人(24.47%),和亚洲人(22.34%)。高血压是最常见的合并症(32.98%),其次是心力衰竭(28.72%)。亚洲人的线性回归分析显示GIST发生率呈下降趋势,斜率为-0.576,R平方值为0.717,无显著p值为0.153。观察到白人的显着增加趋势,斜率为0.581,R平方值为0.971,p值为0.002。非裔美国人表现出0.277的中等正斜率,R平方值为0.470,p值为0.201,表明没有显着增加。西班牙裔随时间的变化可忽略不计,斜率为-0.095,R平方值为0.009,p值为0.879,表明没有显着趋势。结论本研究调查了跨种族群体的GIST发生率,揭示了巨大的差距。白人呈增加趋势(p=0.002),虽然亚洲人显示出下降趋势(p=0.153),非洲裔美国人和西班牙裔美国人的利率稳定。这种差异表明了遗传学的复杂相互作用,环境,和社会经济因素,强调需要有针对性的研究和干预措施,以解决这些差异和影响GIST结果的系统性不平等。
Background Gastrointestinal stromal tumors (GISTs) represent the most common mesenchymal neoplasms of the gastrointestinal tract, arising from the interstitial cells of Cajal. These tumors bridge the nervous system and muscular layers of the gastrointestinal tract, playing a crucial role in the digestive process. The incidence of GISTs demonstrates notable variations across different racial and ethnic groups, underscoring the need for in-depth analysis to understand the interplay of genetic, environmental, and socioeconomic factors behind these disparities. Linear regression analysis is a pivotal statistical tool in such epidemiological studies, offering insights into the temporal dynamics of disease incidence and the impact of public health interventions. Methodology This investigation employed a detailed dataset from 2009 to 2020, documenting
GIST incidences across Asian, African American, Hispanic, and White populations. A meticulous preprocessing routine prepared the dataset for analysis, which involved data cleaning, normalization of racial terminologies, and aggregation by year and race. Linear regression models and Pearson correlation coefficients were applied to analyze trends and correlations in GIST incidences across the different racial groups, emphasizing an understanding of temporal patterns and racial disparities in disease incidence. Results The study analyzed
GIST cases among four racial groups, revealing a male predominance (53.19%) and an even distribution of cases across racial categories: Whites (27.66%), Hispanics (25.53%), African Americans (24.47%), and Asians (22.34%). Hypertension was the most common comorbidity (32.98%), followed by heart failure (28.72%). The linear regression analysis for Asians showed a decreasing trend in
GIST incidences with a slope of -0.576, an R-squared value of 0.717, and a non-significant p-value of 0.153. A significant increasing trend was observed for Whites, with a slope of 0.581, an R-squared value of 0.971, and a p-value of 0.002. African Americans exhibited a moderate positive slope of 0.277 with an R-squared value of 0.470 and a p-value of 0.201, indicating a non-significant increase. Hispanics showed negligible change over time with a slope of -0.095, an R-squared value of 0.009, and a p-value of 0.879, suggesting no significant trend. Conclusions This study examines
GIST incidences across racial groups, revealing significant disparities. Whites show an increasing trend (p = 0.002), while Asians display a decreasing trend (p = 0.153), with stable rates in African Americans and Hispanics. Such disparities suggest a complex interplay of genetics, environment, and socioeconomic factors, highlighting the need for targeted research and interventions that address these differences and the systemic inequalities influencing
GIST outcomes.