PDF(Pubmed)
Abstract：
Background: Gastric gastrointestinal stromal tumors (GISTs) represent a subset of gastrointestinal tumors predominantly found in the stomach. Despite their rarity, these tumors carry significant implications for patient health and management. GISTs are potentially malignant tumors with unpredictable progression. They originate from the interstitial cells of Cajal, which are positioned between the intramural neurons and the smooth muscle cells of the digestive tract. These tumors are characterized primarily by mutations in the c-Kit gene, as well as other mutations such as those in the platelet-derived growth factor receptor alpha (PDGFRA) gene. Methods: Our comprehensive search across five databases initially yielded 2976 articles. After eliminating 197 duplicates, we screened the titles and abstracts of 2779 articles, excluding 2692 for not meeting the inclusion criteria. During the full-text screening, 16 more articles were excluded. Ultimately, 71 papers met the inclusion criteria and were included in our analysis. Results: Due to differences in study designs, inclusion criteria for patients, and reported outcomes, a meta-analysis was not conducted. The accurate diagnosis of GIST is established through histopathological examination and immunohistochemistry. Histopathologically, GISTs are classified into three main types: spindle cell, epithelioid, and mixed. The therapeutic management of GIST involves surgery, endoscopic treatment, and chemotherapy. Conclusions: The prognosis for GIST patients depends on various factors, including risk category, disease stage, applied treatments, and recurrence post-treatment. A significant recent advancement comes from artificial intelligence, which can be increasingly involved in both the diagnosis and treatment of this tumor.
摘要：
背景：胃胃肠道间质瘤（GIST）代表主要在胃中发现的胃肠道肿瘤的子集。尽管它们很少,这些肿瘤对患者的健康和管理具有重要意义.GIST是具有不可预测的进展的潜在恶性肿瘤。它们起源于Cajal的间质细胞,它们位于消化道的壁内神经元和平滑肌细胞之间。这些肿瘤的主要特征是c-Kit基因突变，以及其他突变，例如血小板衍生生长因子受体α（PDGFRA）基因的突变。方法：我们在五个数据库中的全面搜索最初产生了2976篇文章。消除197个重复项之后，我们筛选了2779篇文章的标题和摘要，不符合纳入标准的2692人除外。在全文筛选过程中,另有16篇文章被排除在外。最终,71篇论文符合纳入标准，被纳入我们的分析。结果：由于研究设计的差异，患者的纳入标准，和报告的结果，未进行荟萃分析.通过组织病理学检查和免疫组织化学建立GIST的准确诊断。组织病理学,GIST分为三种主要类型：梭形细胞，上皮样，和混合。GIST的治疗包括手术，内镜治疗,和化疗。结论:GIST患者的预后取决于多种因素,包括风险类别，疾病阶段,应用治疗，治疗后复发。人工智能最近取得了重大进展，它可以越来越多地参与这种肿瘤的诊断和治疗。
