■有人提出了COVID-19大流行对头颈癌(HNC)的影响,但因果关系尚不清楚。
■我们利用孟德尔随机化(MR)方法探索了这种联系,该方法应用于COVID-19和HNC的公开全基因组关联研究(GWAS)摘要数据集。数据集包括关键的COVID-19(13,769例,1,072,442个控件),住院COVID-19(32,519例,2,062,805个控件),SARS-CoV-2感染(122,616例,2,475,240个控件),和HNC(2,131例,287,137个控件)。通过基于AI的文献数据挖掘增强的功能注释,探索了通过MR分析确定的因果关系的机理基础。
■令人惊讶的是,感染较温和形式的COVID-19的遗传易感性大大降低了发展为HNC的风险(OR:0.52,95%CI:0.35-0.78,p=1.42E-03),严重COVID-19的遗传倾向与检测到的HNC风险之间没有显着关联。此外,我们的发现强调了与SARS-CoV-2感染相关的14个基因,在HNC的背景下可能发挥保护作用。这些基因包括OAS1,LOC107985887,BCL11A,DPP9,LOC107984685,LINC02326,MUC4,NXPE3,IFNAR2,LZTFL1,LOC105372437,NAPSA,LOC105376622、LOC107986082和SLC6A20。
■我们的研究强调了温和COVID-19的遗传倾向在降低HNC风险方面的保护作用,同时驳斥了严重COVID-19与HNC之间的因果关系。
UNASSIGNED: The impact of the COVID-19 pandemic on head and neck cancer (HNC) has been suggested, but the causal relationship remains unclear.
UNASSIGNED: We explore this connection by utilizing the Mendelian randomization (MR) approach applied to publicly available genome-wide association study (GWAS) summary datasets for COVID-19 and HNC. The datasets included critical COVID-19 (13,769 cases, 1,072,442 controls), hospitalized COVID-19 (32,519 cases, 2,062,805 controls), SARS-CoV-2 infection (122,616 cases, 2,475,240 controls), and HNC (2,131 cases, 287,137 controls). Mechanistic underpinnings of the causal relationships identified by MR analysis were explored through functional annotation augmented by AI-based literature data mining.
UNASSIGNED: Surprisingly, a genetic predisposition to contracting a milder form of COVID-19 substantially reduced the risks of developing HNC (OR: 0.52, 95% CI: 0.35-0.78, p = 1.42E-03), with no significant association between genetic liability to severe COVID-19 and the risk of HNC detected. Additionally, our findings highlighted 14 genes linked to SARS-CoV-2 infection, potentially playing a protective role in the context of HNC. These genes include OAS1, LOC107985887, BCL11A, DPP9, LOC107984685, LINC02326, MUC4, NXPE3, IFNAR2, LZTFL1, LOC105372437, NAPSA, LOC105376622, LOC107986082, and SLC6A20.
UNASSIGNED: Our study emphasizes the protective role of the genetic liability to milder COVID-19 in reducing the risk of HNC while refuting a causal relationship between severe COVID-19 and HNC.