目的:已知某些患者多次暴露于基于g的造影剂(GBCA)与g在大脑中的沉积有关。这种沉积与特定的脑部MRI发现相关,尽管大多数可用的数据是患有基础神经系统疾病的患者。我们旨在前瞻性评估接受乳腺MRI筛查的女性的脑MRI信号变化以及神经系统和神经心理学测试结果。
方法:在此IRB批准的,符合HIPAA的前瞻性研究,9名因筛查乳腺MRI而暴露于线性和/或大环GBCA5次或更多次的女性接受了非对比脑MRI检查,神经系统检查和神经心理测试。有潜在神经系统的女性,心理学,肝脏或肾脏疾病被排除.
结果:GBCA暴露的平均总数为8(标准偏差2.7),63/72(87%)的暴露是线性剂。脑MRI信号变化与神经系统或神经心理学检查异常之间没有关联。GBCA暴露总数与神经系统或神经心理学检查异常之间没有关联。
结论:在这项前瞻性探索性研究中,9名女性因筛查乳腺MRI而暴露于5次或更多GBCA,脑MRI信号改变与神经或神经心理检查的临床异常之间没有关联.虽然在这个患者人群中需要更大的研究,在这项研究中,多重GBCA暴露缺乏临床影响,这让人放心.
OBJECTIVE: Multiple exposures to gadolinium-based contrast agents (GBCAs) is known to be associated with gadolinium deposition in the brain in certain patients. Such deposition has been correlated with specific brain MRI findings, although most available data is in patients with underlying neurologic disorders. We aim to prospectively evaluate brain MRI signal changes as well as neurologic and neuropsychologic testing results in women undergoing screening breast MRI.
METHODS: In this IRB-approved, HIPAA-compliant prospective study, 9 women with 5 or more exposures to linear and/or macrocyclic GBCA due to screening breast MRI underwent noncontrast brain MRI, neurologic exam and neuropsychologic testing. Women with underlying neurologic, psychologic, hepatic or renal disorders were excluded.
RESULTS: The mean total number of GBCA exposures was 8 (standard deviation 2.7), with 63/72 (87%) of the exposures being linear agents. There was no association between brain MRI signal changes and abnormalities on neurologic or neuropsychologic examination. There was no association between total number of GBCA exposures and abnormalities on neurologic or neuropsychologic examination.
CONCLUSIONS: In this prospective exploratory study of 9 women with 5 or more GBCA exposures due to screening breast MRI, there was no association between brain MRI signal changes and clinical abnormalities on neurologic or neuropsychologic examination. While larger studies are needed in this patient population, the lack of clinical impact of multiple GBCA exposures in this study is reassuring.