PDF(Pubmed)
Abstract：
Gadolinium-based contrast agents (GBCAs) have helped to improve the role of magnetic resonance imaging (MRI) for the diagnosis and treatment of diseases. There are currently nine different commercially available gadolinium-based contrast agents (GBCAs) that can be used for body MRI cases, and which are classifiable according to their structures (cyclic or linear) or biodistribution (extracellular-space agents, target/specific-agents, and blood-pool agents). The aim of this review is to illustrate the commercially available MRI contrast agents, their effect on imaging, and adverse reaction on the body, with the goal to lead to their proper selection in different clinical contexts. When we have to choose between the different GBCAs, we have to consider several factors: (1) safety and clinical impact; (2) biodistribution and diagnostic application; (3) higher relaxivity and better lesion detection; (4) higher stability and lower tissue deposit; (5) gadolinium dose/concentration and lower volume injection; (6) pulse sequences and protocol optimization; (7) higher contrast-to-noise ratio at 3.0 T than at 1.5 T. Knowing the patient\'s clinical information, the relevant GBCAs properties and their effect on body MRI sequences are the key features to perform efficient and high-quality MRI examination.
摘要：
钆造影剂（GBCA）有助于改善磁共振成像（MRI）在疾病诊断和治疗中的作用。目前有九种不同的市售钆造影剂（GBCA）可用于人体MRI病例，并且根据其结构（环状或线性）或生物分布（细胞外空间剂，目标/特定代理，和血池代理）。这篇综述的目的是说明市售的MRI造影剂，它们对成像的影响，以及对身体的不良反应，目的是在不同的临床环境中正确选择它们。当我们必须在不同的GBCA之间进行选择时，我们必须考虑几个因素：（1）安全性和临床影响；（2）生物分布和诊断应用；（3）更高的弛豫率和更好的病变检测；（4）更高的稳定性和更低的组织沉积；（5）钆剂量/浓度和更低的体积注射；（6）脉冲序列和方案优化；（7）在3.0T时比1.5T时更高的对比噪声比。相关的GBCA特性及其对人体MRI序列的影响是进行高效和高质量MRI检查的关键特征。
