菌核病属的成员是臭名昭著的植物病原体,具有多种寄主范围,包括许多重要作物。在该属中已鉴定出大量的分枝杆菌病毒;据报道,其中一些病毒对其真菌宿主的适应性具有低毒作用。从1990年首次针对真菌疾病实施的生物防治角度来看,这些真菌病毒对研究人员很重要。在这次审查中,我们提供了所有感染菌核病菌分离株的低毒力分枝杆菌病毒的数据.低毒力分枝杆菌病毒的数据范围从1992年到2023年。目前,属于17个不同家族的真菌病毒,包括(+)ssRNA,(-ssRNA),dsRNA,和ssDNA病毒,已从该属报告。研究进展表明,某些宿主基因的表达发生了变化(负责细胞周期调节,DNA复制,修复途径,泛素蛋白水解,基因沉默,甲基化,发病机制相关,硬化发育,碳水化合物代谢,和草酸生物合成)在分枝杆菌感染过程中,它们被称为差异表达基因(DEGs)。一起,对菌核病菌种中真菌病毒和低毒力的研究可以加深我们对细胞过程的理解,这些细胞过程会影响毒力在这些植物病原真菌中的表现,并增加分枝杆菌病毒作为一种独特的生物防治模式的潜力。此外,收集的数据也可以用于计算机内分析,其中包括查找签名站点[例如,低病毒木瓜蛋白酶(HPP)结构域,“CCHH”图案,特定的茎环结构,P29基序,如CHV1,富A序列,富含CA的序列,如MoV1中的GCU基序,如RnMBV1中的GCU基序,如CHV1中的低病毒相关RNA元件(HARE)中的核心基序],可能负责分枝杆菌病毒中的低毒力。
Members of the genus Sclerotinia are notorious plant pathogens with a diverse host range that includes many important crops. A huge number of mycoviruses have been identified in this genus; some of these viruses are reported to have a hypovirulent effect on the fitness of their fungal hosts. These mycoviruses are important to researchers from a biocontrol perspective which was first implemented against fungal diseases in 1990. In this review, we have presented the data of all hypovirulent mycoviruses infecting Sclerotinia sclerotiorum isolates. The data of hypovirulent mycoviruses ranges from 1992 to 2023. Currently, mycoviruses belonging to 17 different families, including (+) ssRNA, (-ssRNA), dsRNA, and ssDNA viruses, have been reported from this genus. Advances in studies had shown a changed expression of certain host genes (responsible for cell cycle regulation, DNA replication, repair pathways, ubiquitin proteolysis, gene silencing, methylation, pathogenesis-related, sclerotial development, carbohydrate metabolism, and oxalic acid biosynthesis) during the course of mycoviral infection, which were termed differentially expressed genes (DEGs). Together, research on fungal viruses and hypovirulence in Sclerotinia species can deepen our understanding of the cellular processes that affect how virulence manifests in these phytopathogenic fungi and increase the potential of mycoviruses as a distinct mode of biological control. Furthermore, the gathered data can also be used for in-silico analysis, which includes finding the signature sites [e.g., hypovirus papain-like protease (HPP) domain, \"CCHH\" motif, specific stem-loop structures, p29 motif as in CHV1, A-rich sequence, CA-rich sequences as in MoV1, GCU motif as in RnMBV1, Core motifs in hypovirus-associated RNA elements (HAREs) as in CHV1] that are possibly responsible for hypovirulence in mycoviruses.