目的:探讨功能活动问卷(FAQ)与脑生物标志物(双侧海马体积[HV],双侧内嗅容积[ERV],和内嗅皮层厚度[ERT])在认知正常(CN)个体中,轻度认知障碍(MCI),或痴呆症。
方法:总共,226名参与者(137名女性;平均年龄=71.76,SD=7.93;西班牙裔美国人=137;欧洲裔美国人=89)通过全面的临床检查进行评估。神经心理电池,结构磁共振成像,并被分类为CN或诊断为MCI或痴呆。线性回归分析检查了通过大脑生物标志物的FAQ测量的功能活动之间的关联,包括HV,ERV,和ERT,控制年龄,教育,全球认知,性别,和种族。
结果:FAQ显著预测了HV,ERV,和整个样本的ERT。然而,当排除痴呆组时,这种关联对于ERV和ERT并不显著.对于非痴呆组,FAQ评分仍然是HV的重要预测因子。年龄,教育,性别,种族,蒙特利尔认知评估评分,和常见问题解答也是整个样本的HV的重要预测因子,这表明年轻的西班牙裔女性受教育年限较少,更高的全球精神状态,更好的功能,更有可能有更大的HV。
结论:FAQ评分与临床组老年人的HV相关(CN,MCI和痴呆症),但是它与内嗅皮层的联系是由痴呆症患者驱动的。人口统计变量,包括种族,另外影响了这些协会。
OBJECTIVE: To investigate the association between the functional activities questionnaire (FAQ) and brain biomarkers (bilateral hippocampal volume [HV], bilateral entorhinal volume [ERV], and entorhinal cortical thickness [ERT]) in cognitively normal (CN) individuals, mild cognitive impairment (MCI), or dementia.
METHODS: In total, 226 participants (137 females; mean age = 71.76, SD = 7.93; Hispanic Americans = 137; European Americans = 89) were assessed with a comprehensive clinical examination, a neuropsychological battery, a structural magnetic resonance imaging, and were classified as CN or diagnosed with MCI or dementia. Linear regression analyses examined the association between functional activities as measured by the FAQ on brain biomarkers, including HV, ERV, and ERT, controlling for age, education, global cognition, gender, and ethnicity.
RESULTS: The FAQ significantly predicted HV, ERV, and ERT for the entire sample. However, this association was not significant for ERV and ERT when excluding the dementia group. The FAQ score remained a significant predictor of HV for the non-dementia group. Age, education, gender, ethnicity, Montreal Cognitive Assessment score, and FAQ were also significant predictors of HV for the overall sample, suggesting that younger Hispanic females with fewer years of education, higher global mental status, and better functioning, were more likely to have larger HV.
CONCLUSIONS: FAQ scores were related to HV in older adults across clinical groups (CN, MCI, and dementia), but its association with the entorhinal cortex was driven by individuals with dementia. Demographic variables, including ethnicity, additionally influenced these associations.