Abstract：
Functional assessment in neurocognitive evaluation is often provided via informant reports. These subjective reports can vary based on the characteristics of informants and their relationships with participants, such as informant sex. However, whether informant sex intersects with participant sex to impact subjective ratings of participants\' daily functioning, and whether such effects mirror observed patterns in neuropsychological performance, has not been adequately examined with ethnoracially diverse samples. We examined differences among participant-informant sex-based dyads on subjective informant reports of participants\' daily functioning (assessed via the Functional Activities Questionnaire [FAQ]), and whether any observed differences on reported functioning corresponded to differences in objective participant performance on neuropsychological performance, among middle-aged and older Hispanic/Latino (n = 543), non-Hispanic Black (NHB; n = 1030), and non-Hispanic White (NHW; n = 5356) adults in the National Alzheimer\'s Coordinating Center cohort (n = 6929). Analysis of covariance (ANCOVA) tests revealed significant dyad differences on FAQ scores in the NHB (p<.001) and NHW subsamples (p<.05), but not in the Hispanic/Latino subsample (p>.05). For the Hispanic/Latino and NHB subsamples, ANCOVA tests revealed no significant effects of dyad on neuropsychological performance (ps>.01), whereas for the NHW subsample, ANCOVA tests revealed significant dyad differences on performance in multiple cognitive domains (ps<.01). Nevertheless, the pattern of dyad differences on neuropsychological performance did not mirror the pattern of observed differences on FAQ scores in the NHW subsample. Findings and their implications, including potential contributions of other informant characteristics on observed dyad differences on reported functioning, are discussed.
摘要：
神经认知评估中的功能评估通常通过线人报告提供。这些主观报告可以根据举报人的特征及其与参与者的关系而有所不同，比如告密者的性行为。然而,举报人的性行为是否与参与者的性行为相交以影响参与者的日常功能的主观评分，以及这种效应是否反映了神经心理学表现中观察到的模式，尚未对不同类型的样本进行充分检查。我们检查了参与者-线人基于性别的二元对参与者日常功能的主观线人报告的差异（通过功能活动问卷[FAQ]评估），以及在报告的功能上观察到的任何差异是否对应于客观参与者在神经心理学表现上的表现差异，在中年和老年西班牙裔/拉丁裔（n=543），非西班牙裔黑人（NHB；n=1030），和非西班牙裔白人(NHW;n=5356)成年人在国家阿尔茨海默病协调中心队列(n=6929)。协方差分析（ANCOVA）测试显示，在NHB（p<.001）和NHW子样本（p<.05）中，常见问题解答得分存在显着差异。但不在西班牙裔/拉丁裔子样本中（p>0.05）。对于西班牙裔/拉丁裔和NHB子样本，ANCOVA测试显示dyad对神经心理学表现没有显著影响(ps>.01)，而对于NHW子样本，ANCOVA测试显示，在多个认知领域的表现存在显著的二重差异(ps<0.01)。然而，神经心理学表现的二重差异模式并不反映NHW子样本中观察到的FAQ评分差异模式.调查结果及其含义，包括其他线人特征对观察到的二元差异对报告功能的潜在贡献，正在讨论。
