■横纹肌溶解症,作为肌病的急性期,导致肾脏损伤。众所周知,这种病理是由肌肉分解产物的积累引起的,并且与氧化应激有关。因此,本研究评估了水溶性C60富勒烯腹膜内给药(剂量1mg/kg)的效果,作为强大的抗氧化剂,关于不同严重程度的比目鱼肌机械创伤引起的横纹肌溶解引起的大鼠肾脏损害的发展(挤压综合征在2.5、3.5和4.5kg/cm2的压力下持续1分钟)。
■使用张力计,生化和组织病理学分析,比目鱼肌收缩的生物力学参数(收缩力和综合肌力),大鼠血液生化指标(肌酐浓度,肌酸磷酸激酶,尿素和过氧化氢,过氧化氢酶和超氧化物歧化酶活性),肾小球滤过率和钠排泄值,研究了损伤开始后第1、3、6和9天大鼠肌肉和肾脏损伤的病理组织学和形态特征。
■在实验过程中发现生物力学和生化参数的积极变化约为27-30±2%,以及用水溶性C60富勒烯治疗的大鼠的肌肉和肾脏损伤的病理组织学和形态特征减少。
■这些发现表明水溶性C60富勒烯在治疗由横纹肌溶解和相关的氧化应激引起的肌肉系统病理状况中的潜在应用。
UNASSIGNED: Rhabdomyolysis, as an acute stage of myopathy, causes kidney damage. It is known that this pathology is caused by the accumulation of muscle breakdown products and is associated with oxidative stress. Therefore, the present study evaluated the effect of intraperitoneal administration (dose 1 mg/kg) of water-soluble C60
fullerenes, as powerful antioxidants, on the development of rat kidney damage due to rhabdomyolysis caused by mechanical trauma of the muscle soleus of different severity (crush syndrome lasting 1 min under a pressure of 2.5, 3.5, and 4.5 kg/cm2, respectively).
UNASSIGNED: Using tensometry, biochemical and histopathological analyses, the biomechanical parameters of muscle soleus contraction (contraction force and integrated muscle power), biochemical indicators of rat blood (concentrations of creatinine, creatine phosphokinase, urea and hydrogen peroxide, catalase and superoxide dismutase activity), glomerular filtration rate and fractional sodium excretion value, as well as pathohistological and morphometric features of muscle and kidney damages in rats on days 1, 3, 6 and 9 after the initiation of the injury were studied.
UNASSIGNED: Positive changes in biomechanical and biochemical parameters were found during the experiment by about 27-30 ± 2%, as well as a decrease in pathohistological and morphometric features of muscle and kidney damages in rats treated with water-soluble C60
fullerenes.
UNASSIGNED: These findings indicate the potential application of water-soluble C60
fullerenes in the treatment of pathological conditions of the muscular system caused by rhabdomyolysis and the associated oxidative stress.