背景:关于肿瘤细胞的存在是否会改变甲状腺细针抽吸(FNA)的肿瘤(RON)或恶性肿瘤(ROM)的风险,存在矛盾的结果:FN,或者嗜酸细胞瘤,ON.据我们所知,具有乳头状样核特征(NIFTP)的非侵袭性滤泡性甲状腺肿瘤的影响尚未被研究.我们比较了卵泡型AUS(AUS-FT)和嗜酸细胞型AUS(AUS-OT)以及FN和ON之间的RON和ROM。
方法:我们回顾性分析了所有诊断为AUS-其他或肿瘤的甲状腺FNA(2005-2015)。AUS-FT以微卵泡为主,AUS-OT以癌细胞为主。然后回顾组织学随访,RON,然后计算并比较ROM(在p<0.05时显著)。我们重复了2018年的搜索,以评估NIFTP效应。
结果:NIFTP前,859/5063例(17%)为AUS-FT,AUS-OT,FN,和ON。297例(35%)可进行组织学随访。AUS-FT的RON为83/183(45%),AUS-OT为35/76(46%),FN为15/25(60%),ON为11/13(85%)。NIFTP后,AUS-FT的RON为11/31(35%),AUS-OT为5/8(63%),FN为1/2(50%),ON为4/5(80%)。对于这两个时期,RON,AUS-FT的ROM与AUS-OT没有显着差异,与FN和ON相比,没有观察到显着差异。
结论:肿瘤细胞的优势不会改变隐含的RON,用于AUS或FN\\ON类别的ROM,即使在采用NIFTP之后。
BACKGROUND: There are conflicting results on whether the presence of oncocytes modifies the risk of neoplasm (RON) or malignancy (ROM) for thyroid fine-needle aspirates (FNAs): Atypia of undetermined significance AUS and Follicular Neoplasm, FN, or Oncocytic Neoplasm, ON. To our knowledge, the effect of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) has not yet been studied. We compared RON and ROM between follicular type AUS (AUS-FT) and oncocytic type AUS (AUS-OT) and between FN and ON.
METHODS: We retrospectively analysed all thyroid FNAs with the diagnostic category of AUS-other or Neoplasm (2005-2015). AUS-FT had predominance of microfollicles and AUS-OT had predominance of oncocytes. Histology follow-up was then reviewed and RON, ROM was then calculated and compared (significant at p < 0.05). We repeated the search for 2018 to evaluate for NIFTP effect.
RESULTS: Pre-NIFTP, 859/5063 cases (17%) were AUS-FT, AUS-OT, FN, and ON. Histology follow-up was available for 297 cases (35%). RON was 83/183 (45%) for AUS-FT, 35/76 (46%) for AUS-OT, 15/25 (60%) for FN and 11/13 (85%) for ON. Post-NIFTP, RON was 11/31 (35%) for AUS-FT, 5/8 (63%) for AUS-OT, 1/2 (50%) for FN and 4/5 (80%) for ON. For both periods, RON, ROM of AUS-FT was not significantly different than AUS-OT, and no significant differences were observed comparing FN and ON.
CONCLUSIONS: The predominance of oncocytes does not modify the implied RON, ROM for categories of AUS or FN\\ON, even after the adoption of NIFTP.