未经评估:本研究旨在阐明肝纤维化评分(纤维化-4,BARD评分,和BAAT评分)和慢性肾脏病(CKD)。
UNASSIGNED:我们收集了来自中国东北农村地区的11,503名受试者(男性5,326名,女性6,177名)的一系列数据。三个肝纤维化评分(LFS),包括纤维化-4(FIB-4),BARD得分,并采用BAAT评分。逻辑回归分析用于计算比值比和95%置信区间。亚组分析显示不同分层下LFSs与CKD的相关性。受限制的三次样条可以进一步探索LFSs和CKD之间是否存在线性关系。最后,我们使用了C统计量,净重新分类指数(NRI),和综合歧视改进(IDI)来评估每个LFS对CKD的影响。
UNASSIGNED:通过基线特征,我们观察到CKD人群中的LFS高于非CKD人群。CKD参与者的比例也随着LFS的增加而增加。在多元逻辑回归分析中,CKD的OR在FIB-4中为6.71(4.45-10.13),在BAAT评分中为1.88(1.29-2.75),通过比较每个LFS中的高水平和低水平,得出BARD得分中的1.72(1.28-2.31)。此外,在原始风险预测模型中加入LFS后,包括年龄,性别,饮酒,吸烟,糖尿病,低密度脂蛋白胆固醇,总胆固醇,甘油三酯,和平均腰围,我们发现新模型具有更高的C统计量。此外,NRI和IDI均表明LFS对模型有积极影响。
UNASSIGNED:我们的研究表明,在中国东北农村地区的中年人群中,LFS与CKD相关。
UNASSIGNED: This study aimed to clarify the relationship between liver fibrosis scores (Fibrosis-4, BARD score, and BAAT score) and chronic kidney disease (CKD).
UNASSIGNED: We collected a range of data from 11,503 subjects (5,326 men and 6,177 women) from the rural regions of Northeastern China. Three liver fibrosis scores (LFSs) including fibrosis-4 (FIB-4), BARD score, and BAAT score were adopted. A logistic regression analysis was used to calculate odds ratios and the 95% confidence interval. A subgroup analysis showed the association between LFSs and CKD under different stratifications. Restricted cubic spline could further explore whether there is a linear relationship between LFSs and CKD. Finally, we used C-statistics, Net Reclassification Index (NRI), and Integrated Discrimination Improvement (IDI) to assess the effect of each LFS on CKD.
UNASSIGNED: Through the baseline characteristics, we observed that LFSs were higher in the CKD population than in non-CKD. The proportion of participants with CKD also increased with LFSs. In a multivariate logistic regression analysis, the ORs of CKD were 6.71 (4.45-10.13) in FIB-4, 1.88 (1.29-2.75) in the BAAT score, and 1.72 (1.28-2.31) in the BARD score by comparing the high level with the low level in each LFSs. Moreover, after adding LFSs to the original risk prediction model, which consisted of age, sex, drinking, smoking, diabetes, low-density lipoprotein cholesterol, total cholesterol, triglycerides, and mean waist circumference, we found the new models have higher C-statistics. Furthermore, NRI and IDI both indicate LFSs had a positive effect on the model.
UNASSIGNED: Our study showed that LFSs are associated with CKD among middle-aged populations in rural areas of northeastern China.