%0 Journal Article
%T Predictive factors of collateral vessel development induced by oxaliplatin-based chemotherapy.
%A Mukai K
%A Nishida T
%A Matsumoto K
%A Kitanaka T
%A Hosokawa K
%A Sakamoto N
%A Okabe S
%A Fujii Y
%A Osugi N
%A Sugimoto A
%A Nakamatsu D
%A Yamamoto M
%A Fukui K
%J Int J Clin Oncol
%V 28
%N 2
%D Feb 2023
%M 36586029
%F 3.85
%R 10.1007/s10147-022-02280-z
%X <B>OBJECTIVE: </B>Oxaliplatin can lead to hepatic sinusoidal injury, called hepatic sinusoidal obstruction syndrome (SOS), resulting in portal hypertension-related complications. This could worsen the clinical course of the patients treated with oxaliplatin. Early diagnosis is challenging. We explored predictive markers of oxaliplatin-induced collateral vessels.<BR><B>METHODS: </B>Patients who received oxaliplatin-based chemotherapy were retrospectively screened. We evaluated their laboratory findings and spleen size on computed tomography immediately before oxaliplatin-based chemotherapy and after 6 months of treatment. The primary outcome was collateral vessel development, as a surrogate marker for oxaliplatin-induced SOS in patients who underwent oxaliplatin-based chemotherapy. The secondary outcome was the identification of factors that predicted the development of collateral vessels.<BR><B>RESULTS: </B>We enrolled 161 patients who received oxaliplatin-based chemotherapy. They had a median age of 69 years, and 63.3% were men. Collateral vessels developed in nine (5.6%) patients during the study period. After oxaliplatin-based chemotherapy, the spleen size increased in 104 patients (64.6%), with a ≥ 30% increase in 19.4% of the patients. Univariate analysis showed that the Fibrosis-4 (FIB-4) index (≥ 1.76; OR 9.17), aspartate aminotransferase:platelet ratio index (APRI) (≥ 0.193; OR 9.62), cumulative dose of oxaliplatin (≥ 1000 mg; OR 8.43), and increase in spleen size (≥ 30%; OR 6.01) were significant risk factors for collateral vessel development. Multivariate analysis after stepwise selection revealed that the FIB-4 index and spleen size were significant independent predictive factors.<BR><B>CONCLUSIONS: </B>A ≥ 1.76 increase in the FIB-4 index and a ≥ 30% increase in spleen size after 6 months of oxaliplatin-based chemotherapy were significant predictive markers for collateral vessel development.