介绍叶状肿瘤(PT)是一种罕见的乳腺纤维上皮肿瘤。它是一种具有间质和上皮成分的双相肿瘤,有复发的倾向。由于其广泛的疾病表现,它被分为三类,即,良性,边界线,恶性,基于几个组织学参数。本研究旨在评估与乳腺PT恶性肿瘤相关的临床病理特征。方法我们在Liaquat国立医院组织病理学部门进行了一项回顾性研究,卡拉奇,巴基斯坦。该研究共纳入146例经活检证实的PT病例。临床数据来自临床转诊表格。从肿块切除术或简单乳房切除术中获得标本。获得的标本在实验室接受,经过粗略检查,制备石蜡包埋的组织块,这些都是分段的,染色,并由高级组织病理学家研究。病理特征,如有丝分裂计数,坏死,基质异型性,基质过度生长,和异源元素,被观察到。基于这些特征,PT被分类为良性的,边界线,和恶性肿瘤。结果我们设置中PT的平均年龄为40.65±12.17岁,平均尺寸为9.40±6.49厘米。恶性PT在我们的人群中最普遍,占63例(43.2%),其次是边缘(51,34.9%)和良性(32,21.9%)。发现肿瘤亚型与患者年龄之间存在显着关联,即,诊断为恶性和交界性PT的患者年龄较大(平均42.82±12.94和42.05±11.31岁,分别)比诊断为良性PT的患者(平均年龄34.12±9.75岁)。此外,与其他两种亚型相比,恶性PT与较大的肿瘤大小(平均11.46±6.08)相关.结论我们发现患者年龄之间存在显著关联,肿瘤大小,和PT亚型。因此,除了通常的组织学参数,患者年龄和肿瘤大小是预测乳腺PT行为的重要参数,应考虑治疗.
Introduction Phyllodes tumor (PT) is an uncommon fibroepithelial neoplasm of the breast. It is a biphasic tumor with stromal and epithelial components, with a tendency to recur. Because of its wide range of disease manifestations, it has been subclassified into three categories, i.e., benign, borderline, and malignant, based on several histological parameters. This study was conducted to evaluate the clinicopathological features associated with malignancy in breast PTs. Methods We conducted a retrospective study at the Department of Histopathology at Liaquat National Hospital, Karachi, Pakistan. A total of 146 biopsy-proven cases of PTs were enrolled in the study. Clinical data were obtained from the clinical referral forms. Specimens were obtained from either lumpectomy or simple mastectomy. The specimens obtained were received at the laboratory where after gross examination, paraffin-embedded tissue blocks were prepared, which were sectioned, stained, and studied by a senior histopathologist. Pathological features, such as mitotic count, necrosis, stromal atypia, stromal overgrowth, and heterologous elements, were observed. Based on these features, the PTs were classified into benign, borderline, and malignant tumors. Results The mean age of the PTs in our setup was 40.65 ± 12.17 years with a mean size of 9.40 ± 6.49 cm. Malignant PT was found to be the most prevalent in our population, accounting for 63 (43.2%) cases, followed by borderline (51, 34.9%) and benign (32, 21.9%). A significant association was found between the tumor subtype and patient age, i.e., patients diagnosed with malignant and borderline PTs were found to be of older age (mean 42.82 ± 12.94 and 42.05 ± 11.31 years, respectively) than those diagnosed with benign PTs (mean age 34.12 ± 9.75 years). Moreover, malignant PTs were associated with larger tumor size (mean 11.46 ± 6.08) compared with the other two subtypes. Conclusion We found a significant association among patient age, tumor size, and PT subtype. Therefore, apart from the usual histological parameters, patient age and tumor size are important parameters for predicting the behavior of breast PT and should be considered for management.