关键词: breast mass fibroadenoma fibroepithelial lesion phyllodes tumor

Mesh : Humans Female Phyllodes Tumor / diagnostic imaging Breast / pathology Fibroadenoma / diagnostic imaging Breast Neoplasms / diagnosis Stromal Cells / pathology

来  源:   DOI:10.1093/jbi/wbac026

Abstract:
Fibroepithelial lesions (FEL) of the breast encompass a spectrum of masses ranging from benign to malignant. Although these lesions are on the same biologic spectrum, differences in their clinical behaviors necessitate different management approaches. While imaging features are nonspecific, small size (less than 3 cm), oval shape, circumscribed margins, growth in diameter less than 20% in six months, and homogeneous echotexture on US favor fibroadenoma (FA). Conversely, larger size (3 cm or larger), rapid growth, irregular shape, noncircumscribed margins, and heterogeneous echotexture suggest possible phyllodes tumor (PT). Histopathologically, increased stromal cellularity, stromal atypia, and mitotic activity characterize PT, while FA typically lack these features. In this review, we summarize the imaging and pathology characteristics of nonmalignant FEL, including simple, juvenile, and complex FA, and benign and borderline PT and highlight the collaborative role of radiologists and pathologists in informing diagnosis and clinical management.
摘要:
乳腺纤维上皮病变(FEL)包括从良性到恶性的肿块。尽管这些病变在相同的生物光谱上,他们临床行为的差异需要不同的管理方法。虽然成像特征是非特异性的,小尺寸(小于3厘米),椭圆形,外接边缘,直径在六个月内增长不到20%,美国有利于纤维腺瘤(FA)的均匀回声结构。相反,更大的尺寸(3厘米或更大),快速增长,不规则形状,无限制的边缘,异质回声结构提示可能的叶状肿瘤(PT)。组织病理学,增加基质细胞,基质异型性,和有丝分裂活性表征PT,而FA通常缺乏这些特征。在这次审查中,总结非恶性FEL的影像学和病理学特点,包括简单的,少年,和复杂的FA,以及良性和临界PT,并强调放射科医生和病理学家在诊断和临床管理方面的协作作用。
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