■血栓形成是用于定义产生血栓形成倾向的条件的术语。因子V莱顿(FVL)是最常见的遗传风险因素,其频率因社会和种族而异。在这项研究中,我们的目的是确定血栓形成患者中FVL突变的频率,每种血栓疾病的FVL突变频率,FVL突变在土耳其人群中的地理分布是否存在差异,与年龄和性别的相关性,与动脉和静脉血栓形成的相关性。
■这是一项观察性病例对照和回顾性研究。已计划考虑并评估具有FVL突变检查的病例,并进行了动脉和/或静脉血栓形成的临床临时诊断,并通过放射学可视化方法和实验室检查证明了血栓形成。
■本研究共纳入了67例血栓形成患者和22例无血栓形成患者。26例血栓形成病例来自黑海地区,21人来自安纳托利亚东部,12人来自安纳托利亚中部,5来自马尔马拉,3人来自安纳托利亚东南部。没有血栓形成的病例中有11例来自黑海地区,1来自安纳托利亚东部,5人来自安纳托利亚中部,2来自马尔马拉,1来自安纳托利亚东南部,2人来自爱琴海地区。其重要性是由于在东部安纳托利亚地区发现血栓形成患病率很高。
■FVL突变频率在我国相当普遍,特别是在区域分布方面存在显著差异。此外,FVL突变不是血栓形成的唯一危险因素,和其他共存的遗传和获得性危险因素是血栓形成的重要原因。
UNASSIGNED: Thrombophilia is a term used to define the conditions creating a tendency toward thrombosis. Factor V Leiden (FVL) is the most frequently observed genetic risk factor, and its frequency varies among societies and ethnicities. In this study, our aim is to identify the frequency of FVL mutation in patients with thrombosis, the frequency of FVL mutation for each thrombosis disease, whether there is any difference in the geographical distribution of FVL mutation in the Turkish population, correlation with age and gender, and correlation with arterial and venous thrombosis.
UNASSIGNED: This is an observational case-control and retrospective study. Cases with the FVL mutation examination with clinical provisional diagnosis of arterial and/or venous thrombosis delivered and with the thrombosis proven by radiological visualization methods and laboratory examinations have been planned to be considered and assessed as cases with thrombosis.
UNASSIGNED: A total of 67 patients with thrombosis and 22 patients without thrombosis have been included within the study. Twenty-six of the cases with thrombosis were from the Black Sea region, 21 were from Eastern Anatolia, 12 were from Central Anatolia, 5 were from Marmara, and 3 were from Southeastern Anatolia. Eleven of the cases without thrombosis were from the Black Sea region, 1 was from Eastern Anatolia, 5 were from Central Anatolia, 2 were from Marmara, 1 was from Southeastern Anatolia, and 2 were from the Aegean region. The significance was resulted from the identification of thrombosis prevalence rate as significantly high in the Eastern Anatolian region.
UNASSIGNED: FVL mutation frequency is quite common in our country, and there are significant differences particularly in terms of regional distribution. Furthermore, FVL mutation is solely not the risk factor for thrombosis, and other coexisting genetic and acquired risk factors are substantial causes for the development of thrombosis.