eyelids

眼睑
  • 文章类型: Journal Article
    眼睑皮炎(ED)影响美容上重要的区域,并导致患者痛苦。尽管正在进行和最近的研究努力,ED仍然是一个多学科问题,需要进一步表征。我们旨在评估ED患者的特应性眼睑皮炎(AED)频率并进行临床分析。从01.01.1980到01.02.2024,使用以下搜索策略搜索PubMed数据库:(眼睑或眶周或眼周)和(皮炎或湿疹)。包括斑贴测试的ED患者的研究。使用JBISUMARI软件进行比例荟萃分析。我们纳入了欧洲的65项研究,北美,亚洲和澳大利亚,共有21,793名接受斑贴测试的ED患者。在经过斑贴测试的ED患者中,有27.5%(95%CI0.177,0.384)的AED报告。在8453例报告有病变分布的ED患者中,有51.6%(95%CI0.408,0.623)发现孤立性ED。包括430例孤立性AED患者。我们的荟萃分析表明,经过斑贴测试的ED患者的AED频率超过了先前估计的10%。在成年患者中发现了孤立的AED,参加接触过敏诊所。未来的研究需要阐明成人孤立性AED的全球患病率和自然史。
    Eyelid dermatitis (ED) affects a cosmetically significant area and leads to patients\' distress. Despite ongoing and recent research efforts, ED remains a multidisciplinary problem that needs further characterization. We aimed to evaluate the atopic eyelid dermatitis (AED) frequency in ED patients and to perform their clinical profiling. PubMed databases were searched from 01.01.1980 till 01.02.2024 to PRISMA guidelines using a search strategy: (eyelid OR periorbital OR periocular) AND (dermatitis or eczema). Studies with patch-tested ED patients were included. Proportional meta-analysis was performed using JBI SUMARI software. We included 65 studies across Europe, North America, Asia and Australia, with a total of 21,793 patch-tested ED patients. AED was reported in 27.5% (95% CI 0.177, 0.384) of patch-tested ED patients. Isolated ED was noted in 51.6% (95% CI 0.408, 0.623) of 8453 ED patients with reported lesion distribution, including 430 patients with isolated AED. Our meta-analysis demonstrated that the AED frequency in patch-tested ED patients exceeded the previous estimate of 10%. Isolated AED was noted in adult patients, attending contact allergy clinics. Future studies are needed to elucidate the global prevalence and natural history of isolated AED in adults.
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  • 文章类型: Journal Article
    目的:这项研究描述了与人类下眼睑老化相关的外观变化,扎根于其解剖学基础。通过这些解剖表现进行下眼睑袋的量身定制方法。
    方法:从2017年1月至2023年1月,对137例患者进行了下眼睑眼睑成形术,20至60岁。这些患者根据眶周老化的外观分为3组,主要特征是下眼睑“袋”凸起的存在和位置。我们分析了每种类型的解剖结构的相应变化,其中包括一个弱化的纤维轨道支撑系统,肌肉张力降低,眼眶脂肪增加。根据患者的分类,采用量身定制的眼睑成形术技术进行治疗。这项研究中的所有患者的随访时间为1至12个月。有了病人的许可,照片和临床信息用于评估术前和术后结果。
    结果:我们的研究确定了下眼睑的3种形态。类型1在下眼睑的内侧和下方面呈现“气泡袋”。类型2具有双凸轮廓,由纤维结缔组织划分的单独的脂肪垫突出。3型表现出单个凸面,整个下眼睑的脂肪垫均匀突出。我们已经描绘了与每种形态类型相关的解剖学变化。以“重塑”和“恢复”为基础的方法,“手术治疗的目标是纤维支持组织,以改善下眼睑恢复的结果。无并发症发生。所有术后结果均达到了外科医生和患者的期望。
    结论:外科医生必须认识到纤维结缔组织的关键作用,包括弓形扩张,下斜肌筋膜,和保留韧带的口轮匝肌-并在手术过程中努力保持或加强这些结构。基于解剖学的手术方法将更有效和安全地抵抗面部老化过程。
    OBJECTIVE: This study characterizes the appearance changes associated with aging of the human lower eyelid, grounded in its anatomical basis. Tailored approaches to lower eyelid bag are performed by these anatomical manifestations.
    METHODS: From January 2017 to January 2023, lower eyelid blepharoplasty was performed on 137 patients, aged 20 to 60 years. These patients were divided into 3 groups according to the periorbital aging appearance, primarily characterized by the presence and location of the \"bag\" bulge of the lower eyelid. We analyzed the corresponding changes in anatomical structures for each type, which included a weakened fibrous orbital support system, reduced muscle tone, and increased orbital fat. Patients were treated with tailored blepharoplasty techniques according to their classification. All patients in this study ranged in follow-up from 1 to 12 months. With patients\' permit, photographs and clinical information were taken to evaluate the preoperative and postoperative outcome.
    RESULTS: Our study identified 3 morphologies of the lower eyelid. Type 1 presents a \"bubble bag\" in the medial and inferior aspect of the lower eyelid. Type 2 features a double convexity contour, with separate fat pad herniations demarcated by fibrous connective tissue. Type 3 exhibits a single convexity with a uniform herniation of fat pads across the entire lower eyelid. We have delineated the anatomical changes associated with each morphology type. With an approach grounded in \"remodeling\" and \"recovery,\" the surgical treatment targets the fibrous support tissue to improve the outcomes of lower eyelid rejuvenation. No complications occurred. All postoperative results reached both surgeon\'s and patient\'s expectations.
    CONCLUSIONS: Surgeons must recognize the pivotal role of fibrous connective tissues-including the arcuate expansion, fascia of the inferior oblique muscle, and the orbicularis retaining ligament-and endeavor to preserve or reinforce these structures during surgical procedures. An anatomically based surgical approach would more effectively and safely to resist the facial aging process.
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  • 文章类型: Journal Article
    本研究的目的是建立水平可见虹膜直径(HVID)的规范数据,垂直可见虹膜直径(VVID),和一组南印度儿童的睑裂高度(PFH)。这项研究包括来自泰米尔纳德邦不同地区六所学校的1,234名儿童,印度。HVID,VVID,PFH是由三名验光师使用简单的毫米直尺测量的。根据他们的年龄,这些孩子被分为三组:学龄前儿童(4-5岁),小学生(6-10岁),和高中生(11-15岁)。平均年龄4.49±0.50岁,8.00±1.41年,三组分别为12.87±1.42岁,分别。平均HVID为10.45mm,10.54mm,10.73毫米,分别。平均VVID为9.18毫米,9.32mm,和9.57毫米,分别。同样,平均PFH为8.15mm,8.30mm,和8.52毫米,分别。HVID有显著差异,VVID,和PFH在三个年龄组(P≤0.001),以及6-10岁年龄组的男性和女性儿童(P≤0.05),但其他组没有。组内相关系数值(0.78-0.95)在所有参数的三名验光师之间显示出良好的一致性。HVID的正常范围,VVID,目前的研究中提出的PFH可以帮助医生诊断角膜疾病,作为隐形眼镜设计的基础,并为南印度儿童提供精确的人工晶状体屈光力计算。
    The purpose of this study was to establish the normative data of horizontal visible iris diameter (HVID), vertical visible iris diameter (VVID), and palpebral fissure height (PFH) in a cohort of South Indian children. The study included 1,234 children from six schools of different regions of Tamil Nadu state, India. HVID, VVID, and PFH were measured using a simple millimeter ruler by three optometrists. Based on their age, the children were divided into three groups: preprimary school children (4-5 years), primary school children (6-10 years), and high school children (11-15 years). Mean age was 4.49 ± 0.50 years, 8.00 ± 1.41 years, and 12.87 ± 1.42 years in the three groups, respectively. Mean HVID was 10.45 mm, 10.54 mm, and 10.73 mm, respectively. Mean VVID was 9.18 mm, 9.32 mm, and 9.57 mm, respectively. Similarly, mean PFH was 8.15 mm, 8.30 mm, and 8.52 mm, respectively. There was a significant difference in HVID, VVID, and PFH among the three age groups (P ≤ 0.001), as well as among male and female children in the 6-10 years age group (P ≤ 0.05) but not in the other groups. Intraclass correlation coefficient values (0.78-0.95) show good agreement among the three optometrists for all parameters. The normal range of HVID, VVID, and PFH presented in the current study can help practitioners in the diagnosis of corneal disorders, serve as a basis for the design of contact lenses, and enable accurate intraocular lens power calculations for South Indian children.
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  • 文章类型: Case Reports
    这项研究源于需要了解皮肤鳞状细胞癌(SCC)的不同疗法,特别是在具有挑战性的临床情况下,传统的治疗选择可能不是最佳的。该研究的目的是评估甲氨蝶呤(MTX)作为新辅助疗法治疗眼周SCC的疗效和安全性。描述了间隔2周的两次单独的病灶内MTX浸润后的患者结果。评估治疗反应,实现肿瘤大小的显着减少,随后进行手术切除的残余病变。该程序耐受性良好,随访中没有局部或远处复发。病灶内MTX可能是新辅助治疗眼周SCC的有效和安全的选择。此外,我们强调了免疫治疗在SCC治疗方法中的重要性日益增加,以及需要让专家熟悉这些新疗法.
    This study arises from the need to understand the different therapies for cutaneous squamous cell carcinoma (SCC), especially in challenging clinical situations where conventional therapeutic options may not be optimal. The purpose of the study is to assess the efficacy and safety of intralesional methotrexate (MTX) as neoadjuvant therapy in the treatment of periocular SCC. The outcome of a patient after two separate intralesional MTX infiltrations 2 weeks apart is described. Therapeutic response was evaluated, achieving a significant reduction in tumor size and subsequently performing surgical excision of the residual lesion. The procedure was well tolerated, with no local or distant recurrences in the follow up. Intralesional MTX may be an effective and safe option in the neoadjuvant treatment of periocular SCC. Furthermore, we highlight the growing importance of immunotherapy in the approach to SCC and the need to familiarize specialists with these new treatments.
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  • 文章类型: Journal Article
    目的:通过2019年新型冠状病毒病(COVID-19)大流行,评估医护人员使用N95面罩(FM)后眼睑特征的变化,并使用计算机视觉算法与作为对照组的家庭办公室工作人员进行比较。
    方法:包括60名医护人员和40名具有相似人口统计学特征的对照参与者。标准化的生物特征照片是在COV∞D-19大流行之前和之后拍摄的,由ImageJ程序分析(NIH,贝塞斯达,Md.)软件。将角膜上的中央光反射与上眼睑(UE)和下眼睑(LE)之间的距离记录为边缘反射距离。(分别为MRD1,MRD2)分析了两只眼睛的UE的足前显示(PTS)和眉毛瞳孔直径(BPD)的参数。
    结果:在COVID-19大流行之前,各组之间的测量值没有显着差异。在大流行后的医护人员群体中,MRD1、PTS、与大流行前的测量相比,BPD的右眼显着降低(分别为p=0.001,p=0.002,p=0.001),左眼也降低了相同的值。(分别为p=0.048,p=0.001,p=0.001),对照组的右眼和左眼的PTS和BPD值均降低。(分别为p=0.044,p=0.001和p=0.001,p=0.001)大流行后的MRD1测量显示,大流行后对照组的右眼或左眼均无差异。(分别为p=0.071和p=0.065)。
    结论:结果显示,两组的BPD和PTS值均独立于先前的FM使用而降低。即使MRD1值保持在正常值范围内,在医护人员组中发现显著减少,这表明原因是在长时间使用FM后新出现的上眼睑(UE)皮肤松弛症.尽管很难做出真正客观的评估,但使用标准化的生物特征照片和基于计算机的测量系统都使结果可靠。
    OBJECTIVE: To evaluate the eyelid features\' changes after N95 face mask (FM) usage in healthcare workers through the new type of Coronavirus Disease 2019 (COVID-19) pandemic and make a comparison with home-office workers as a control group with a computer vision algorithm.
    METHODS: Sixty healthcare workers and forty control participants with similar demographic features included. Standardized biometric photographs which were taken before and after the COVİD-19 pandemic, analyzed by the ImageJ program (NIH, Bethesda, Md.) software. The distances between the central light reflex on the cornea and the upper (UE) and lower eyelid (LE) were recorded as the marginal reflex distances. (MRD1, MRD2 respectively) Parameters of pretarsal show (PTS) of UE and brow pupil diameter (BPD) were analyzed for both of the eyes.
    RESULTS: There were no significant differences among the groups\' measurements before the COVID-19 pandemic. In healthcare workers\' group after the pandemic, values of MRD1, PTS, BPD showed a significant decrease in their right eye (p = 0.001, p = 0.002, p = 0.001 respectively) and same values reduced in the left eyes as well when compared with pre-pandemic measurements. (p = 0.048, p = 0.001, p = 0.001 respectively) PTS and BPD values were decreased for both right and left eyes of the controls. (p = 0.044, p = 0.001 and p = 0.001, p = 0.001 respectively) MRD1 measurements after the pandemic showed no difference either in the right or left eyes of the control group after the pandemic. (p = 0.071 and p = 0.065 respectively).
    CONCLUSIONS: Results showed that both BPD and PTS values decreased independently from the previous FM usage in both of the groups. Even though MRD1 values remained within the normal values, a significant decrease was detected in the healthcare workers group which suggested the cause was newly developed upper eyelid (UE) dermatochalasis after long hours of FM usage. Although it is hard to make a truly objective evaluation both usage of standardized biometric photographs and a computer-based measurement system makes the results reliable.
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  • 文章类型: Case Reports
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  • 文章类型: Journal Article
    目的:评价先天性上睑提肌(LPS)切除后的组织病理学表现及其与手术结局的关系。请确认作者姓名是否准确且顺序正确(给定姓名,中间名/首字母,Familyname).作者4名字:[SeyedMohsen]姓氏[Rafizadeh]。作者6名:[SeyedAli]姓[Sonbolestan]。此外,请确认元数据中的详细信息是否正确。作者姓名和顺序正确。
    方法:本回顾性研究纳入先天性上睑下垂患者。所有患者均接受了全面的眼科检查,包括术前边缘反射距离1(MRD-1)和LPS功能测量。术后随访患者3个月,然后重复测量。组织学参数,包括脂肪百分比,横纹和平滑肌,和纤维组织。分析了组织病理学发现及其与测量结果的可能相关性。
    结果:纳入67例单侧先天性上睑下垂患者。45例(67.2%)为男性。患者平均年龄为16.10±11.18岁。LPS切除后,患者的MRD-1从0.82±1.26mm明显改善为3.85±1.25mm(P=0.000)。成功率为80.3%。MRD改变与组织病理学组织百分比之间没有相关性,但手术成功与切除样本的纤维组织百分比之间存在显着相关性(P=0.033)。
    结论:LPS的组织病理学可能有助于预测先天性上睑下垂患者LPS切除后的手术结果。纤维组织的百分比起着重要作用。
    OBJECTIVE: To evaluate the histopathologic findings of Levator palpebralis superioris (LPS) muscle biopsy after LPS resection for treatment of congenital ptosis and its possible relation with surgical outcomes.Please confirm if the author names are presented accurately and in the correct sequence (given name, middle name/initial, family name). Author 4 Given name: [Seyed Mohsen] Last name [Rafizadeh]. Author 6 Given name: [Seyed Ali] Last name [Sonbolestan].Also, kindly confirm the details in the metadata are correct.The author names and the sequence are correct.
    METHODS: Congenital ptosis patients were enrolled in this retrospective study. All of them underwent full ophthalmologic examination included of Margin-reflex distance 1 (MRD-1) and LPS function measurement preoperatively. The patients were followed for 3 months for the postoperative period and after that the measurements were repeated. Histologic parameters including percentages of fat, striated and smooth muscle, and fibrous tissue. The histopathologic findings and their possible correlation with the measurements are analyzed.
    RESULTS: Sixty-seven patients with unilateral congenital ptosis were enrolled. 45 patients (67.2%) were males. The mean age of patients was 16.10 ± 11.18 years. The patients\' MRD-1 was improved significantly from 0.82 ± 1.26 mm to 3.85 ± 1.25 mm after LPS resection (P = 0.000). The success rate was 80.3%. There were no correlations between MRD change and histopathologic tissue percentages but significant correlation was found between success of surgery and fibrous tissue percentage of resected sample (P = 0.033).
    CONCLUSIONS: The histopathology of the LPS may be useful in prediction of surgical outcome after LPS resection in congenital ptosis patients. The percentage of fibrous tissue play an important role.
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  • 文章类型: Journal Article
    下咽-大口综合征是一种罕见的疾病,其特征是TWIST2突变和前板层发育不全。及时干预对于预防暴露性角膜病变至关重要,角膜溃疡,和永久性视力丧失。我们报道了一种新的方法,用于眼睑-巨大口炎综合征的多平面眼睑重建,包括在1个下眼睑中使用改良的反向斧头皮瓣,并在眼睑边缘处进行分裂,眼睑牵开器的凹陷与包皮前植皮术相结合,用于其他3个眼睑的前板层修复。
    Ablepharon-macrostomia syndrome is a rare disorder characterized by TWIST2 mutations and anterior lamellar dysgenesis. Timely intervention is critical to prevent exposure keratopathy, corneal ulceration, and permanent vision loss. We report a novel approach to multiplanar eyelid reconstruction in ablepharon-macrostomia syndrome involving use of a modified reverse hatchet flap in 1 lower eyelid along with division at the eyelid margin, recession of the eyelid retractors in conjunction with preputial skin grafting for anterior lamellar restoration in the other 3 eyelids.
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  • 文章类型: Editorial
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  • 文章类型: Letter
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