Abstract：
OBJECTIVE: To evaluate the histopathologic findings of Levator palpebralis superioris (LPS) muscle biopsy after LPS resection for treatment of congenital ptosis and its possible relation with surgical outcomes.Please confirm if the author names are presented accurately and in the correct sequence (given name, middle name/initial, family name). Author 4 Given name: [Seyed Mohsen] Last name [Rafizadeh]. Author 6 Given name: [Seyed Ali] Last name [Sonbolestan].Also, kindly confirm the details in the metadata are correct.The author names and the sequence are correct.
METHODS: Congenital ptosis patients were enrolled in this retrospective study. All of them underwent full ophthalmologic examination included of Margin-reflex distance 1 (MRD-1) and LPS function measurement preoperatively. The patients were followed for 3 months for the postoperative period and after that the measurements were repeated. Histologic parameters including percentages of fat, striated and smooth muscle, and fibrous tissue. The histopathologic findings and their possible correlation with the measurements are analyzed.
RESULTS: Sixty-seven patients with unilateral congenital ptosis were enrolled. 45 patients (67.2%) were males. The mean age of patients was 16.10 ± 11.18 years. The patients\' MRD-1 was improved significantly from 0.82 ± 1.26 mm to 3.85 ± 1.25 mm after LPS resection (P = 0.000). The success rate was 80.3%. There were no correlations between MRD change and histopathologic tissue percentages but significant correlation was found between success of surgery and fibrous tissue percentage of resected sample (P = 0.033).
CONCLUSIONS: The histopathology of the LPS may be useful in prediction of surgical outcome after LPS resection in congenital ptosis patients. The percentage of fibrous tissue play an important role.
METHODS: Congenital ptosis patients were enrolled in this retrospective study. All of them underwent full ophthalmologic examination included of Margin-reflex distance 1 (MRD-1) and LPS function measurement preoperatively. The patients were followed for 3 months for the postoperative period and after that the measurements were repeated. Histologic parameters including percentages of fat, striated and smooth muscle, and fibrous tissue. The histopathologic findings and their possible correlation with the measurements are analyzed.
RESULTS: Sixty-seven patients with unilateral congenital ptosis were enrolled. 45 patients (67.2%) were males. The mean age of patients was 16.10 ± 11.18 years. The patients\' MRD-1 was improved significantly from 0.82 ± 1.26 mm to 3.85 ± 1.25 mm after LPS resection (P = 0.000). The success rate was 80.3%. There were no correlations between MRD change and histopathologic tissue percentages but significant correlation was found between success of surgery and fibrous tissue percentage of resected sample (P = 0.033).
CONCLUSIONS: The histopathology of the LPS may be useful in prediction of surgical outcome after LPS resection in congenital ptosis patients. The percentage of fibrous tissue play an important role.
摘要：
目的：评价先天性上睑提肌(LPS)切除后的组织病理学表现及其与手术结局的关系。请确认作者姓名是否准确且顺序正确(给定姓名，中间名/首字母,Familyname).作者4名字：[SeyedMohsen]姓氏[Rafizadeh]。作者6名：[SeyedAli]姓[Sonbolestan]。此外，请确认元数据中的详细信息是否正确。作者姓名和顺序正确。
方法：本回顾性研究纳入先天性上睑下垂患者。所有患者均接受了全面的眼科检查，包括术前边缘反射距离1（MRD-1）和LPS功能测量。术后随访患者3个月，然后重复测量。组织学参数，包括脂肪百分比，横纹和平滑肌，和纤维组织。分析了组织病理学发现及其与测量结果的可能相关性。
结果：纳入67例单侧先天性上睑下垂患者。45例（67.2%）为男性。患者平均年龄为16.10±11.18岁。LPS切除后，患者的MRD-1从0.82±1.26mm明显改善为3.85±1.25mm（P=0.000）。成功率为80.3%。MRD改变与组织病理学组织百分比之间没有相关性，但手术成功与切除样本的纤维组织百分比之间存在显着相关性（P=0.033）。
结论：LPS的组织病理学可能有助于预测先天性上睑下垂患者LPS切除后的手术结果。纤维组织的百分比起着重要作用。
方法：本回顾性研究纳入先天性上睑下垂患者。所有患者均接受了全面的眼科检查，包括术前边缘反射距离1（MRD-1）和LPS功能测量。术后随访患者3个月，然后重复测量。组织学参数，包括脂肪百分比，横纹和平滑肌，和纤维组织。分析了组织病理学发现及其与测量结果的可能相关性。
结果：纳入67例单侧先天性上睑下垂患者。45例（67.2%）为男性。患者平均年龄为16.10±11.18岁。LPS切除后，患者的MRD-1从0.82±1.26mm明显改善为3.85±1.25mm（P=0.000）。成功率为80.3%。MRD改变与组织病理学组织百分比之间没有相关性，但手术成功与切除样本的纤维组织百分比之间存在显着相关性（P=0.033）。
结论：LPS的组织病理学可能有助于预测先天性上睑下垂患者LPS切除后的手术结果。纤维组织的百分比起着重要作用。
