舌根的原发性弥漫性大B细胞淋巴瘤(BOT)是一种极为罕见的实体,迄今为止,英语文献中只有少数病例。BOT非霍奇金淋巴瘤(NHL)的发病率随着年龄的增长而增加,最常见的是在生命的第六个十年之后,没有观察到的性别差异。我们的病人有六个月的右颈部肿胀史,一个月吞咽困难史,声音的变化,最终导致急性气道窘迫,导致了气管造口术.我们报告了一例极为罕见的弥漫性大B细胞淋巴瘤,表现为气道窘迫。患者使用利妥昔单抗-环磷酰胺-多柔比星-长春新碱-泼尼松(R-CHOP)化疗,为期五天的类固醇疗程,鞘内注射甲氨蝶呤.患者完全康复,在撰写本文时还活着。NHL更常见于像我们这样有先天性免疫缺陷和乳糜泻病史的患者,暴露于辐射,获得性免疫缺陷综合征,类风湿性关节炎,或Sjögren综合征。大多数报告的BOTNHL病例可能会导致吞咽困难,咽部异物感,或进行性呼吸困难。这个案例突出表明,尽管舌头的NHL是一个非常罕见的实体,不应忽视,应始终在各种良恶性肿瘤的鉴别诊断中,并可能导致呼吸迅速恶化。
Primary diffuse large B-cell lymphoma of the tongue base (BOT) is an extremely rare entity with only a few cases described in the English literature to date. The incidence of BOT non-Hodgkin\'s lymphoma (NHL) increases with age, most commonly after the sixth decade of life with no observed gender differences. Our patient presented with a six-month history of right neck swelling, one-month history of dysphagia, a change in voice, and ultimately acute airway distress, which led to a tracheostomy. We report an extremely rare case of a diffuse large B-cell lymphoma presenting with airway distress. The patient was treated using rituximab-cyclophosphamide-doxorubicin-vincristine-prednisone (R-CHOP) chemotherapy, a five-day steroid course, and one intrathecal methotrexate. The patient recovered completely and is alive at the time of this writing. NHLs occur more commonly in patients like ours with a prior history of congenital immunodeficiency and celiac disease, exposure to radiation, acquired immune deficiency syndrome, rheumatoid arthritis, or Sjögren\'s syndrome. Most reported cases of BOT NHLs may cause dysphagia, pharyngeal foreign body sensation, or progressive dyspnea. This case highlights that although NHL of the tongue is a very rare entity, it should not be overlooked and should always be in the differential diagnosis among various benign and malignant tumors and may cause rapid respiratory deterioration.