目的:比较8周运动训练的反应者和无反应者的特征,以确定冠状动脉疾病(CAD)患者关键心血管疾病结局的差异。
方法:对来自HIIT或MISSUK试验的数据进行二次分析。
方法:英国的六个门诊国民健康服务心脏康复(CR)中心。在CAD参加CR的人中,HIIT或MISS英国试验报告说,短期,低音量,高强度间歇训练(HIIT)比中等强度稳态(MISS)运动训练更有效地改善峰值摄氧量(Vo2peak)。
方法:382名CAD参与者(N=382)(平均年龄:58.8±9.6岁;平均体重指数:29.0±4.3kg/m2)。
方法:我们根据V²o2peak的有意义变化确定了响应者和非响应者,使用2种既定方法。关键临床,生活质量(QoL),两组间比较心肺运动试验(CPET)结果.
结果:反应者更可能年轻(P<0.05),并在CPET相关成果方面表现出更大的改善,例如,吸氧效率斜率,通气效率,和峰值功率输出(所有比较,P<.001)。响应者更有可能观察到QoL的改善(EQ-5D-5L;平均值Δ13.6与平均值Δ9.4;P=0.045),和高密度脂蛋白胆固醇(HDL-c)(平均Δ0.09mmol/L与平均Δ0.04mmol/L;P=.004),与无反应者相比。
结论:在接受CR的CAD患者中,运动训练的应答者更有可能更年轻,并且在健康相关QoL和HDL-c方面表现出更大的改善.
OBJECTIVE: To compare the characteristics of responders and nonresponders to 8 weeks of exercise training to determine differences in key cardiovascular disease outcomes in people with coronary artery disease (CAD).
METHODS: Secondary analysis of data from the HIIT or MISS UK trial.
METHODS: Six outpatient National Health Service cardiac rehabilitation (CR) centers in the UK. In people with CAD attending CR, the HIIT or MISS UK trial reported that short-term, low-volume, high-intensity interval training (HIIT) was more effective than moderate-intensity steady state (MISS) exercise training for improving peak oxygen uptake (V̇o2peak).
METHODS: 382 participants with CAD (N=382) (mean age: 58.8±9.6y; mean body mass index: 29.0±4.3 kg/m2).
METHODS: We identified responders and nonresponders based on a meaningful change in V̇o2peak, using 2 established methods. Key clinical, quality of life (QoL), and cardiopulmonary exercise test (CPET)-derived outcomes were compared between groups.
RESULTS: Responders were more likely to be younger (P<.05), and demonstrate greater improvement in CPET-related outcomes, for example, oxygen uptake efficiency slope, ventilatory efficiency, and peak power output (all comparisons, P<.001). Responders were more likely to observe improvements in QoL (EQ-5D-5L; mean Δ 13.6 vs mean Δ 9.4; P=.045), and high-density lipoprotein cholesterol (HDL-c) (mean Δ 0.09 mmol/L vs mean Δ 0.04 mmol/L; P=.004), compared to nonresponders.
CONCLUSIONS: In people with CAD attending CR, responders to exercise training were more likely to be younger and demonstrate greater improvements in health-related QoL and HDL-c.