■ASD中的多感觉整合(MSI)缺陷已被反复报道,并被认为是由远程连通性改变引起的。在这里,我们使用生态有效的情感表达视频研究ASD中MSI的行为和ERP相关性。
■在本研究中,我们着手调查年轻自闭症和神经典型青少年中视听MSI的电生理相关性。我们采用了高生态有效性的动态刺激(演员制作的500毫秒剪辑),描绘了单峰(视觉和听觉)的恐惧或厌恶,和双峰(视听)条件。
■我们报告了在行为和电生理水平上的强大MSI效应,以及自闭症和神经典型参与者之间的明显差异。具体来说,神经典型对照对两种情绪均表现出稳健的行为MSI,如通过双峰反应时间(RT)的显着加速所见,由米勒的种族模型不平等(RMI)证实,恐惧比厌恶具有更大的MSI效应。患有ASD的青少年,相比之下,仅出于恐惧而显示行为MSI。在电生理水平上,与单峰条件相比,双峰条件降低了视觉P100和听觉P200的幅度,并增加了视觉N170的幅度,而与组无关。此外,对所有电极进行的基于聚类的分析显示,与对照组相比,患有ASD的青少年表现出整体延迟和空间受限的MSI效应.
■鉴于我们测量的变量反映了注意力,我们的研究结果表明,MSI可以通过恐惧和厌恶对注意力产生的不同影响来调节.我们还认为,在自闭症患者中看到的MSI缺陷可以通过(a)恐惧的注意力导向效应在后期处理阶段得到补偿,在行为层面,和(b)通过增加的注意力在电生理水平上。
UNASSIGNED: Deficits in Multisensory Integration (MSI) in ASD have been reported repeatedly and have been suggested to be caused by altered long-range connectivity. Here we investigate behavioral and ERP correlates of MSI in ASD using ecologically valid videos of emotional expressions.
UNASSIGNED: In the present study, we set out to investigate the electrophysiological correlates of audiovisual MSI in young autistic and neurotypical adolescents. We employed dynamic stimuli of high ecological validity (500 ms clips produced by actors) that depicted fear or disgust in unimodal (visual and auditory), and bimodal (audiovisual) conditions.
UNASSIGNED: We report robust MSI effects at both the behavioral and electrophysiological levels and pronounced differences between autistic and neurotypical participants. Specifically, neurotypical controls showed robust behavioral MSI for both emotions as seen through a significant speed-up of bimodal response time (RT), confirmed by Miller\'s Race Model Inequality (RMI), with greater MSI effects for fear than disgust. Adolescents with ASD, by contrast, showed behavioral MSI only for fear. At the electrophysiological level, the bimodal condition as compared to the unimodal conditions reduced the amplitudes of the visual P100 and auditory P200 and increased the amplitude of the visual N170 regardless of group. Furthermore, a cluster-based analysis across all electrodes revealed that adolescents with ASD showed an overall delayed and spatially constrained MSI effect compared to controls.
UNASSIGNED: Given that the variables we measured reflect attention, our findings suggest that MSI can be modulated by the differential effects on attention that fear and disgust produce. We also argue that the MSI deficits seen in autistic individuals can be compensated for at later processing stages by (a) the attention-orienting effects of fear, at the behavioral level, and (b) at the electrophysiological level via increased attentional effort.