■Zinner综合征是一种罕见的先天性异常,表现为单侧精囊囊肿和同侧肾发育不全。虽然大多数受影响的患者无症状,并接受保守治疗,其他人有排尿等症状,射精困难,和/或疼痛,因此可能需要治疗。这些患者通常会接受侵入性手术作为一线治疗,如经尿道射精管切除术,或抽吸和排水,减少精囊囊肿内的压力,或手术切除精囊。这里报道的是一位与Zinner综合征相关的射精疼痛和盆腔不适的患者,他成功地以非侵入性的方式用西洛多辛治疗,α1-肾上腺素受体拮抗剂。
■一名37岁的日本男性患有与Zinner综合征相关的射精疼痛和盆腔不适。用西洛多辛治疗两个月,α1-阻断剂,导致完全缓解疼痛。此后,保守管理和定期随访检查已经进行了五年,不会复发射精疼痛或其他与Zinner综合征相关的症状。
■这是首例已知的Zinner综合征患者接受西洛多辛治疗的病例报告,该患者完全缓解了射精疼痛。α1-肾上腺素受体拮抗剂抑制精囊收缩的作用,以及引起尿道和前列腺的平滑肌松弛可能有助于减少与射精相关的疼痛。我们得出的结论是,在考虑手术治疗之前,应在受影响的患者中尝试西洛多辛治疗。
UNASSIGNED: Zinner syndrome is a rare congenital anomaly featuring a unilateral seminal vesicle cyst and ipsilateral renal agenesis. While the majority of affected patients are asymptomatic and followed with conservative management, others have symptoms such as micturition, ejaculatory difficulties, and/or pain, thus may require treatment. These patients often undergo an invasive procedure as first-line treatment, such as transurethral resection of the ejaculatory duct, or aspiration and drainage, which reduces pressure within the seminal vesicle cyst, or surgical resection of the seminal vesicle. Reported here is a patient with ejaculation pain and pelvic discomfort associated with Zinner syndrome who was successfully treated in a non-invasive manner with silodosin, an α1-adrenoceptor antagonist.
UNASSIGNED: A 37-year-old Japanese male had ejaculation pain and pelvic discomfort associated with Zinner syndrome. Two months of treatment with silodosin, an α1-blocker, resulted in complete pain relief. Thereafter, conservative management with regular follow-up examinations has been conducted for five years, without recurrence of ejaculation pain or other symptoms associated with Zinner syndrome.
UNASSIGNED: This is the first known published case report of a patient with Zinner syndrome treated with silodosin who was completely relieved from ejaculation pain. The effect of α1-adrenoceptor antagonists to inhibit seminal vesicle contraction, as well as cause relaxation of smooth muscles of the urethra and prostate may contribute to reduce pain associated with ejaculation. We concluded that silodosin treatment should be attempted in affected patients before considering surgical treatment.