{Reference Type}: Case Reports {Title}: First Report of a Symptomatic Calculus of the Ampulla of the Ductus Deferens. {Author}: Wiesmayr M;Meyer D;König F;Engeler D;Schmid HP;Müllhaupt G; {Journal}: J Endourol Case Rep {Volume}: 6 {Issue}: 4 {Year}: 2020 暂无{DOI}: 10.1089/cren.2020.0024 {Abstract}: Background: Similar to other secretory organs, the male spermatic ducts may develop calculi. However, this condition is described as rare in literature and usually affects the seminal vesicles. As far as we know, no cases of calculi in the ampulla of the ductus deferens have been published so far. Patients with seminal vesicle calculi usually complain of hematospermia, painful ejaculation, perineal or testicular discomfort or pain, and often experience significant impairment of quality of life. Case Presentation: We present a case of a 39-year-old patient who presented himself in an external urologic practice with recurrent hematospermia and painful ejaculation. According to the diagnosis of a seminal vesicle calculus of 1 cm in length on the right side, the patient underwent a transurethral vesiculo- and ampulloscopy with a semirigid ureteroscope whereby the stone could be located in the ampulla of the ductus deferens and removed in toto. Conclusion: Lithiasis should be kept in mind when examining patients with hematospermia and ejaculation pain. Transurethral ampulloscopy is an efficient, safe, and minimally invasive method for stone removal from the ampulla of the ductus deferens.