■不安腿综合征(RLS)是伴有失眠的患者普遍存在的感觉运动神经系统疾病,血压波动,和交感神经功能障碍。这些症状可能会破坏脑血流动力学。动态大脑自动调节(dCA)描述了脑血管系统对血压突然波动的暂时反应,保持脑血流稳定,并作为脑血管系统能力的标志。
■本研究旨在评估RLS患者的dCA。
■在这项研究中,招募RLS患者,随后将其分为四组(轻度,中度,严重,并且非常严重)基于国际RLS评定量表(IRLS)。纳入年龄和性别匹配的健康对照。通过评估相位差(PD)对所有参与者进行dCA评估。在药物治疗(普拉克索[0.125mg/天]和加巴喷丁[300mg/天])一个月后,重新评估一部分RLS患者的dCA。
■共有120例RLS患者和30例对照完成了多导睡眠图和dCA评估。中度的PD较低,严重,和非常严重的RLS组比对照组和轻度RLS组。周期性肢体运动指数(PLMI),唤醒指数,和IRLS均与RLS患者的PD呈线性相关。此外,RLS患者治疗后PD增加。
■dCA在中度受损,严重,和非常严重的RLS患者,与IRLS呈负相关,唤醒指数,PLMI。治疗1个月后,RLS患者的dCA改善。
UNASSIGNED: Restless legs syndrome (RLS) is a prevalent sensorimotor nervous system disorder in patients accompanied with insomnia, blood pressure fluctuation, and sympathetic dysfunction. These symptoms may disrupt cerebral hemodynamics. Dynamic cerebral autoregulation (dCA) describes the temporary response of cerebrovascular system to abrupt fluctuations in blood pressure, which keep cerebral blood flow stable and serve as a marker of cerebrovascular system ability.
UNASSIGNED: This research aimed to assess dCA in RLS patients.
UNASSIGNED: In this study, RLS patients were recruited and subsequently classified into four groups (mild, moderate, severe, and very severe) based on the International RLS Rating Scale (IRLS). Healthy controls matched for age and sex were enrolled. All participants were evaluated dCA by assessing phase difference (PD). A portion of patients with RLS was reassessed for dCA after one month of medication therapy (pramipexole [0.125 mg/day] and gabapentin [300 mg/day]).
UNASSIGNED: There were altogether 120 patients with RLS and 30 controls completed the polysomnography and dCA assessment. PD was lower in the moderate, severe, and very severe RLS groups than that in the controls and mild RLS groups. Periodic limb movement index (PLMI), arousal index, and IRLS all showed a linear correlation with PD in RLS patients. Additionally, PD increased in RLS patients after therapy.
UNASSIGNED: The dCA was compromised in moderate, severe, and very severe RLS patients and was negatively correlated with the IRLS, arousal index, and PLMI. After 1 month of therapy, dCA improved in RLS patients.