PDF(Pubmed)
Abstract：
BACKGROUND: Concussion is known to cause transient autonomic and cerebrovascular dysregulation that generally recovers; however, few studies have focused on individuals with an extensive concussion history.
METHODS: The case was a 26-year-old male with a history of 10 concussions, diagnosed for bipolar type II disorder, mild attention-deficit hyperactivity disorder, and a history of migraines/headaches. The case was medicated with Valproic Acid and Escitalopram. Sensor-based baseline data were collected within six months of his injury and on days 1-5, 10, and 14 post-injury. Symptom reporting, heart rate variability (HRV), neurovascular coupling (NVC), and dynamic cerebral autoregulation (dCA) assessments were completed using numerous biomedical devices (i.e., transcranial Doppler ultrasound, 3-lead electrocardiography, finger photoplethysmography).
RESULTS: Total symptom and symptom severity scores were higher for the first-week post-injury, with physical and emotional symptoms being the most impacted. The NVC response showed lowered activation in the first three days post-injury, while autonomic (HRV) and autoregulation (dCA) were impaired across all testing visits occurring in the first 14 days following his concussion.
CONCLUSIONS: Despite symptom resolution, the case demonstrated ongoing autonomic and autoregulatory dysfunction. Larger samples examining individuals with an extensive history of concussion are warranted to understand the chronic physiological changes that occur following cumulative concussions through biosensing devices.
METHODS: The case was a 26-year-old male with a history of 10 concussions, diagnosed for bipolar type II disorder, mild attention-deficit hyperactivity disorder, and a history of migraines/headaches. The case was medicated with Valproic Acid and Escitalopram. Sensor-based baseline data were collected within six months of his injury and on days 1-5, 10, and 14 post-injury. Symptom reporting, heart rate variability (HRV), neurovascular coupling (NVC), and dynamic cerebral autoregulation (dCA) assessments were completed using numerous biomedical devices (i.e., transcranial Doppler ultrasound, 3-lead electrocardiography, finger photoplethysmography).
RESULTS: Total symptom and symptom severity scores were higher for the first-week post-injury, with physical and emotional symptoms being the most impacted. The NVC response showed lowered activation in the first three days post-injury, while autonomic (HRV) and autoregulation (dCA) were impaired across all testing visits occurring in the first 14 days following his concussion.
CONCLUSIONS: Despite symptom resolution, the case demonstrated ongoing autonomic and autoregulatory dysfunction. Larger samples examining individuals with an extensive history of concussion are warranted to understand the chronic physiological changes that occur following cumulative concussions through biosensing devices.
摘要：
背景：已知脑震荡会导致短暂的自主神经和脑血管失调，通常会恢复；但是，很少有研究关注有广泛脑震荡史的个体。
方法：该病例是一名26岁的男性，有10次脑震荡史，诊断为双相II型障碍，轻度注意力缺陷多动障碍,和偏头痛/头痛史。该病例服用了丙戊酸和艾司西酞普兰。基于传感器的基线数据在他受伤后六个月内以及受伤后第1-5、10和14天收集。症状报告,心率变异性（HRV），神经血管耦合（NVC），和动态大脑自动调节(dCA)评估是使用许多生物医学设备完成的(即，经颅多普勒超声，三导联心电图,手指光电体积描记术)。
结果：伤后第一周总症状和症状严重程度评分较高，身体和情绪症状受到的影响最大。NVC反应显示损伤后前三天激活降低，而在脑震荡后的前14天内发生的所有测试访问中，自主神经（HRV）和自动调节（dCA）均受损。
结论：尽管症状缓解，该病例表现出持续的自主神经和自动调节功能障碍.有必要对具有广泛脑震荡史的个体进行检查的较大样本，以了解通过生物传感设备累积脑震荡后发生的慢性生理变化。
方法：该病例是一名26岁的男性，有10次脑震荡史，诊断为双相II型障碍，轻度注意力缺陷多动障碍,和偏头痛/头痛史。该病例服用了丙戊酸和艾司西酞普兰。基于传感器的基线数据在他受伤后六个月内以及受伤后第1-5、10和14天收集。症状报告,心率变异性（HRV），神经血管耦合（NVC），和动态大脑自动调节(dCA)评估是使用许多生物医学设备完成的(即，经颅多普勒超声，三导联心电图,手指光电体积描记术)。
结果：伤后第一周总症状和症状严重程度评分较高，身体和情绪症状受到的影响最大。NVC反应显示损伤后前三天激活降低，而在脑震荡后的前14天内发生的所有测试访问中，自主神经（HRV）和自动调节（dCA）均受损。
结论：尽管症状缓解，该病例表现出持续的自主神经和自动调节功能障碍.有必要对具有广泛脑震荡史的个体进行检查的较大样本，以了解通过生物传感设备累积脑震荡后发生的慢性生理变化。
