背景:口腔苔藓样病变或反应(OLL/OLR)是经典口腔扁平苔藓(OLP)的临床和组织学同时代,在文献中引起了很多争论。与OLP的特发性相反,OLL通常与已知的可识别的煽动因素相关联。在临床和组织学上对这些病变进行的表面检查通常显示出与OLP的许多相似之处。但是最近的数据表明,可区分的特征确实存在,并构成了大多数分类的基础。
目的:本文试图整理英语文献中有关OLL的可用数据,突出临床和组织学上的区别特征,并反映该疾病的恶性转化潜力和治疗方式。
方法:对包括PubMed、奥维德,科克伦,Pubget,Researchgate,和非医疗搜索引擎被用于审查。搜索词包括“口腔扁平苔藓”,“口腔苔藓样病变”,“口服药物反应”,\“苔藓样发育不良\”,和“牙科材料的不良影响”。
结果:OLL似乎被严重低估,大多数病例被归类为OLP。发现了明确的临床和组织学特征,以确定该病变的身份。与牙科修复材料的关联,毒品,和药物已经在这种情况的病因中得到了决定性的证实。正在利用特定标记来诊断病情并监测其进展。
结论:发现了实质性的差异特征,以将OILs描述为具有明确病因的独立实体,发病机制,与OLP相比,恶变率高。
BACKGROUND: Oral lichenoid lesions or reactions (OLLs/OLRs) are clinical and histological contemporaries of the classical oral lichen planus (OLP) that have generated a lot of debate in literature. In contrast to the idiopathic nature of OLP, OLLs are often associated with a known identifiable inciting factor. A superficial examination of these lesions clinically and histologically often reveals many similarities with OLP, but recent data indicate that distinguishable features do exist and form the basis of most classifications.
OBJECTIVE: This paper attempts to collate available data in English literature on OLLs, highlight distinguishing features clinically and histologically and reflect on the malignant transformation potential and treatment modalities of the condition.
METHODS: A comprehensive search of medical and dental databases including PubMed, Ovid, Cochrane, Pubget, Researchgate, and non-medical search engines were utilized for the review. The search words included \"oral lichen planus\", \"oral lichenoid lesions\", \"oral drug reactions\", \"lichenoid dysplasia\", and \"adverse effects of dental materials\".
RESULTS: OLLs seem to grossly underrated and most cases were clubbed as OLP. Definite clinical and histological features were uncovered to establish the identity of this lesion. Associations with dental restorative materials, drugs, and medications have been conclusively proven in the etiology of this condition. Specific markers are being utilized to diagnose the condition and monitor its progress.
CONCLUSIONS: Substantial differentiating features were uncovered to delineate OLLs as a separate entity with definite etiology, pathogenesis, and a high malignant transformation rate compared with OLP.