目的:本研究评估了患者报告的结果测量信息系统®(PROMIS®)-16概况领域评分(身体功能,参与社会角色和活动的能力,焦虑,抑郁症,睡眠障碍,疼痛干扰,认知功能-能力,和疲劳)与PROMIS-29评分和5项PROMIS认知功能评分相比。该研究旨在提供在临床和研究环境中使用这些措施的见解。
方法:使用来自全国代表的4130名成年人的数据进行分析,2022年9月至10月之间的基于概率的互联网面板。在六个月时随访了1256名背痛患者的子集。我们将PROMIS-16配置文件与来自PROMIS-29的相应领域得分和自定义的五项认知功能度量进行了比较。我们通过每个领域内的项目间相关性来评估(1)可靠性,以及(2)通过比较PROMIS-16配置文件与相应的较长PROMIS度量标准的有效性:(a)领域得分的标准化平均差异,(b)相关性,和(C)变化的一致性(即,变得更糟,保持不变,使用可靠的变化指数,从基线到6个月后,背痛患者的病情好转)。我们报告了一致的Kappa系数以及具有一致分类的参与者的频率和百分比。
结果:PROMIS-16领域的项目间相关性范围从认知功能的0.65到疼痛干扰的0.92。PROMIS-16和相应较长PROMIS域的分数之间的标准化平均差异最小(<0.2)。相应领域得分之间的相关性范围从睡眠障碍的0.82到疼痛干扰的0.98。变化组的一致性百分比从睡眠障碍的63%到疼痛干扰的88%不等。除了睡眠障碍,从PROMIS-16得出的变化组与从较长的PROMIS测量中估计的分数(Kappa系数≥0.41)显示出中等至实质的一致性.
结论:PROMIS-16领域得分的表现与更长的PROMIS度量相似,并且可以以相同的方式进行解释。这种相似性表明,PROMIS-16作为与健康相关的生活质量概况的简短测量,可用于研究。
患者报告结果测量信息系统®(PROMIS®)-16概况评估了八个与健康相关的生活质量领域(身体功能、参与社会角色和活动的能力,焦虑,抑郁症,睡眠障碍,疼痛干扰,认知功能-能力,和疲劳)每个域使用两个项目。我们评估了来自全国代表的样本中的PROMIS-16概况,基于概率的互联网面板。该研究支持PROMIS-16的可靠性和标准有效性,表明领域得分与PROMIS-29得分和自定义的五项认知功能得分密切相关,并且在变化上具有高度一致性。PROMIS-16有可能成为研究和临床环境中与健康相关的简短生活质量指标。
OBJECTIVE: This study evaluates the interpretability of Patient-Reported Outcomes Measurement Information System® (PROMIS®)-16 profile
domain scores (physical function, ability to participate in social roles and activities, anxiety, depression, sleep disturbance, pain interference, cognitive function - abilities, and fatigue) compared to the PROMIS-29 scores and a 5-item PROMIS cognitive function score. The study aims to provide insights into using these measures in clinical and research settings.
METHODS: Analyses were conducted using data from 4130 adults from a nationally representative, probability-based internet panel between September and October 2022. A subset of 1256 individuals with back pain was followed up at six months. We compared the PROMIS-16 profile with the corresponding
domain scores from the PROMIS-29 and a custom five-item cognitive function measure. We evaluated (1) reliability through inter-item correlations within each
domain and (2) criterion validity by comparing PROMIS-16 profile with the corresponding longer PROMIS measures: (a) standardized mean differences in domain scores, (b) correlations, and (c) concordance of change (i.e., got worse, stayed the same, got better) among those with back pain from baseline to six months later using the reliable change index. We report the Kappa coefficient of agreement and the frequency and percentage of participants with concordant classifications.
RESULTS: Inter-item correlations for the PROMIS-16 domains ranged from 0.65 in cognitive function to 0.92 in pain interference. Standardized mean differences between PROMIS-16 and the scores for the corresponding longer PROMIS domains were minimal (< 0.2). Correlations among the corresponding
domain scores ranged from 0.82 for sleep disturbance to 0.98 for pain interference. The percentage of concordance in change groups ranged from 63% for sleep disturbance to 88% for pain interference. Except for sleep disturbance, the change groups derived from the PROMIS-16 showed moderate to substantial agreement with scores estimated from the longer PROMIS measures (Kappa coefficients ≥ 0.41).
CONCLUSIONS: The PROMIS-16
domain scores perform similarly to the longer PROMIS measures and can be interpreted in the same way. This similarity indicates that PROMIS-16 can be useful for research as a brief health-related quality-of-life profile measure.
The Patient-Reported Outcomes Measurement Information System® (PROMIS®)-16 Profile assesses eight health-related quality of life domains (physical function, ability to participate in social roles and activities, anxiety, depression, sleep disturbance, pain interference, cognitive function – abilities, and fatigue) using two items per domain. We evaluated the PROMIS-16 profile in a sample drawn from a nationally representative, probability-based internet panel. The study supports the reliability and criterion validity of the PROMIS-16, showing that the domain scores closely align with and have high concordance in change with the PROMIS-29 scores and a custom five-item cognitive function score. The PROMIS-16 has the potential to be a brief health-related quality-of-life profile measure in research and clinical settings.