■血清阴性脊柱关节病(SpA)是一组以轴向炎症为特征的慢性疾病,少关节炎,和附着物炎。氧化应激可能导致广泛的风湿病,包括SpA.这项前瞻性病例对照研究旨在比较SpA患者和健康对照之间硫醇-二硫化物水平作为氧化应激的标志物。
■总共144例被诊断为未分化脊柱关节病的患者(USpA,n=97)或强直性脊柱炎(AS,n=47)与80名健康对照一起包括在内。血清天然硫醇(NT),总硫醇(TT),和二硫化物(D)水平使用全自动Erel方法测量。比率NT/TT,D/TT,并计算D/NT。在SpA组和健康对照之间比较硫醇-二硫化物水平。
■发现SpA组的NT和NT/TT比率显着降低(p<0.001)。二硫化物,D/NT,在SpA组中发现D/TT比率显著更高(p<0.001)。在SpA亚组之间的成对比较中,USpA组的NT和TT水平低于AS组(p=0.021),但USpA组的血清二硫化物水平高于AS组(p=0.004).在SpA患者中,与服用常规疾病缓解抗风湿药(DMARD)的组相比,服用抗肿瘤坏死因子(anti-TNF)组的TT测量值较低(p=0.039).
■与健康志愿者相比,SpA患者的硫醇-二硫化物平衡受到干扰,有利于二硫化物。天然和总硫醇测量与急性期反应物相关,可用于监测疾病活动。抗TNF治疗可能比常规DMARD更好地控制SpA患者的氧化变性过程。
UNASSIGNED: Seronegative spondyloarthropathies (SpA) are a group of chronic diseases characterized by axial inflammation, oligoarthritis, and enthesitis. Oxidative stress may contribute to a wide range of rheumatologic diseases, including SpA. This prospective case-control study was designed to compare thiol-
disulfide levels as a marker of oxidative stress between SpA patients and healthy controls.
UNASSIGNED: A total of 144 patients diagnosed with undifferentiated spondyloarthropathy (USpA, n = 97) or ankylosing spondylitis (AS, n = 47) were included along with 80 healthy controls. Serum native thiol (NT), total thiol (TT), and
disulfide (D) levels were measured using the fully automated Erel method. The ratios NT/TT, D/TT, and D/NT were calculated. Thiol-
disulfide levels were compared between the SpA groups and the healthy controls.
UNASSIGNED: The NT and NT/TT ratios were found to be significantly lower in the SpA group (p < 0.001). The
disulfide, D/NT, and D/TT ratios were found to be significantly higher in the SpA group (p < 0.001). In pairwise comparisons between the SpA subgroups, the NT and TT levels were lower in the USpA group than in the AS group (p = 0.021), but serum disulfide levels were higher in the USpA group than in the AS group (p = 0.004). Among the patients with SpA, the group taking antitumor necrosis factor (anti-TNF) had lower TT measurements compared to the group taking conventional disease modifying antirheumatic drugs (DMARD) (p = 0.039).
UNASSIGNED: The thiol-
disulfide balance is disturbed in favor of
disulfide in SpA patients compared to healthy volunteers. Native and total thiol measurements correlate with acute phase reactants and might be used to monitor disease activity. Anti-TNF therapy might control the oxidative degenerative process better than the conventional DMARD in SpA patients.