■感染性腹泻,一个重大的全球卫生挑战,洪水加剧了,气候变化和环境破坏的后果。这项综合研究旨在量化洪水事件与感染性腹泻发病率之间的关系,考虑到不同的人口,环境,和病原体特异性因素。
■在本系统综述和荟萃分析中,遵守PROSPERO协议(CRD42024498899),我们评估了2000年1月至2023年12月的观察性研究.该分析结合了PubMed的全球数据,Scopus,Embase,WebofScience,和ProQuest,关注洪水后腹泻的相对风险(RR)。这项研究涵盖了不同的变量,如年龄,性别,病原体类型,环境背景,和统计建模方法。
■荟萃分析,涉及42项高质量研究,显示洪水后腹泻发病率大幅增加(RR=1.40,95%CI[1.29-1.52])。值得注意的是,与病毒病因(RR=1.15)相比,细菌性和寄生虫性腹泻表现出更高的RR(分别为1.82和1.35).观察到明显的性别差异,女性的易感性(RR=1.55)高于男性(RR=1.35)。成年人(15岁以上)面临的风险比年轻人更大,强调年龄依赖性的脆弱性。
■这项广泛的分析证实了洪水事件与感染性腹泻风险增加之间的显着相关性,不同的病原体和人口群体。调查结果强调了在洪水多发地区迫切需要量身定制的公共卫生干预措施。注重加强卫生,疾病监测,和有针对性的教育来减轻这种升高的风险。我们的研究强调了将与洪水相关的健康风险纳入全球公共卫生规划和气候变化适应战略的至关重要性。
UNASSIGNED: Infectious diarrhea, a significant global health challenge, is exacerbated by flooding, a consequence of climate change and environmental disruption. This comprehensive study aims to quantify the association between flooding events and the incidence of infectious diarrhea, considering diverse demographic, environmental, and pathogen-specific factors.
UNASSIGNED: In this systematic review and meta-analysis, adhering to PROSPERO protocol (CRD42024498899), we evaluated observational studies from January 2000 to December 2023. The analysis incorporated global data from PubMed, Scopus, Embase, Web of Science, and ProQuest, focusing on the relative risk (RR) of diarrhea post-flooding. The study encompassed diverse variables like age, sex, pathogen type, environmental context, and statistical modeling approaches.
UNASSIGNED: The meta-analysis, involving 42 high-quality studies, revealed a substantial increase (RR = 1.40, 95% CI [1.29-1.52]) in the incidence of diarrhea following floods. Notably, bacterial and parasitic diarrheas demonstrated higher RRs (1.82 and 1.35, respectively) compared to viral etiologies (RR = 1.15). A significant sex disparity was observed, with women exhibiting a higher susceptibility (RR = 1.55) than men (RR = 1.35). Adults (over 15 years) faced a greater risk than younger individuals, highlighting age-dependent vulnerability.
UNASSIGNED: This extensive analysis confirms a significant correlation between flood events and increased infectious diarrhea risk, varying across pathogens and demographic groups. The findings highlight an urgent need for tailored public health interventions in flood-prone areas, focusing on enhanced sanitation, disease surveillance, and targeted education to mitigate this elevated risk. Our study underscores the critical importance of integrating flood-related health risks into global public health planning and climate change adaptation strategies.