据报道,职业接触二甲基乙酰胺(DMAc)会导致毒性肝炎。本研究包括60名氨纶工作者,以研究DMAc引起的中毒性肝炎的临床表现和细胞因子和淋巴细胞的表达。使用中药(还原型谷胱甘肽和护肝片)治疗它们。表现包括黄疸,虚弱,食欲,恶心,呕吐,腹胀,黄色尿液,和头晕得分。0-3、4-6、7-9和10-12分的患者百分比为33.3%,43.3%,21.7%,和1.7%,分别,治疗前,所有患者治疗后0~3分。超声和CT成像显示弥漫性肝内低密度,肝内钙化,肝损伤的迹象,脾肿大,治疗后有所改善。血液分析显示ALT,AST,TBIL,IL-6,IL-10,TNF-α,IFN-γ,CD3+%,药物治疗后CD4+/CD8+显著下降。相关分析显示ALT与TBIL呈线性正相关,AST和TBIL,IL-10和ATL,IL-10和AST,IL-10和TBIL,IFN-γ和IL-6,IFN-γ和TNF-α,和CD3+%和ALT。DMAc诱导的毒性肝炎中的促炎细胞因子和淋巴细胞反映了治疗后降低的主动免疫状态。IL-10可能抑制这种疾病的免疫反应,作为一种保护机制。
Occupational exposure to
dimethylacetamide (DMAc) has been reported to cause toxic hepatitis. Sixty spandex workers were included in this study to research the clinical manifestations and expression of cytokines and lymphocytes in DMAc-induced toxic hepatitis. Chinese drugs (reduced glutathione and Hugan tablets) were used to treat them. The manifestations including jaundice, asthenia, appetite, nausea, emesis, abdominal distension, yellow urine, and dizziness were scored. The percentages of patients rated as 0-3, 4-6, 7-9, and 10-12 points were 33.3%, 43.3%, 21.7%, and 1.7%, respectively, before treatment, and all patients showed 0-3 points after the treatment. The ultrasonic and CT imaging revealed diffuse intrahepatic hypodensity, intrahepatic calcification, signs of liver injury, and splenomegaly, which improved after therapy. Blood analysis showed that ALT, AST, TBIL, IL-6, IL-10, TNF-α, IFN-γ, CD3+%, and CD4+/CD8+ statistically decreased after drug treatment. Correlation analysis demonstrated positive linear correlations between ALT and TBIL, AST and TBIL, IL-10 and ATL, IL-10 and AST, IL-10 and TBIL, IFN-γ and IL-6, IFN-γ and TNF-α, and CD3+% and ALT. Pro-inflammatory cytokines and lymphocytes in DMAc-induced toxic hepatitis reflected an active immune state that decreased after treatment. IL-10 may inhibit the immune response in this disease, as a protective mechanism.