■我们进行了随机,双盲,在年轻人中进行安慰剂对照交叉试验,以检查剂量依赖性(600mg对1200mg),食用Ilex瓜柳茶提取物(GLE)对情绪的急性影响,认知和运动认知表现,以及它的急性心血管效应。
■25名成年人(平均值±SD,年龄=28±7岁;9M/16F)完成了熟悉,然后进行了三次随机排序的实验访问,他们消耗了600mg(GLE600)或1200mg(GLE1200)GLE或安慰剂(PLA)。补充消费后,参与者完成了情绪状态调查,对感知到的抖动的评估,能源,和重点,以及神经认知和运动认知测试。血压(BP),心率,在补充前后测定QT间期长度。
■GLE600显着改善了总情绪障碍(平均值±SE差异=-6.9±2.6au,p=0.034),疲劳惯性(-2.84±0.89au,p=0.008),感知能量(+13.00±4.49au;p=0.02),电机转速(+4.52±1.42au,p=0.008),和精神运动速度(+7.20±2.16au,p=0.005)相对于PLA。GLE1200还提高了精神运动速度(+5.08±2.16ms,p=0.045),并且通过反应时间的减少(-0.106±0.04ms,p=0.026)在神经认知跳跃测试中。GLE对抖动的影响是剂量和性别依赖性的。仅在女性中,随着GLE剂量的增加,抖动增加(p<0.001)。GLE600和GLE1200均同样使收缩压和舒张压升高4-5mmHg(p≤0.022)。GLE600和GLE1200均未严重影响QTc长度(p=0.31)。
■选择给药策略时应考虑补充GLE的目标。较低剂量的GLE(例如600毫克)似乎可以优化认知和情绪相关的结果,同时限制副作用,如女性的抖动,和更高的剂量可能是必要的(例如1200mg),以促进运动-认知表现的改善。
UNASSIGNED: We conducted a randomized, double-blind, placebo-controlled crossover trial in young adults to examine the dose-dependent (600 mg versus 1200 mg), acute effects of consumption of an Ilex guayusa tea extract (GLE) on mood, cognitive and motor-cognitive performance, as well as its acute cardiovascular effects.
UNASSIGNED: Twenty-five adults (mean ± SD, age = 28 ± 7 y; 9 M/16 F) completed familiarization and then three randomly ordered experimental visits where they consumed either 600 mg (GLE600) or 1200 mg (GLE1200) GLE or placebo (PLA). Following supplement consumption, participants completed a mood state survey, assessments of perceived jitteriness, energy, and focus, and neurocognitive and motor-cognitive testing. Blood pressure (BP), heart rate, and QT interval length were determined before and after supplementation.
UNASSIGNED: GLE600 significantly improved total mood disturbance (mean ± SE difference = -6.9 ± 2.6 au, p = 0.034), fatigue-inertia (-2.84 ± 0.89 au, p = 0.008), perceived energy (+13.00 ± 4.49 au; p = 0.02), motor speed (+4.52 ± 1.42 au, p = 0.008), and psychomotor speed (+7.20 ± 2.16 au, p = 0.005) relative to PLA. GLE1200 also improved psychomotor speed (+5.08 ± 2.16 ms, p = 0.045) and uniquely increased motor-cognitive performance as reflected by a decrease in reaction time (-0.106 ± 0.04 ms, p = 0.026) during a neurocognitive hop test. The effect of GLE on jitteriness was both dose- and sex-dependent. Jitteriness increased with increasing GLE dose in women only (p < 0.001). Both GLE600 and GLE1200 similarly increased systolic and diastolic BP by 4-5 mmHg (p ≤ 0.022). Neither GLE600 nor GLE1200 acutely influenced QTc length (p = 0.31).
UNASSIGNED: The goal of GLE supplementation should be considered when selecting a dosing strategy. Lower dosages of GLE (e.g. 600 mg) appear to optimize cognitive and mood-related outcomes while limiting side-effects such as jitteriness in women, and higher dosages may be necessary (e.g. 1200 mg) to promote improvements in motor-cognitive performance.