■唾液,口腔分泌物被认为是维持口腔稳态的重要生物调节剂。糖尿病患者唾液中葡萄糖水平升高可能对微生物多样性产生影响。比较糖尿病和非糖尿病人群的唾液微生物区系将有助于口腔健康并发症的诊断和风险评估。这将提供有关口腔微生物对口腔疾病发展的贡献的更多知识。在北印度人口中,唾液微生物群与糖尿病状态之间的关联研究较少,因此,目前的观察性研究是利用宏基因组分析来分析糖尿病患者和非糖尿病患者的唾液微生物区系.
■这项单中心非随机观察性试验在北方邦进行,印度。参与者根据他们的糖尿病状态被纳入糖尿病组(n=68)或非糖尿病组(n=68)。收集唾液后,提取DNA并进行宏基因组测序。
■Phylum拟杆菌和Fusobacteria在糖尿病个体中明显丰富(p<0.0001),而变形杆菌在非糖尿病个体中显著升高(p<0.0001)。糖尿病患者和非糖尿病患者的放线菌和Firmicutes门没有统计学差异。Veillonella,普雷沃氏菌,卟啉单胞菌,Leptotrichia,乳酸菌,糖尿病患者中链球菌和链球菌的丰度更高,而非糖尿病患者中Capnocytophaga和奈瑟氏球菌的丰度更高(p<0.05)。
■Veillonella属,普雷沃氏菌,卟啉单胞菌,Leptotrichia,乳酸菌,在印度,链球菌和糖尿病患者的几率相对较高。糖尿病人群中的微生物群与龋齿发生增加相关的风险之间的关联,牙龈炎,和牙周炎在糖尿病人群中的患病率应进行调查。
UNASSIGNED: Saliva, an oral secretion is considered an essential biological modulator involved in maintaining oral homeostasis. Increased glucose levels in diabetic patients\' saliva may have an impact on diversity of microbes. Comparing the salivary microflora of diabetic and non-diabetic cohorts will help in diagnosis and risk assessment of oral health complications. This will provide greater knowledge about the contribution of oral microbes to the development of oral illnesses. The association between salivary microbiota and diabetic state is less explored in the North Indian population, hence current observational study was performed to analyze the salivary microflora of diabetic and non-diabetic individuals using metagenomic analysis.
UNASSIGNED: This single-center non-randomized observational trial was conducted in Uttar Pradesh, India. Participants were enrolled into either diabetic (n = 68) or non-diabetic groups (n = 68) based on their diabetes status. Following saliva collection, DNA was extracted and metagenomic sequencing was performed.
UNASSIGNED: Phylum Bacteroidetes and Fusobacteria were significantly abundant in diabetic individuals (p < 0.0001), while Proteobacteria was significantly higher among non-diabetic individuals (p < 0.0001). No statistical difference in phylum Actinobacteria and Firmicutes among diabetics and non-diabetics. Veillonella, Prevotella, Porphyromonas, Leptotrichia, Lactobacillus, and Streptococcus were greater in diabetics whereas the abundance of Capnocytophaga and Neisseria was more among non-diabetics (p < 0.05).
UNASSIGNED: The genera Veillonella, Prevotella, Porphyromonas, Leptotrichia, Lactobacillus, and Streptococcus were comparatively over the odds with the diabetics in India. The association between microbiota in diabetic population and risk related to increase in occurrence of caries, gingivitis, and periodontitis in diabetic population prevalence should be investigated.