生物可降解锌合金由于其合适的降解行为和良好的生物相容性而在硬组织植入装置中具有重要的应用潜力。尽管如此,纯锌及其合金在铸态下机械不稳定,强度低,这限制了它们的临床适用性。这里,我们报告了特殊的机械,腐蚀,和热挤压Zn-5RE的生物相容性(wt。%,RE=Y的稀土;或Ho;或Er)用于可生物降解骨替代物的合金。微观结构特征,力学行为,耐腐蚀性,细胞相容性,成骨分化,比较研究了Zn-5RE合金的体内成骨能力。Zn-5Y合金表现出最佳的拉伸性能,包括138兆帕的拉伸屈服强度,极限抗拉强度为302MPa,和63%的伸长率,而Zn-5Ho合金显示出260MPa的最高压缩屈服强度和104HV的维氏硬度。Zn-5Er合金具有126MPa的拉伸屈服强度,a279兆帕极限抗拉强度,52%伸长率,196MPa压缩屈服强度,和101HV维氏显微硬度。Further,Zn-5Er合金在电化学测试中每年的腐蚀速率为130µm,在浸入测试中每年的降解速率为26µm,这是最低的测试合金。在Zn-5RE合金中,植入大鼠股骨后,它还具有最佳的体外成骨分化能力和体内成骨和骨整合能力,表明在承重可生物降解的内部骨固定应用中有前途的潜力。重要声明:这项工作报告了特殊的机械,腐蚀,热挤压(HE)Zn-5wt的生物相容性。使用单钇(Y)的%-稀土(Zn-5RE)合金,钬(Ho),和铒(Er)合金化用于可生物降解的骨植入物应用。我们的发现表明,HEZn-5Er合金的σ为279兆帕,拉伸屈服强度为126MPa,伸长率为51.6%,压缩屈服强度为196MPa,显微硬度为101.2HV。Further,HEZn-5Er显示出最低的电化学腐蚀速率为130µm/y,最低的降解速率为26µm/y,体外成骨分化能力最高,体内成骨,在Zn-5RE合金中植入大鼠股骨后的骨整合能力,表明在承重可生物降解的内部骨固定应用中有前途的潜力。
Biodegradable Zn alloys have significant application potential for hard-tissue implantation devices owing to their suitable degradation behavior and favorable biocompatibility. Nonetheless, pure Zn and its alloys in the as-cast state are mechanically instable and low in strength, which restricts their clinical applicability. Here, we report the exceptional mechanical, corrosion, and biocompatibility properties of hot-extruded Zn-5RE (wt.%, RE = rare earth of Y; or Ho; or Er) alloys intended for use in biodegradable bone substitutes. The microstructural characteristics, mechanical behavior, corrosion resistance, cytocompatibility, osteogenic differentiation, and capacity of osteogenesis in vivo of the Zn-5RE alloys are comparatively investigated. The Zn-5Y alloy demonstrates the best tensile properties, encompassing a 138 MPa tensile yield strength, a 302 MPa ultimate tensile strength, and 63% elongation, while the Zn-5Ho alloy shows the highest compression yield strength of 260 MPa and Vickers hardness of 104 HV. The Zn-5Er alloy shows a 126 MPa tensile yield strength, a 279 MPa ultimate tensile strength, 52% elongation, a 196 MPa compression yield strength, and a 101 HV Vickers microhardness. Further, the Zn-5Er alloy has a 130 µm per year corrosion rate in electrochemical tests and a 26 µm per year degradation rate in immersion tests, which is the lowest among the tested alloys. It also has the best in vitro osteogenic differentiation ability and capacity for osteogenesis and osteointegration in vivo after implantation in rat femurs among the Zn-5RE alloys, indicating promising potential in load-bearing biodegradable internal bone-fixation applications. STATEMENT OF SIGNIFICANCE: This work reports the exceptional mechanical, corrosion, and biocompatibility properties of hot-extruded (HE) Zn-5 wt.%-rare earth (Zn-5RE) alloys using single yttrium (Y), holmium (Ho), and erbium (Er) alloying for biodegradable bone-implant applications. Our findings demonstrate that the HE Zn-5Er alloy showed σuts of 279 MPa, tensile yield strength of 126 MPa, elongation of 51.6%, compression yield strength of 196 MPa, and microhardness of 101.2 HV. Further, HE Zn-5Er showed the lowest electrochemical corrosion rate of 130 µm/y and lowest degradation rate of 26 µm/y, and the highest in vitro osteogenic differentiation ability, in vivo osteogenesis, and osteointegration ability after implantation in rat femurs among the Zn-5RE alloys, indicating promising potential in load-bearing biodegradable internal bone-fixation applications.