comprehensive review

  • 文章类型: Journal Article
    腿部远端三分之一的软组织缺损具有挑战性,并且使用简单的分层厚度皮肤移植或保守措施进行治疗通常很困难。在文献中很好地描述了腓骨短肌皮瓣以覆盖此类缺陷。我们研究的目的是回顾腓骨短肌皮瓣的不同应用和潜在并发症。对所有现有证据进行了全面审查,这些证据涉及使用腓骨短肌皮瓣覆盖成年人群腿部远端三分之一的缺损。在文献检索中确定了148条记录,其中15人遇到了PICOS(患者,干预,比较,结果和研究设计)标准。所有选定的研究均为回顾性研究。总的来说,对222例接受腓骨短肌皮瓣的患者进行了分析。重建的适应症是创伤后缺陷,感染的伤口,和慢性伤口。总并发症率为21%(46/222),最常见的并发症是皮肤移植物丢失。我们观察到2例皮瓣部分丢失,17例皮肤移植物丢失,2例术后血肿,2例反复感染,局部皮瓣坏死12例,3例植皮坏死,8例伤口延迟愈合。总的来说,16例患者(7%)需要翻修手术。没有描述供体部位发病率的病例。目前的审查表明,腓骨短肌皮瓣是一种多功能和可靠的选择,用于覆盖远端腿的中小型缺损,脚踝,和足部并发症发生率和供体部位发病率低。
    Soft tissue defects of the distal third of the leg are challenging and management with simple split thickness skin graft or conservative measures is often difficult. The peroneus brevis muscle flap is well described in the literature to cover such defects. The aim of our study was to review the different applications and potential complications of the peroneus brevis muscle flap. A comprehensive review of all existing evidence on the use of peroneus brevis muscle flaps for coverage of defects in the distal third of the leg in adult populations was performed. Two hundred forty-eight records were identified in the literature search, among which 15 met the PICOS (Patient, Intervention, Comparison, Outcome and Study design) criteria. All selected studies were retrospective. Overall, 222 patients who received peroneus brevis muscle flaps were analyzed. Indications for reconstruction were post-traumatic defects, infected wounds, and chronic wounds. The overall complication rate was 21% (46/222) with the most commonly reported complication being skin graft loss. We observed 2 cases of partial flap loss, 17 cases of skin graft loss, 2 cases of post-operative hematoma, 2 cases of recurrent infection, 12 cases of partial flap necrosis, 3 cases of skin graft necrosis, and 8 cases of delayed wound healing. Overall, 16 patients (7%) required revision surgery. No cases of donor site morbidity were described. The current review shows that the peroneus brevis muscle flap is a versatile and reliable option for the coverage of small to medium sized defects of the distal leg, ankle, and foot with low complication rates and donor site morbidity.
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  • 文章类型: Journal Article
    2020年世界人口数据表显示,世界人口预计将从2020年的78亿增加到2050年的99亿(增长超过25%)。由于预期的人口增长,对可以改善健康状况和提供治疗益处的肉类的需求预计也会增加。单峰骆驼也被称为阿拉伯骆驼,或单峰骆驼(骆驼),一种适应干旱气候的假反刍动物,有生理的,生物学和代谢特征使其在沙漠环境的极端条件下生存而享有传奇的声誉,这些条件被认为对其他反刍动物具有限制性。驼肉是中东干旱地区的民族食品,东北非洲,澳大利亚和中国。对于这些医疗和营养益处,骆驼肉可以是全球可持续肉类供应的一个很好的选择。大量文献已经发表了关于牛肉的技术方面和质量特性,羊肉和猪肉,但关于驼峰骆驼肉的技术方面的信息非常有限。骆驼通常在欠发达国家饲养,它们的肉类与任何其他传统肉类来源一样营养良好。它的质量也取决于品种,性别,年龄,繁殖条件和消耗的肌肉类型。与包装新技术进步有关的现有文献汇编,据我们所知,驼肉的保质期和质量尚未得到审查。因此,这篇综述试图探索营养成分,驼肉的健康益处,以及各种技术和加工干预措施,以提高其质量和消费者的接受度。这项审查将对骆驼行业有所帮助,并强调驼肉的全球适销性和产生增值产品的潜力。
    The 2020 world population data sheet indicates that world population is projected to increase from 7.8 billion in 2020 to 9.9 billion by 2050 (Increase of more than 25%). Due to the expected growth in human population, the demand for meats that could improve health status and provide therapeutic benefits is also projected to rise. The dromedary also known as the Arabian camel, or one-humped camel ( Camelus dromedarius), a pseudo ruminant adapted to arid climates, has physiological, biological and metabolic characteristics which give it a legendary reputation for surviving in the extreme conditions of desert environments considered restrictive for other ruminants. Camel meat is an ethnic food consumed across the arid regions of Middle East, North-East Africa, Australia and China. For these medicinal and nutritional benefits, camel meat can be a great option for sustainable meat worldwide supply. A considerable amount of literature has been published on technological aspects and quality properties of beef, lamb and pork but the information available on the technological aspects of the meat of the one humped camel is very limited. Camels are usually raised in less developed countries and their meat is as nutritionally good as any other traditional meat source. Its quality also depends on the breed, sex, age, breeding conditions and type of muscle consumed. A compilation of existing literature related to new technological advances in packaging, shelf-life and quality of camel meat has not been reviewed to the best of our knowledge. Therefore, this review attempts to explore the nutritional composition, health benefits of camel meat, as well as various technological and processing interventions to improve its quality and consumer acceptance. This review will be helpful for camel sector and highlight the potential for global marketability of camel meat and to generate value added products.
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  • 文章类型: Journal Article
    下肢康复外骨骼提供了一种变革性的方法来增强患有影响下肢的运动障碍的患者的康复。这篇全面的系统综述深入研究了传感器技术和集成到这些外骨骼中的控制策略的文献,评估他们的能力,以满足用户的需求和仔细检查他们的结构设计有关传感器分布以及控制算法。审查审查了各种传感模式,包括肌电图(EMG),力,位移,和其他创新的传感器类型,在这些设备中使用,以促进准确和响应的运动控制。此外,该评论探讨了各种下肢康复外骨骼设计的优势和局限性,强调改进的领域和进一步发展的潜在途径。此外,该审查调查了最新的控制算法和分析方法,已被用于结合这些传感器系统,以优化外骨骼性能,并确保安全和有效的用户交互。通过对各种传感器技术和监控系统有更深入的了解,这篇综述旨在为下肢康复外骨骼的持续发展做出贡献,最终改善行动不便患者的生活质量。
    Lower-limb rehabilitation exoskeletons offer a transformative approach to enhancing recovery in patients with movement disorders affecting the lower extremities. This comprehensive systematic review delves into the literature on sensor technologies and the control strategies integrated into these exoskeletons, evaluating their capacity to address user needs and scrutinizing their structural designs regarding sensor distribution as well as control algorithms. The review examines various sensing modalities, including electromyography (EMG), force, displacement, and other innovative sensor types, employed in these devices to facilitate accurate and responsive motion control. Furthermore, the review explores the strengths and limitations of a diverse array of lower-limb rehabilitation-exoskeleton designs, highlighting areas of improvement and potential avenues for further development. In addition, the review investigates the latest control algorithms and analysis methods that have been utilized in conjunction with these sensor systems to optimize exoskeleton performance and ensure safe and effective user interactions. By building a deeper understanding of the diverse sensor technologies and monitoring systems, this review aims to contribute to the ongoing advancement of lower-limb rehabilitation exoskeletons, ultimately improving the quality of life for patients with mobility impairments.
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  • 文章类型: Journal Article
    强直性肌营养不良(DM)包括一系列以肌强直为特征的神经肌肉疾病,肌肉无力,和浪费。最近的研究已导致将DM识别为神经系统疾病。认知障碍是一种中枢神经系统疾病,已在各种形式的DM中观察到。神经影像学研究越来越多地将DM与白质(WM)完整性的改变联系起来,并强调了认知障碍与WM结构异常之间的关系。这篇综述旨在总结对DM患者认知障碍和大脑异常的研究,并阐明这些因素之间的相关性以及导致这些异常的潜在潜在机制。
    Myotonic dystrophy (DM) encompasses a spectrum of neuromuscular diseases characterized by myotonia, muscle weakness, and wasting. Recent research has led to the recognition of DM as a neurological disorder. Cognitive impairment is a central nervous system condition that has been observed in various forms of DM. Neuroimaging studies have increasingly linked DM to alterations in white matter (WM) integrity and highlighted the relationship between cognitive impairment and abnormalities in WM structure. This review aims to summarize investigations into cognitive impairment and brain abnormalities in individuals with DM and to elucidate the correlation between these factors and the potential underlying mechanisms contributing to these abnormalities.
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  • 文章类型: Journal Article
    肺癌,一个多方面的疾病,由于其不同的亚型和阶段,需要量身定制的治疗方法。这篇综合综述探讨了肺癌研究的复杂前景,深入研究最近的突破及其对诊断的影响,治疗,和预防。基因组分析和生物标志物鉴定开创了个性化医学的时代,实现靶向治疗,最大限度地减少对健康组织的伤害,同时有效对抗癌细胞。检查肺结核和肺癌之间的关系,揭示了将这两个条件联系起来的潜在机制。早期检测方法,尤其是低剂量计算机断层扫描,显著改善了患者的预后,强调及时干预的重要性。近年来,作为早期肺癌的外科干预措施,对肺段切除术的兴趣与日俱增。免疫疗法已经成为一种变革性的方法,利用人体的免疫系统来识别和消除癌细胞。将免疫疗法与传统治疗相结合,如化疗和靶向治疗,显示出增强的功效,解决疾病的异质性并克服耐药性。精准医学,在基因组分析的指导下,使酪氨酸激酶抑制剂等靶向疗法的发展成为可能,为个别患者提供个性化的治疗。诸如耐药性和对先进疗法的可及性有限等挑战仍然存在。强调需要协作努力和创新技术,如人工智能。尽管面临挑战,正在进行的跨学科合作和技术进步为肺癌是可以治疗和预防的未来提供了希望,减轻全球患者和医疗保健系统的负担。
    Lung cancer, a multifaceted disease, demands tailored therapeutic approaches due to its diverse subtypes and stages. This comprehensive review explores the intricate landscape of lung cancer research, delving into recent breakthroughs and their implications for diagnosis, therapy, and prevention. Genomic profiling and biomarker identification have ushered in the era of personalised medicine, enabling targeted therapies that minimise harm to healthy tissues while effectively combating cancer cells. The relationship between pulmonary tuberculosis and lung cancer is examined, shedding light on potential mechanisms linking these two conditions. Early detection methods, notably low-dose computed tomography scans, have significantly improved patient outcomes, emphasising the importance of timely interventions. There has been a growing interest in segmentectomy as a surgical intervention for early-stage lung cancer in recent years. Immunotherapy has emerged as a transformative approach, harnessing the body\'s immune system to recognise and eliminate cancer cells. Combining immunotherapy with traditional treatments, such as chemotherapy and targeted therapies, has shown enhanced efficacy, addressing the disease\'s heterogeneity and overcoming drug resistance. Precision medicine, guided by genomic profiling, has enabled the development of targeted therapies like tyrosine kinase inhibitors, offering personalised treatments tailored to individual patients. Challenges such as drug resistance and limited accessibility to advanced therapies persist, emphasising the need for collaborative efforts and innovative technologies like artificial intelligence. Despite challenges, ongoing interdisciplinary collaborations and technological advancements offer hope for a future where lung cancer is treatable and preventable, reducing the burden on patients and healthcare systems worldwide.
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  • 文章类型: Journal Article
    近年来,环境流行病学和毒理学对导致神经发育障碍患病率增加的环境因素越来越感兴趣,目的是建立适当的预防策略。进行了文献综述,发现了192篇涉及内分泌干扰物和神经发育障碍的文章,专注于多氯联苯,多溴联苯醚,双酚A,和杀虫剂。本研究有助于分析其对母婴甲状腺功能的分子机制,对婴儿神经发育至关重要,其改变与各种神经发育障碍有关。结果提供了环境神经毒素与各种神经发育障碍之间存在关联的科学证据。此外,农药和内分泌干扰物可能与神经发育障碍相关的其他可能的分子机制正在讨论中。
    In recent years, environmental epidemiology and toxicology have seen a growing interest in the environmental factors that contribute to the increased prevalence of neurodevelopmental disorders, with the purpose of establishing appropriate prevention strategies. A literature review was performed, and 192 articles covering the topic of endocrine disruptors and neurodevelopmental disorders were found, focusing on polychlorinated biphenyls, polybrominated diphenyl ethers, bisphenol A, and pesticides. This study contributes to analyzing their effect on the molecular mechanism in maternal and infant thyroid function, essential for infant neurodevelopment, and whose alteration has been associated with various neurodevelopmental disorders. The results provide scientific evidence of the association that exists between the environmental neurotoxins and various neurodevelopmental disorders. In addition, other possible molecular mechanisms by which pesticides and endocrine disruptors may be associated with neurodevelopmental disorders are being discussed.
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  • 文章类型: Review
    目标:人工智能(AI)自引入牙科以来,已经成为许多领域的重要和有价值的工具。它被应用于不同的专业,不同的用途,例如,在口腔癌的诊断中,牙周病和龋齿,以及治疗计划和预测正颌手术的结果。这次全面审查的目的是报告为牙髓学领域的应用而设计的AI模型的应用和性能。
    方法:PubMed,WebofScience,和谷歌学者被搜索到使用术语收集最相关的文章,比如AI,牙髓,和牙科。这篇综述包括56篇与人工智能及其在牙髓医学中的应用相关的论文。
    结果:AI的应用主要是发现和诊断根尖周病变,评估根部骨折,工作长度的确定,预测术后疼痛,研究根管解剖和根管再治疗的决策。AI在执行这些任务时的准确性可以达到90%。
    结论:人工智能在现代牙髓学领域具有重要的应用价值,并取得了有希望的结果。更大的多中心数据集可以为AI模型提供外部有效性。
    结论:在牙科领域,人工智能模型是专门为口腔疾病的诊断而设计的,从常见的问题,如龋齿到更复杂的疾病,如牙周病和口腔癌。AI模型可以帮助诊断,治疗计划,以及牙髓的患者管理。随着现代工具,如锥形束计算机断层扫描(CBCT),AI可以是临床医生的宝贵帮助。如何引用这篇文章:AhmedZH,AlmuharibAM,AbdulkarimAA,etal.人工智能及其在牙髓医学中的应用.JContempDentPract2023;24(11):912-917。
    OBJECTIVE: Artificial intelligence (AI) since it was introduced into dentistry, has become an important and valuable tool in many fields. It was applied in different specialties with different uses, for example, in diagnosis of oral cancer, periodontal disease and dental caries, and in the treatment planning and predicting the outcome of orthognathic surgeries. The aim of this comprehensive review is to report on the application and performance of AI models designed for application in the field of endodontics.
    METHODS: PubMed, Web of Science, and Google Scholar were searched to collect the most relevant articles using terms, such as AI, endodontics, and dentistry. This review included 56 papers related to AI and its application in endodontics.
    RESULTS: The applications of AI were in detecting and diagnosing periapical lesions, assessing root fractures, working length determination, prediction for postoperative pain, studying root canal anatomy and decision-making in endodontics for retreatment. The accuracy of AI in performing these tasks can reach up to 90%.
    CONCLUSIONS: Artificial intelligence has valuable applications in the field of modern endodontics with promising results. Larger and multicenter data sets can give external validity to the AI models.
    CONCLUSIONS: In the field of dentistry, AI models are specifically crafted to contribute to the diagnosis of oral diseases, ranging from common issues such as dental caries to more complex conditions like periodontal diseases and oral cancer. AI models can help in diagnosis, treatment planning, and in patient management in endodontics. Along with the modern tools like cone-beam computed tomography (CBCT), AI can be a valuable aid to the clinician. How to cite this article: Ahmed ZH, Almuharib AM, Abdulkarim AA, et al. Artificial Intelligence and Its Application in Endodontics: A Review. J Contemp Dent Pract 2023;24(11):912-917.
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  • 文章类型: Journal Article
    腓骨短肌属于腿的外侧隔室。它起源于腓骨骨侧面的下三分之二,并且还附着在前肌间隔膜上。它的插入通常位于第五meta骨底部的结节上,在它的侧面。然而,这种肌肉的远端附着在形态上是可变的。已经确定了不同的变化,并且已经为成年人和胎儿创建了一些分类系统。基于各种参考文献,我们创建了一个新的分类系统,并比较了每种类型的频率。这篇综述的主要目的是介绍腓骨短肌腱的形态变异及其临床意义。尤其是在自体移植的情况下进行腓骨短腱断裂的手术治疗。还将介绍这种病理学的临床方面和一些医学病例。
    The fibularis brevis muscle belongs to the lateral compartment of the leg. It originates from the lower two-thirds of the lateral surface of the fibula bone and it also is attached to the anterior intermuscular septum. Its insertion is normally located on the tuberosity at the base of the fifth metatarsal bone, on its lateral side. However, distal attachment of this muscle is morphologically variable. Different variations have been identified and some classification systems have been created for both adults and foetuses. Based on various literature references, we have created a new classification system and compared the frequency of each type. The main aim of this review is to present morphological variations of the fibularis brevis tendon with their clinical significance, especially in autografting in case of surgical treatment of fibularis brevis tendon rupture. The clinical aspect of this pathology and some medical cases will also be presented.
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  • 文章类型: Journal Article
    仆人式领导作为一种可行的领导模式,能够在日益复杂的医疗保健系统中带来积极的变化,在学者和从业者中得到了越来越多的考虑。医疗保健中越来越多的仆人式领导文献需要进行综合研究工作,以提供现有研究的整体情况。这篇系统的综述旨在综合仆人式领导的概念化,理论框架,测量工具,和法理网络(前身,调解员,结果,和主持人)与先前的医疗保健研究相关。对55项相关的医疗保健特定概念和实证研究的系统综合表明,仆人式领导在培养致力于实现医疗保健卓越绩效的员工队伍方面发挥着至关重要的作用。审查发现,全球仆人领导能力量表是医疗保健行业特定研究中最常用的仆人领导能力指标。此外,社会交换理论是解释仆人式领导对特定利益变量影响的主导支撑机制。研究结果进一步表明,仆人式领导与医疗保健中一系列有价值的个人和组织成果有着积极的关系。我们的审查有助于公务员领导理论和实践的发展,通过确定特定部门的研究在医疗保健领域。最后,我们通过提供一个详细的全景为未来的医疗保健特定的仆人领导研究在潜在的主题方面,方法的严谨,在先前的研究中,较少探索变量。
    Servant leadership has received a growing consideration among scholars and practitioners as a viable leadership model capable of bringing positive changes in the increasingly complex healthcare system. The increasing servant leadership literature in healthcare requires an integrated research work that provides a holistic picture of the existing studies. This systematic review aims to synthesize servant leadership conceptualizations, theoretical frameworks, measurement tools, and nomological networks (antecedents, mediators, outcomes, and moderators) associated with prior research in healthcare. A systematic synthesis of 55 pertinent healthcare-specific conceptual and empirical studies demonstrated that servant leadership assumes a crucial role in developing a committed workforce that contributes towards the achievement of performance excellence in healthcare. The review uncovers that the Global Servant Leadership Scale is the most utilized measure of servant leadership in sector-specific studies in healthcare. Moreover, social exchange theory is the dominant underpinning mechanism explaining the influence of servant leadership on specific variables of interest. The findings further revealed that servant leadership has a positive relationship with a range of valued individual and organizational outcomes in healthcare. Our review contributes to the development of servant leadership theory and practice through ascertaining sector-specific studies in the territory of healthcare. We finally conclude by providing a detailed panorama for future healthcare-specific servant leadership research in terms of potential topics, methodological rigor, and less explored variables in prior studies.
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  • 文章类型: Journal Article
    凝胶系统在石油和天然气工业中广泛用作封堵材料。可以通过降低地层的异质性和CO2与原油的流动性比来减轻气窜。在CO2的地质储存期间可以堵塞裂缝和其他CO2泄漏路径以增加储存稳定性。通过在经典聚合物凝胶的分子链中添加CO2响应基团,CO2响应凝胶能够密封和识别地层中的CO2,同时保持传统聚合物凝胶的优异性能。CO2响应凝胶在油气生产中的应用总体上还处于试验室试验阶段。为了真正实现CO2响应凝胶在石油和天然气工业中的商业应用,必须彻底了解各种类型的CO2响应凝胶的CO2响应机制,以及凝胶的优缺点和未来发展前景的方向。本文对各类CO2响应基团和CO2响应凝胶的研究进展和响应机制进行了综述。研究CO2响应凝胶的发展,可注射性,并对封堵性能进行了全面的回顾和总结。讨论了现有CO2响应凝胶体系的不足,并提出了未来CO2响应凝胶发展的途径。
    Gel systems are widely used as plugging materials in the oil and gas industry. Gas channeling can be mitigated by reducing the heterogeneity of the formation and the mobility ratio of CO2 to crude oil. Cracks and other CO2 leaking pathways can be plugged during the geological storage of CO2 to increase the storage stability. By adding CO2-responsive groups to the classic polymer gel\'s molecular chain, CO2 responsive gel is able to seal and recognize CO2 in the formation while maintaining the superior performance of traditional polymer gel. The application of CO2 responsive gels in oil and gas production is still in the stage of laboratory testing on the whole. To actually achieve the commercial application of CO2 responsive gels in the oil and gas industry, it is imperative to thoroughly understand the CO2 responsive mechanisms of the various types of CO2 responsive gels, as well as the advantages and drawbacks of the gels and the direction of future development prospects. This work provides an overview of the research progress and response mechanisms of various types of CO2 responsive groups and CO2 responsive gels. Studies of the CO2 responsive gel development, injectivity, and plugging performance are comprehensively reviewed and summarized. The shortcomings of the existing CO2 responsive gels system are discussed and the paths for future CO2 responsive gel development are suggested.
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