PDF(Pubmed)
Abstract：
Myotonic dystrophy (DM) encompasses a spectrum of neuromuscular diseases characterized by myotonia, muscle weakness, and wasting. Recent research has led to the recognition of DM as a neurological disorder. Cognitive impairment is a central nervous system condition that has been observed in various forms of DM. Neuroimaging studies have increasingly linked DM to alterations in white matter (WM) integrity and highlighted the relationship between cognitive impairment and abnormalities in WM structure. This review aims to summarize investigations into cognitive impairment and brain abnormalities in individuals with DM and to elucidate the correlation between these factors and the potential underlying mechanisms contributing to these abnormalities.
摘要：
强直性肌营养不良（DM）包括一系列以肌强直为特征的神经肌肉疾病，肌肉无力,和浪费。最近的研究已导致将DM识别为神经系统疾病。认知障碍是一种中枢神经系统疾病，已在各种形式的DM中观察到。神经影像学研究越来越多地将DM与白质（WM）完整性的改变联系起来，并强调了认知障碍与WM结构异常之间的关系。这篇综述旨在总结对DM患者认知障碍和大脑异常的研究，并阐明这些因素之间的相关性以及导致这些异常的潜在潜在机制。
