背景:幽门螺杆菌(H.幽门螺杆菌)感染可能与结直肠息肉/腺瘤有关,但目前的证据仍有争议。
方法:我们回顾性筛查了2020年6月15日至2023年4月30日接受结肠镜检查和幽门螺杆菌检测的655名参与者的医疗记录。数字,尺寸,location,比较H.pylori阳性和阴性组大肠息肉/腺瘤的病理类型。调整年龄,性别,吸烟,饮酒,高血压,糖尿病,脂肪肝,身体质量指数,炎症和代谢指标,进行多因素logistic回归分析,以评估幽门螺杆菌感染的数量,尺寸,location,结直肠息肉/腺瘤的病理类型,其中没有使用息肉/腺瘤作为参考。
结果:总体而言,包括508名参与者,其中154和354分为幽门螺杆菌阳性和阴性组,分别。幽门螺杆菌阳性组结直肠息肉/腺瘤明显增高(74.7%vs.65.8%,P=0.048),低度腺瘤(55.7%vs.47.6%,P=0.026),晚期腺瘤(22.6%vs.13.3%,P=0.008),和大小≥6mm的结直肠息肉/腺瘤(61.7%vs.48.5%,P=0.002)和≥10mm(25.2%vs.14.6%,P=0.004)高于H.pylori阴性组。在多变量逻辑回归分析中,幽门螺杆菌感染与低度腺瘤独立相关(OR=2.677,95CI=1.283-5.587,P=0.009),晚期腺瘤(OR=3.017,95CI=1.007-9.036,P=0.049),右侧结肠息肉/腺瘤(OR=5.553,95CI=1.679-18.360,P=0.005),大肠息肉/腺瘤大小≥10mm(OR=4.436,95CI=1.478-13.310,P=0.008),但没有大肠息肉/腺瘤的数量。
结论:H.幽门螺杆菌感染与结直肠息肉/腺瘤的风险增加有关,尤其是低度腺瘤,晚期腺瘤,右侧结肠息肉/腺瘤,和大肠息肉/腺瘤。
BACKGROUND: Helicobacter pylori (H. pylori) infection may be associated with colorectal polyps/adenomas, but the current evidence remains controversial.
METHODS: We retrospectively screened the medical records of 655 participants who underwent both colonoscopy and H. pylori test from June 15, 2020 to April 30, 2023. The number, size, location, and pathological type of colorectal polyps/adenomas were compared between H. pylori positive and negative groups. Adjusting for age, gender, smoking, drinking, hypertension, diabetes, fatty liver, body mass index, and inflammatory and metabolic indicators, multivariate logistic regression analyses were performed to evaluate the association of H. pylori infection with the number, size, location, and pathological type of colorectal polyps/adenomas, where no polyp/adenoma was used as reference.
RESULTS: Overall, 508 participants were included, of whom 154 and 354 were divided into H. pylori positive and negative groups, respectively. H. pylori positive group had significantly higher colorectal polyps/adenomas (74.7 % vs. 65.8 %, P=0.048), low-grade adenomas (55.7 % vs. 47.6 %, P=0.026), advanced adenomas (22.6 % vs. 13.3 %, P=0.008), and colorectal polyps/adenomas with sizes of ≥6 mm (61.7 % vs. 48.5 %, P=0.002) and ≥10 mm (25.2 % vs. 14.6 %, P=0.004) than H. pylori negative group. In multivariate logistic regression analyses, H. pylori infection was independently associated with low-grade adenomas (OR=2.677, 95 %CI=1.283-5.587, P=0.009), advanced adenomas (OR=3.017, 95 %CI=1.007-9.036, P=0.049), right-side colon polyps/adenomas (OR=5.553, 95 %CI=1.679-18.360, P=0.005), and colorectal polyps/adenomas with sizes of ≥10 mm (OR=4.436, 95 %CI=1.478-13.310, P=0.008), but not number of colorectal polyps/adenomas.
CONCLUSIONS: H. pylori infection is associated with increased risk of colorectal polyps/adenomas, especially low-grade adenomas, advanced adenomas, right-side colon polyps/adenomas, and large colorectal polyps/adenomas.