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  • 文章类型: Case Reports
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  • 文章类型: Journal Article
    破裂的腹主动脉瘤(rAAAs)危及生命,需要紧急手术治疗。血管内主动脉破裂修复术(rEVAR)由于其微创方法具有较低的发病率和死亡率,已成为主要策略。尤其是出现血流动力学不稳定和相关合并症的患者。在rEVAR之后,术中血管造影或早期介入后计算机断层扫描血管造影必须排除需要立即再介入的早期1型或3型内漏.rEVAR后持续的2型内漏(T2ELs),与选修案件相比,由于通过剩余的主动脉瘤破裂部位持续的血管外失血,可能导致致命的情况。因此,在rEVAR后的急性术后设置中,必须早期识别与持续出血和血流动力学不稳定相关的持续性T2ELs,并立即进行治疗.rEVAR后T2EL遮挡的不同技术和概念可用,大多数也用于选择性EVAR后的相关T2EL。除了针对持续性T2EL的各种介入栓塞手术外,一些患者需要开放手术阻断T2EL供血动脉,rEVAR后动脉瘤破裂部位的腹腔减压或直接手术补片闭塞。到目前为止,在rAAAs的严峻形势下,尚未确定rEVAR期间先发制人或术中T2EL栓塞的指征.从长远来看,rEVAR后持续的T2ELs可导致动脉瘤持续扩张,并可能出现继发性近端I型内漏,再破裂的风险增加,需要定期随访和早期考虑再干预.迄今为止,只有极少数研究对rEVAR后的T2ELs进行了调查,或将结果与选择性EVAR中的T2ELs持续性的特殊方面进行了比较.这篇叙述性综述旨在介绍目前关于发病率的知识,自然史,rEVAR后T2EL管理的相关性和策略。
    Ruptured abdominal aortic aneurysms (rAAAs) are life-threatening and require emergent surgical therapy. Endovascular aortic repair for rupture (rEVAR) has become the leading strategy due to its minimal invasive approach with expected lower morbidity and mortality, especially in patients presenting with hemodynamic instability and relevant comorbidities. Following rEVAR, intraoperative angiography or early postinterventional computed tomography angiography have to exclude early type 1 or 3 endoleaks requiring immediate reintervention. Persistent type 2 endoleaks (T2ELs) after rEVAR, in contrast to elective cases, can cause possibly lethal situations due to continuing extravascular blood loss through the remaining aortic aneurysm rupture site. Therefore, early identification of relevant persistent T2ELs associated with continuous bleeding and hemodynamic instability and immediate management is mandatory in the acute postoperative setting following rEVAR. Different techniques and concepts for the occlusion of T2ELs after rEVAR are available, and most of them are also used for relevant T2ELs after elective EVAR. In addition to various interventional embolization procedures for persistent T2ELs, some patients require open surgical occlusion of T2EL-feeding arteries, abdominal compartment decompression or direct surgical patch occlusion of the aneurysm rupture site after rEVAR. So far, in the acute situation of rAAAs, indications for preemptive or intraoperative T2EL embolization during rEVAR have not been established. In the long term, persistent T2ELs after rEVAR can lead to continuous aneurysm expansion with the possible development of secondary proximal type I endoleaks and an increased risk of re-rupture requiring regular follow-up and early consideration for reintervention. To date, only very few studies have investigated T2ELs after rEVAR or compared outcomes with those from elective EVAR regarding the special aspects of persisting T2ELs. This narrative review is intended to present the current knowledge on the incidence, natural history, relevance and strategies for T2EL management after rEVAR.
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  • 文章类型: Journal Article
    使用各种技术和新设备治疗宽颈分叉脑动脉瘤(WNBAs)已显示出良好的结果。然而,当动脉瘤颈被合并到母体血管中时,血管内盘绕技术上具有挑战性.此外,尽管最近的研究报道了NeuroformAtlas支架(NAS)辅助卷绕的良好结果,广泛的纳入标准阻碍了对其治疗复杂WNBA的有效性和安全性的精确评估。因此,这项研究评估了使用单一NAS是否是治疗复杂WNBAs的安全有效方法。
    我们治疗了76例复杂的WNBAs(未破裂,n=49;破裂,n=27)使用单一NAS辅助线圈栓塞,并回顾性分析临床和血管造影结果。
    在68名患者的队列中(平均年龄,58.3±11.6岁;男性n=20,29.4%;女性,n=48,70.6%),76个支架成功输送到目标动脉瘤,技术成功率为98.6%。76个动脉瘤中有59个(77.6%)出现完全闭塞,颈部残留16例(21.1%),部分闭塞1例(1.3%)。治疗相关的发病率包括一个分支闭塞和一个实质出血。然而,出院时未出现未破裂动脉瘤的新神经系统症状.在最终随访评估(平均12.2[6-29]个月)时,27个破裂动脉瘤中的20个预后良好(格拉斯哥预后量表评分为4或5分)。除了一次蛛网膜下腔出血.治疗后血管造影显示89.1%完全闭塞,颈部残留物占7.8%,3.1%的动脉瘤不完全闭塞。大约88.2%的患者至少通过随访诊断或磁共振血管造影进行了一次评估(平均,12.5±4.3[范围,6-29个月),有5次(7.8%)轻微复发和2次(3.1%)主要复发。
    单个NAS对于治疗掺入母体血管的WNBAs是安全有效的。
    UNASSIGNED: Treating wide-neck bifurcated cerebral aneurysms (WNBAs) using various techniques and new devices has shown favorable outcomes. However, endovascular coiling can be technically challenging when the aneurysm neck is incorporated into the parent vessel. Furthermore, although recent research has reported favorable outcomes of Neuroform Atlas stent (NAS)-assisted coiling, broad inclusion criteria have hampered precise evaluations of their effectiveness and safety for treating complex WNBAs. Therefore, this study evaluated whether the use of a single NAS is a safe and effective approach for treating complex WNBAs.
    UNASSIGNED: We treated 76 complex WNBAs (unruptured, n = 49; ruptured, n = 27) using single NAS-assisted coil embolization and retrospectively analyzed the clinical and angiographic outcomes.
    UNASSIGNED: In a cohort of 68 patients (mean age, 58.3 ± 11.6 years; males n = 20, 29.4%; females, n = 48, 70.6%), 76 stents were successfully delivered to the target aneurysms, yielding a technical success rate of 98.6%. Complete occlusion was evident in 59 (77.6%) of 76 aneurysms, with neck remnants found in 16 (21.1%) and partial occlusion in 1 (1.3%). Treatment-related morbidities comprised one branch occlusion and one parenchymal hemorrhage. However, no new neurological symptoms of unruptured aneurysms were evident at discharge. The outcomes of 20 of the 27 ruptured aneurysms were favorable (Glasgow Outcome Scale scores of 4 or 5) at the final follow-up assessment (mean 12.2 [6-29] months), except for one initial subarachnoid hemorrhage. Post-treatment angiography revealed complete occlusion in 89.1%, neck remnants in 7.8%, and incomplete occlusion in 3.1% of the aneurysms. Approximately 88.2% of the patients were assessed at least once by follow-up diagnostic or magnetic resonance angiography (mean, 12.5 ± 4.3 [range, 6-29] months), with five (7.8%) minor and two (3.1%) major recurrences.
    UNASSIGNED: A single NAS is safe and effective for treating WNBAs incorporated into parent vessels.
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  • 文章类型: Journal Article
    目的:研究临床特征和治疗选择与功能结局的关系,死亡率,和死亡时间在动脉瘤性蛛网膜下腔出血(aSAH)患者的国家样本中。
    方法:数据来自2014年9月至2018年3月进行的一项前瞻性全国多中心研究。格拉斯哥结果量表扩展(GOSE)等级,1年死亡率,和生存概率在一年后评估。Logistic单变量,多变量,和Cox回归分析用于研究变量与结局的关联。
    结果:在35.4%的患者中观察到不利的二分GOSE(dGOSE;1-4级)。大脑中动脉动脉瘤和Fisher4级首选显微外科手术。治疗方式与任何结果指标无关。二分法世界神经外科学会联合会(dWFNS),年龄,在多因素回归分析中,迟发性缺血性神经功能缺损(DIND)与dGOSE和1年死亡率显著相关.瞳孔扩张与1年死亡率结局相关。Cox回归分析显示瞳孔扩张的生存概率较低(风险比(HR)3.546),差费(HR3.688),年龄较高(HR1.051),和DIND发生(HR2.214)。
    结论:在瑞典,aSAH后的患者选择显示dGOSE值相似,1年死亡率,以及接受显微外科手术或血管内技术治疗的患者之间的生存概率。可怜的dWFNS,年龄较高,DIND与不良dGOSE显著相关,死亡率,和生存概率。瞳孔扩张与死亡率和生存概率显著相关。
    OBJECTIVE: To study associations of clinical characteristics and treatment choice with functional outcome, mortality, and time to death in a national sample of aneurysmal subarachnoidal hemorrhage (aSAH) patients.
    METHODS: Data were extracted from a prospective nationwide multicenter study performed in September 2014 to March 2018. Glasgow Outcome Scale Extended (GOSE) grade, 1-year mortality, and survival probability were assessed at one year after ictus. Logistic univariate, multivariate, and Cox regression analyses were used to study the variables\' associations with the outcomes.
    RESULTS: Unfavorable dichotomized GOSE (dGOSE; grades 1-4) was observed in 35.4% of patients. Microsurgery was preferred for middle cerebral artery aneurysms and Fisher grade 4. Treatment modality was not associated with any outcome measure. Dichotomized World Federation of Neurosurgical Societies (dWFNS), age, and delayed ischemic neurological deficit (DIND) showed significant correlations with dGOSE and 1-year mortality in multivariate regression analyses. Pupil dilatation was associated with 1-year mortality outcome. Cox regression analysis showed lower survival probability for pupil dilatation (hazard ratio (HR) 3.546), poor dWFNS (HR 3.688), higher age (HR 1.051), and DIND occurrence (HR 2.214).
    CONCLUSIONS: The patient selection in Sweden after aSAH showed similar values for dGOSE, 1-year mortality, and survival probability between patients treated with microsurgery or endovascular technique. Poor dWFNS, higher age, and DIND were significantly associated with unfavorable dGOSE, mortality, and survival probability. Pupil dilatation was significantly associated with mortality and survival probability.
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  • 文章类型: Journal Article
    背景:蛛网膜囊肿是脑脊液充盈的间隙,通常是先天性的,保守治疗或有症状时开窗治疗。由于囊壁或囊肿腔内脆弱的软脑膜血管或静脉,在蛛网膜囊肿的存在下可出现慢性硬膜下血肿(cSDH)。导致出血和随后的血肿形成。脑膜中动脉(MMA)栓塞术通常用于治疗cSDH,以替代开颅手术和疏散术。
    方法:这里,作者介绍了成人MMA栓塞后蛛网膜囊肿和cSDH同时消退的第一份已知报告。一名24岁的男性出现在急诊科,头痛恶化1个月。影像学显示存在cSDH和同侧蛛网膜囊肿。仅使用线圈用MMA栓塞治疗cSDH。栓塞后4个月的随访成像显示血肿和蛛网膜囊肿同时消退。
    结论:MMA栓塞已用于治疗cSDH。如果血肿与蛛网膜囊肿有关,MMA栓塞还可以导致两种病理的同时解决。https://thejns.org/doi/10.3171/CASE24192。
    BACKGROUND: Arachnoid cysts are cerebrospinal fluid-filled spaces that are typically congenital and treated conservatively or with fenestration when symptomatic. Chronic subdural hematomas (cSDHs) can arise in the presence of arachnoid cysts due to fragile leptomeningeal vessels or veins within the cyst wall or cyst lumen, leading to bleeding and subsequent hematoma formation. Middle meningeal artery (MMA) embolization is regularly used for the treatment of cSDH as an alternative to craniotomy and evacuation.
    METHODS: Here, the authors present the first known report of the simultaneous resolution of an arachnoid cyst and cSDH following MMA embolization in an adult. A 24-year-old male presented to the emergency department with 1 month of worsening headaches. Imaging revealed the presence of a cSDH and ipsilateral arachnoid cyst. The cSDH was treated with MMA embolization using coils exclusively. Follow-up imaging 4 months after embolization demonstrated simultaneous resolution of both the hematoma and the arachnoid cyst.
    CONCLUSIONS: MMA embolization has been used for the treatment of cSDH. In cases in which the hematoma is related to an arachnoid cyst, MMA embolization can also lead to the concurrent resolution of both pathologies. https://thejns.org/doi/10.3171/CASE24192.
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  • 文章类型: Case Reports
    动脉瘤性蛛网膜下腔出血(aSAH)是一种罕见但破坏性的并发症,发病率和死亡率增加。目前尚不清楚怀孕期间和围产期发病率是否增加。然而,在妊娠晚期,脑动脉瘤破裂的发生率高于妊娠早期。全身麻醉或脊髓麻醉期间动脉瘤破裂和蛛网膜下腔出血(SAH)的风险尚不清楚。我们报告了一例在产后即刻进行低段剖腹产(LSCS)的脊髓麻醉后,左股上动脉瘤破裂,导致高度aSAH。
    Aneurysmal subarachnoid hemorrhage (aSAH) is a rare but devastating complication with increased morbidity and mortality. It is still unclear whether the incidence is increased during pregnancy and in the peripartum period. However, the incidence of cerebral aneurysmal rupture is higher during the third trimester than in the first trimester. The risk of aneurysmal rupture and subarachnoid hemorrhage (SAH) during general anesthesia or spinal anesthesia is unclear. We report a case of left supraclinoid aneurysm rupture after spinal anesthesia for Low Segment Caesarean Section (LSCS) in the immediate postpartum period causing high-grade aSAH.
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  • 文章类型: Journal Article
    背景:治疗基底尖动脉瘤(BAA)的血管内选择是异质的,证据仅限于回顾性队列和病例系列。我们试图评估与各种血管内治疗方法相关的BAA的疗效和并发症。
    方法:PubMed的系统评价,Embase,和WebofScience坚持PRISMA准则。纳入2010年1月至2024年7月期间评估BAA血管内治疗的回顾性和前瞻性研究。相关信息,包括闭塞率,动脉瘤复发,再治疗率,和并发症进行荟萃分析。
    结果:纳入了15项1,049个BAAs的研究。动脉瘤的中位直径为8.5mm(范围为4.6-19.75),中位随访时间为33.7个月(范围6.0-117.6)。在初次盘绕后,残留的动脉瘤充盈发生率为24%(95%CI=0.16-0.32),单支架辅助卷绕后25%(s-SAC;95%CI=0.04-0.46),Y型支架置入后25%(95%CI=0.12-0.37),分流支架置入后为23%(FDS;95%CI=0.11-0.35)。初次卷取的复发率很高(27%,95%CI=0.18-0.36)和s-SAC(19%,95%CI=0.13-0.26),但Y支架显著降低(9%,95%CI=0.03-0.15)和FDS(4%,95%CI=-0.04-0.11)。一次卷取的复治率为19%(95%CI=0.12-0.26),S-SAC为17%(95%CI=0.07-0.27),5%的Y支架(95%CI=-0.03-0.12),FDS为13%(95%CI=-0.01-0.27)。Meta回归显示较大的动脉瘤有较高的并发症发生率(p=0.02)。FDS和Y支架置入术中血栓栓塞事件最常见(12%)。
    结论:不同治疗组的闭塞率相似,但与原发性卷绕相比,Y型支架置入和FDS治疗后的复发率明显较低,尽管他们携带更多的血栓栓塞并发症。
    BACKGROUND: Endovascular options for the treatment of basilar apex aneurysms (BAAs) are heterogeneous, and evidence is limited to retrospective cohorts and case series. We seek to evaluate the efficacy and complications associated with various endovascular treatment methods of BAAs.
    METHODS: Systematic review of PubMed, Embase, and Web of Science adhering to the PRISMA guidelines. Retrospective and prospective studies evaluating endovascular treatment of BAAs between January 2010 and July 2024 were included. Relevant information including occlusion rates, aneurysm recurrence, retreatment rates, and complications were subjected to meta-analysis.
    RESULTS: Fifteen studies with 1,049 BAAs were included. The median aneurysm diameter was 8.5 mm (range 4.6-19.75), with a median follow-up of 33.7 months (range 6.0-117.6). Residual aneurysm filling occurred in 24% after primary coiling (95% CI=0.16-0.32), 25% after single stent-assisted coiling (s-SAC; 95% CI=0.04-0.46), 25% after Y-stenting (95% CI=0.12-0.37), and 23% after flow diverter stenting (FDS; 95% CI=0.11-0.35). Recurrence rates were high for primary coiling (27%, 95% CI=0.18-0.36) and s-SAC (19%, 95% CI=0.13-0.26), but significantly lower for Y-stenting (9%, 95% CI=0.03-0.15) and FDS (4%, 95% CI=-0.04-0.11). Retreatment rates were 19% for primary coiling (95% CI=0.12-0.26), 17% for s-SAC (95% CI=0.07-0.27), 5% for Y-stenting (95% CI=-0.03-0.12), and 13% for FDS (95% CI=-0.01-0.27). Meta-regression indicated larger aneurysms had higher complication rates (p=0.02). Thromboembolic events were most frequent with FDS and Y-stenting (12%).
    CONCLUSIONS: Occlusion rates were similar across treatments, but recurrence rates were significantly lower after Y-stenting and FDS treatments compared to primary coiling, although they carried a higher number of thromboembolic complications.
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  • 文章类型: Case Reports
    直接颈动脉海绵窦瘘(CCF)主要由头部创伤引起。一些病例还归因于血管内手术期间的医源性损伤。然而,与直接CCF相关的功能性内窥镜鼻窦手术(FESS)的报道极为罕见.
    方法:一名52岁的男性工人,患有慢性鼻窦炎并接受了由耳鼻喉科医师进行的功能性内窥镜鼻窦手术(FESS)。术中发现左侧蝶窦壁损伤,无颈内动脉出血,用粘膜和组织胶修复。出院后一个月,他开始出现耳鸣,他的左眼头痛和肿胀。脑血管造影显示左侧有直接颈动脉海绵窦瘘(CCF)。患者接受了使用可拆卸线圈和Onyx的经动脉和经静脉支架辅助线圈,缓解了他的症状.
    FESS后的海绵状颈动脉瘘是Karaman等人首次报道的极为罕见的病例。2009年。在FESS或鼻内镜手术(EES)期间,颈内动脉损伤的发生率估计在0至0.1%之间。目前,FESS后颈动脉海绵窦瘘(CCF)的发生尚无明确的解释.先前的研究表明,诸如经蝶窦手术和EES之类的程序可以在颈内动脉中诱发假性动脉瘤。如果海绵状假性动脉瘤破裂,这可能导致CCF的形成。
    结论:功能性内窥镜鼻窦手术后的直接海绵状颈动脉瘘非常罕见。因此,当遇到颈动脉海绵窦瘘患者时,应该考虑相关的程序历史。
    UNASSIGNED: Direct carotid-cavernous fistulas (CCF) are primarily caused by head trauma. Some cases have also been attributed to iatrogenic injuries during endovascular procedures. However, the reports of functional endoscopic sinus surgery (FESS) associated with direct CCFs are extremely rare.
    METHODS: A 52-year-old male worker, who suffered from chronic sinusitis and underwent functional endoscopic sinus surgery (FESS) performed by an otolaryngologist. Intra-operative finding indicated a left sphenoid sinus wall injury without internal carotid artery bleeding, which was repaired using mucosa and tissue glue. One month after discharge, he began experiencing tinnitus, headache and swelling in his left eye. Cerebral angiography revealed a direct carotid-cavernous fistula (CCF) on the left side. The patient underwent transarterial and transvenous stent-assisted coiling using detachable coils and Onyx, which alleviated his symptoms.
    UNASSIGNED: A cavernous-carotid fistula following FESS is an exceedingly rare occurrence first reported by Karaman et al. in 2009. The incidence of internal carotid artery injury during FESS or endonasal endoscopic surgery (EES) is estimated to be between 0 and 0.1 %. Currently, there is no definitive explanation for the development of a carotid-cavernous fistula (CCF) post-FESS. Previous studies suggest that procedures like transsphenoidal surgery and EES can induce pseudoaneurysms in the internal carotid artery. If the cavernous pseudoaneurysm ruptures, it could lead to the formation of a CCF.
    CONCLUSIONS: A direct cavernous-carotid fistula following functional endoscopic sinus surgery is a very rare. Consequently, when encountering patients with a carotid-cavernous fistula, relevant procedure history should be considered.
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  • 文章类型: Case Reports
    本报告描述了一名虚弱的36岁患者的情况,该患者接受了右锁骨下动脉假性动脉瘤(SAP)的血管内治疗,并伴有继发于创伤性中心静脉导管插入的动静脉瘘。从无名处到右颈总动脉展开覆膜支架,结合SAP和乳内动脉的卷绕。另外两个覆膜支架从椎动脉部署到锁骨下动脉远端以保持右上肢循环。此案例强调了在不适合开放手术的候选人中对复杂SAP进行血管内治疗的可行性。
    This report describes the case of a frail 36-year-old patient who underwent an endovascular treatment of a right subclavian artery pseudoaneurysm (SAP) associated with an arteriovenous fistula secondary to a traumatic central venous catheter insertion. The deployment of a covered stent from the innominate to the right common carotid artery combined with coiling of the SAP and the internal mammary artery was performed. Two additional covered stents were deployed from the vertebral artery to the distal subclavian artery to preserve right upper extremity circulation. This case highlights the feasibility of an endovascular treatment of a complex SAP in a candidate unsuitable for open surgery.
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  • 文章类型: Journal Article
    背景:胎儿型大脑后动脉(PCA)被定义为一种变异的解剖结构,其中后交通动脉(PCOM)大于PCA的增生或再生能力P1段。作者介绍了一个新颖的病例,该病例具有重复的右PCA,与胎儿型和常规PCA并行,并提供PCA大脑区域的相邻成分。
    方法:一名59岁女性患者接受改良的Fisher量表评分4蛛网膜下腔出血。右不规则PCOM动脉瘤,测量9.5mm×4.5mm×4.5mm,从提供PCA一部分的变异分支的底部出现,而不是传统的PCCOM,并在数字减影血管造影中发现。血管内线圈栓塞后,病人出院回家。
    结论:胎儿型变异对血栓栓塞事件有影响。如果栓塞阻塞了胎儿型PCA患者的前循环,它可能导致PCA区域的梗塞。脑动脉解剖意识,包括非典型的抵押品供应,告知治疗团队的容忍度,哪些地点必须保留,哪些地点可以安全牺牲。https://thejns.org/doi/10.3171/CASE23735.
    BACKGROUND: The fetal-type posterior cerebral artery (PCA) is defined as a variant anatomy in which the posterior communicating artery (PCOM) is larger than the hypoplastic or aplastic P1 segment of the PCA. The authors present the novel case of a patient with a duplicated right PCA in parallel with fetal-type and conventional PCAs supplying adjacent components of the PCA cerebral territory.
    METHODS: A 59-year-old woman presented with a modified Fisher Scale score 4 subarachnoid hemorrhage. A right irregular PCOM aneurysm that measured 9.5 mm × 4.5 mm × 4.5 mm arose from the base of a variant branch supplying a portion of the PCA, rather than a conventional PCOM, and was found on digital subtraction angiography. Following endovascular coil embolization, the patient was discharged home.
    CONCLUSIONS: The fetal-type variant has implications for thromboembolic events. If an embolism occludes the anterior circulation in a patient with a fetal-type PCA, it may result in an infarct in the PCA territory. Awareness of cerebral arterial anatomy, including an atypical collateral supply, informs a treating team\'s latitude in tolerance of which sites must be preserved and which can be safely sacrificed. https://thejns.org/doi/10.3171/CASE23735.
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