■葡萄糖代谢受昼夜节律干扰的影响。晚餐-就寝时间间隔(DBI)是一个可访问的指标,以反映晚餐时间和昼夜节律之间的对齐。我们旨在研究DBI与2型糖尿病(T2DM)的相关性。
■7676名来自河南农村队列的成年受试者。收集了他们的人口统计信息,包括晚餐时间和就寝时间。收集空腹静脉血样品用于生化测定。采用广义线性回归模型分析DBI的影响因素。此外,结合有限三次样条模型的逻辑回归用于评估DBI和T2DM之间的关联。
■多元线性回归模型结果显示,年龄(β:-0.018,95%CI:-0.021,-0.015)与DBI呈负相关。女性(β:0.311,95%CI:0.229,0.393),初中教育(β:0.246,95%CI:0.187,0.306),高中以上学历(β:0.346,95%CI:0.259,0.433),平均月收入1000-1999人民币(0.102,95%CI:0.032,0.171),月平均收入≥2000元(β:0.164,95%CI:0.076,0.251),中等体力活动(β:0.134,95%CI:0.071,0.197),当前吸烟者(β:0.214,95%CI:0.118,0.309),目前饮酒者(β:0.099,95%CI:0.008,0.190)与DBI呈正相关。此外,DBI与T2DM显著相关(校正OR:0.910,95CI:0.845~0.979,P=0.012)。DBI长于3h与T2DM风险降低相关(校正OR:0.773,95CI:0.648-0.921,P=0.004)。
■大于3小时的DBI有利于T2DM的预防。需要进一步调查以验证该协会。
UNASSIGNED: Glucose metabolism is impacted by circadian disruption. Dinner-bedtime interval (DBI) was an accessible indicator to reflect the alignment between dinner time and circadian clock. We aimed to investigate the association of DBI with type 2 diabetes mellitus (T2DM).
UNASSIGNED: 7676 adult subjects from the Henan Rural Cohort were included. Their demographic information including dinner time and bedtime was collected. Fasting venous blood samples were collected for biochemical determinations. Generalized linear regression model was used to analyze the factors influencing DBI. Furthermore, logistic regression incorporated with restricted cubic spline model was applied to evaluate the association between DBI and T2DM.
UNASSIGNED: The results of multiple linear regression model showed that age (β: -0.018, 95% CI: -0.021, -0.015) was negatively correlated with DBI. Female (β: 0.311, 95% CI: 0.229, 0.393), junior high school education (β: 0.246, 95% CI: 0.187, 0.306), high school education or above (β: 0.346, 95% CI: 0.259, 0.433), average monthly income with 1000-1999 CNY(0.102, 95% CI: 0.032, 0.171), average monthly income ≥ 2000 CNY (β: 0.164, 95% CI: 0.076, 0.251), moderate physical activity (β: 0.134, 95% CI: 0.071, 0.197), current smokers (β: 0.214, 95% CI: 0.118, 0.309), current drinkers (β: 0.099, 95% CI: 0.008, 0.190) were positively correlated with DBI. Furthermore, DBI was significantly associated with T2DM (adjusted OR: 0.910, 95%CI: 0.845-0.979, P = 0.012). DBI longer than 3 h was associated with decreased risk of T2DM (adjusted OR: 0.773, 95%CI: 0.648-0.921, P = 0.004).
UNASSIGNED: DBI larger than 3 h is beneficial to T2DM prevention. Further investigation is required to verify the association.