PDF(Pubmed)
Abstract：
Circadian rhythms regulate physiological processes in approximately 24 h cycles, and their disruption is associated with various diseases. Inflammation may perturb circadian rhythms, though these interactions remain unclear. This study examined whether systemic inflammation induced by an intraperitoneal injection of lipopolysaccharide (LPS) could alter central and peripheral circadian rhythms and diurnal neuroimmune dynamics. Mice were randomly assigned to two groups: the saline control group and the LPS group. The diurnal expression of circadian clock genes and inflammatory cytokines were measured in the hypothalamus, hippocampus, and liver. Diurnal dynamic behaviors of microglia were also assessed. Our results revealed that the LPS perturbed circadian gene oscillations in the hypothalamus, hippocampus, and liver. Furthermore, systemic inflammation induced by the LPS could trigger neuroinflammation and perturb the diurnal dynamic behavior of microglia in the hippocampus. These findings shed light on the intricate link between inflammation and circadian disruption, underscoring their significance in relation to neurodegenerative diseases.
摘要：
昼夜节律在大约24小时的周期内调节生理过程，它们的破坏与各种疾病有关。炎症可能扰乱昼夜节律，尽管这些相互作用尚不清楚。这项研究检查了腹膜内注射脂多糖（LPS）引起的全身性炎症是否可以改变中枢和外周昼夜节律和昼夜神经免疫动力学。将小鼠随机分为两组:盐水对照组和LPS组。测定下丘脑昼夜节律基因和炎症因子的昼夜表达,海马体,还有肝脏.还评估了小胶质细胞的昼夜动态行为。我们的结果表明，LPS扰乱了下丘脑的昼夜节律基因振荡，海马体,还有肝脏.此外，LPS诱导的全身性炎症可引发神经炎症并扰乱海马小胶质细胞的昼夜动态行为。这些发现揭示了炎症和昼夜节律紊乱之间的复杂联系，强调它们在神经退行性疾病中的重要性。
