未经证实:慢性非愈合性溃疡导致显著的发病率,高成本和降低生活质量。
UNASSIGNED:比较自体富血小板纤维蛋白基质和自体非培养表皮细胞悬液移植治疗慢性非愈合性溃疡的疗效。
未经评估:这项研究是单中心的,prospective,在印度北部的三级护理中心进行的随机比较研究。纳入慢性非愈合性溃疡患者,并随机分为两个治疗组:第1组:每2周进行一次富血小板纤维蛋白基质(PRFM)手术,最多3次;第2组:自体非培养表皮细胞悬液(NCES)手术一次。每2周随访8周,然后每月随访5个月,以评估溃疡的愈合情况。数据通过社会科学统计软件包(SPSS)试用版22进行分析。为了找出组间平均值的显著差异,卡方检验,学生t检验,使用了曼-惠特尼U检验。
UNASSIGNED:共41例患者纳入研究。在5个月结束时,PRFM组中89.5%的患者和NCES组中93.8%的患者溃疡完全愈合(P=0.33)。在PRFM中,完全愈合的平均持续时间为1.7个月,在NCES中为2.13个月(P=0.20)。
未经评估:两种程序都有效,两种程序之间没有显着差异。
UNASSIGNED: Chronic non-healing ulcer causes significant morbidity, high cost and reduced quality of life.
UNASSIGNED: To compare autologous platelet-rich fibrin matrix and transplantation of autologous non-cultured epidermal cell suspension in the treatment of chronic non-healing ulcers.
UNASSIGNED: The study was single-centre, prospective, randomised comparative study conducted in a tertiary care center in North India. Patients with chronic non-healing ulcer were included and randomly divided into two treatment groups- Group 1: Platelet-rich fibrin matrix (PRFM) procedure was done every 2 weeks with maximum three sittings and in Group 2: Transplantation of autologous noncultured epidermal cell suspension (NCES) procedure was done once. Follow-up was done every 2 weeks for 8 weeks then monthly for up to 5 months to evaluate the healing of the ulcer. The data were analysed by statistical package for social science (SPSS) trial version 22. To find out a significant difference in mean value between groups, the Chi-square test, student\'s t-test, and Mann-Whitney U test were used.
UNASSIGNED: A total of 41 patients were included in the study. Complete healing of ulcers occurred in 89.5% of the patients in the PRFM group and 93.8% of the patients in the NCES group at the end of 5 months (P = 0.33). The mean duration of complete healing in PRFM was 1.7 months and in NCES was 2.13 months (P = 0.20).
UNASSIGNED: Both procedures were effective, and there was no significant difference between the two procedures.