chest wall tumors

胸壁肿瘤
  • 文章类型: Journal Article
    原发性和继发性胸壁肿瘤(骨,乳房,和软组织),先天性缺陷,胸壁放射性骨坏死通常需要广泛的全层局部切除,以确保安全的肿瘤切缘(在肿瘤的情况下)和复杂的重建,以提供稳定和良好的生物力学结果,避免术后呼吸衰竭。因此,在处理胸壁缺陷时需要个性化的方法,重建计划。这篇综述总结了失败的胸壁重建程序,确定失败的原因,并强调了复杂的胸壁重建失败后的原则。
    我们对PubMed,Scopus,ScienceDirect,和谷歌学者,包括1970年发表的所有相关研究。
    文献中的现有经验仅仅是无稽之谈,没有关于这一主题的现行指南或规则,也给了它的稀有性。适当的术前计划和多学科团队(MDT)讨论对于复杂病例至关重要,例如先前手术治疗后的感染和辐射诱发的胸溃疡。手术最终应包括胸壁清创术,坏死组织切除,脉冲喷射灌洗,假体移除,和真空辅助闭合(VAC)治疗作为胸壁重建的桥梁。胸骨切开术伤口需要去除金属丝和假体,以及使用网状物或同种异体骨移植。本文旨在总结经验,强调失败后复杂胸壁重建的外科和肿瘤学原则。
    这篇综述总结了文献经验,以确定失败后胸壁重建的共同关键点,并为处理这种罕见情况的外科医生提供一些建议,具有挑战性的手术。
    UNASSIGNED: Primary and secondary chest wall tumors (bone, breast, and soft tissue), congenital defects, and chest wall osteoradionecrosis often require extensive full-thickness local excisions to guarantee safe oncological margins (in cases of tumors) and complex reconstruction to provide stabilization and good biomechanical results avoiding postoperative respiratory failure. Thus, a personalized approach is required when dealing with chest wall defects, and reconstruction is planned. This review summarizes failed chest wall reconstruction procedures, identifies causes of failure, and highlights principles for complex chest wall reconstruction post-failure.
    UNASSIGNED: We performed a narrative review of the literature on PubMed, Scopus, ScienceDirect, and Google Scholar, including all the relevant studies published from 1970.
    UNASSIGNED: The available experiences in literature are only anecdotic and no current guidelines or rules exist on this topic, also given to its rarity. Proper pre-surgical planning and a multidisciplinary team (MDT) discussion are crucial for complex cases such as infections and radiation-induced chest ulcers after previous surgical treatment. Procedures should eventually include thoracic wall debridement, necrotic tissue excision, pulse-jet lavage, prosthesis removal, and vacuum assisted closure (VAC) therapy as a bridge for chest wall re-reconstruction. Sternotomy wounds require wire and prosthesis removal, and the use of meshes or bone allografts. This review aims to summarize experiences and highlight surgical and oncologic principles for complex chest wall reconstruction after failure.
    UNASSIGNED: This review summarizes literature experiences to identify common key points for chest wall reconstruction after failure and to give some advice to surgeons managing this rare, challenging surgery.
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  • 文章类型: Journal Article
    本研究旨在比较进行宽胸壁切除和重建或初次闭合的患者。
    在2018年1月至2022年12月期间接受胸壁切除和重建的63例患者被纳入回顾性研究。将患者分为两组:第一组,其中包括31名患者(14名男性,17名女性;平均年龄:44.6±16.4岁;范围,16至71岁)主要是关闭的,第二组,构成32名患者(25名男性,7名女性;平均年龄:54.6±17.2岁;范围,9至80岁)进行了板和网格重建。
    在吸烟和糖尿病方面,两组之间没有显着差异。33例患者确定了原发性胸壁或转移性肿瘤;30例患者确定了良性肿瘤和创伤。两组平均缺损直径的差异(p=0.009),使用的平均平板数(p<0.001),平均住院时间(p<0.001)有统计学意义。然而,在并发症方面无显著差异(p=0.426).
    与初次闭合相比,宽胸壁切除和重建是安全可行的外科手术。
    UNASSIGNED: This study aimed to compare patients in whom wide chest wall resection and reconstruction or primary closure was performed.
    UNASSIGNED: A total of 63 patients who underwent chest wall resection and reconstruction between January 2018 and December 2022 were included in the retrospective study. The patients were divided into two groups: the first group, which included 31 patients (14 males, 17 females; mean age: 44.6±16.4 years; range, 16 to 71 years) who were closed primarily, and the second group, constituting 32 patients (25 males, 7 females; mean age: 54.6±17.2 years; range, 9 to 80 years) who underwent reconstruction with plates and meshes.
    UNASSIGNED: There was no significant difference between the two groups in terms of smoking and diabetes. Primary chest wall or metastatic tumor was determined in 33 patients; benign tumor and trauma were determined in 30 patients. The difference between the two groups in mean defect diameter (p=0.009), mean number of plates used (p<0.001), and mean hospital stay (p<0.001) was statistically significant. However, there was no significant difference in terms of complications (p=0.426).
    UNASSIGNED: Wide chest wall resection and reconstruction is a safe and feasible surgical procedure when compared with primary closure.
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  • 文章类型: Journal Article
    全厚度胸壁缺损的重建具有挑战性,并且与相当大的并发症风险相关。因此,本研究的目的是探讨全厚度胸壁重建术后的手术结局及其与患者和治疗特征的关系.
    进行了一项回顾性观察性研究,包括在2014年1月至2020年12月期间在伊拉斯姆斯MC接受全层胸壁缺损重建的患者。重建的类型分为骨骼和软组织重建。对于骨骼重建,仅使用非刚性假体材料。检索患者和手术特征,并分析其与术后并发症的关系。
    32名女性和10名男性,平均年龄为60岁。在26例患者(61.9%)中,使用假体材料和软组织瓣进行重建,在9例(21.4%)中,仅使用了软组织皮瓣,在其他7名患者(16.7%)中,仅使用了假体材料。带蒂肌皮背阔肌皮瓣最常用(n=17),其次是胸大肌皮瓣(n=8)和游离皮瓣(n=8)。22例患者(52.4%)发生了至少一种术后并发症。伤口(21.4%)和肺部(19.0%)并发症最常见。5例(11.9%)患者需要再次手术。患者和治疗特征以及主要并发症的发生之间没有关联。没有死亡。
    仅使用非刚性假体材料进行骨骼重建的全厚度胸壁缺损的重建似乎是安全的,具有可接受的再手术率和低死亡率,质疑刚性固定技术的必要性。
    UNASSIGNED: Reconstruction of full thickness chest wall defects is challenging and is associated with a considerable risk of complications. Therefore, the aim of this study was to investigate the surgical outcomes and their associations with patient and treatment characteristics following full thickness chest wall reconstruction.
    UNASSIGNED: A retrospective observational study was performed by including patients who underwent reconstruction of full thickness chest wall defect at the Erasmus MC between January 2014 and December 2020. The type of reconstruction was categorized into skeletal and soft tissue reconstructions. For skeletal reconstruction, only non-rigid prosthetic materials were used. Patient and surgical characteristics were retrieved and analyzed for associations with postoperative complications.
    UNASSIGNED: Thirty-two women and 10 men with a mean age of 60 years were included. In 26 patients (61.9%), the reconstruction was performed using prosthetic material and a soft tissue flap, in nine cases (21.4%) only a soft tissue flap was used, and in seven other patients (16.7%) only the prosthetic material was used. Pedicled musculocutaneous latissimus dorsi flaps were used most often (n=17), followed by pectoralis major flaps (n=8) and free flaps (n=8). Twenty-two patients (52.4%) developed at least one postoperative complication. Wounds (21.4%) and pulmonary (19.0%) complications occurred most frequently. Five (11.9%) patients required reoperation. There were no associations between patient and treatment characteristics and the occurrence of major complications. There was no mortality.
    UNASSIGNED: Reconstruction of full thickness chest wall defects using only non-rigid prosthetic material for skeletal reconstruction appears safe with an acceptable reoperation rate and low mortality, questioning the need for rigid fixation techniques.
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  • 文章类型: Case Reports
    促纤维化瘤表现出与其他软组织肿瘤相似的程度,即使是黄金标准研究也可能错过。
    这是报告一名47岁男性的胸壁肿块,最初被认为是血管瘤,但后来在活检的帮助下被诊断为增生性纤维母细胞瘤。
    UNASSIGNED: Desmoplastic fibroma presents similar to other soft tissue tumors to such an extent that even a gold standard investigation can miss.
    UNASSIGNED: This is to report a mass in a 47-year-old male arising from the chest wall, which was first thought to be a hemangioma but was later diagnosed as a case of desmoplastic fibroblastoma with the help of a biopsy.
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  • 文章类型: Journal Article
    背景:恶性胸壁肿瘤(MCWT)的胸壁切除术,特别是那些需要重建的全厚度胸壁,为胸外科和整形外科医生提出了治疗挑战。这项研究的目的是回顾我们对原发性和转移性MCWT的胸壁切除术的经验,重点关注围手术期结局和术后总生存期(OS)。
    方法:回顾性分析2000年至2019年在我们单一机构接受原发性和继发性MCWT手术切除的所有患者。
    结果:共有42名患者(25名男性,中位年龄60岁)接受治愈性(n=37,88.1%)或姑息性(n=5,11.9%)治疗。大约33(78%)MCWT是次要来源。40例(95%)需要进行胸壁重建。共有13例(31%)患者发生术后并发症,1例(2.3%)围手术期死亡。术后5年总生存率为51.9%。继发性MCWTs患者的术后5年生存率为42.6%,明显低于原发性MCWTs患者的87.5%。
    结论:在精心挑选的患者中,原发性和继发性MCWT的胸壁切除是可行的,并且与良好的围手术期结局相关.对于二级MCWT,手术也可以姑息治疗。
    BACKGROUND: Chest wall resections for malignant chest wall tumors (MCWTs), particularly those with full-thickness chest wall involvement requiring reconstruction, present a therapeutic challenge for thoracic and plastic reconstructive surgeons. The purpose of this study was to review our experience with chest wall resection for primary and metastatic MCWTs, with a focus on perioperative outcomes and postoperative overall survival (OS).
    METHODS: All patients who underwent surgical resection for primary and secondary MCWTs at our single institution between 2000 and 2019 were retrospectively analyzed.
    RESULTS: A total of 42 patients (25 male, median age 60 years) operated upon with curative (n = 37, 88.1%) or palliative (n = 5, 11.9%) intent were reviewed. Some 33 (78%) MCWTs were of secondary origin. Chest wall reconstruction was required in 40 (95%) cases. A total of 13 (31%) patients had postoperative complications and one (2.3%) died perioperatively. The 5-year postoperative overall survival rate was 51.9%. The postoperative 5-year survival rate of 42.6% in patients with secondary MCWTs was significantly lower compared to the figure of 87.5% in patients with primary MCWTs.
    CONCLUSIONS: In well-selected patients, chest wall resections for primary and secondary MCWTs are feasible and associated with good perioperative outcomes. For secondary MCWTs, surgery can also be performed with palliative intent.
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  • 文章类型: Journal Article
    胸壁切除术用于治疗原发性和继发性肿瘤的扩展仍存在广泛争议。广泛手术后的重建策略以及胸壁拆除本身都具有挑战性。重建手术旨在避免呼吸衰竭并确保胸内器官保护。这篇评论的目的是分析有关此问题的文献,重点是胸壁重建的计划策略。这是一个叙述性的审查,报告最有趣的胸壁拆除和重建研究的数据。选择并描述了胸壁胸外科手术的代表性手术系列。我们专注于确定分析所用材料的最佳重建策略,重建技术,发病率和死亡率。如今,“刚性”和“非刚性”胸壁系统重建中的新“仿生”材料代表了治疗具有挑战性的胸部疾病的新视野。有必要进行进一步的前瞻性研究,以确定在胸部大切除术后可增强胸部功能的新材料。
    The extension of chest wall resection for the treatment of primary and secondary tumours is still widely debated. The reconstructive strategy after extensive surgery is challenging as well as chest wall demolition itself. Reconstructive surgery aims to avoid respiratory failure and to guarantee intra-thoracic organs protection. The purpose of this review is to analyse the literature on this issue focusing on the planning strategy for chest wall reconstruction. This is a narrative review, reporting data from the most interesting studies on chest wall demolition and reconstruction. Representative surgical series on chest wall thoracic surgery were selected and described. We focused to identify the best reconstructive strategies analyzing employed materials, techniques of reconstruction, morbidity and mortality. Nowadays the new \"bio-mimetic\" materials in \"rigid\" and \"non-rigid\" chest wall systems reconstructive represent new horizons for the treatment of challenging thoracic diseases. Further prospective studies are warranted to identify new materials enhancing thoracic function after major thoracic excisions.
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  • 文章类型: Case Reports
    目的:恶性胸壁肿瘤在儿科少见。它们需要多模式肿瘤治疗和局部手术控制。切除广泛;因此,应计划进行胸廓成形术以保护胸内器官,预防脑疝,未来的畸形,保持通气动力学,并启用放射治疗。
    方法:我们介绍了一系列患有恶性胸壁肿瘤的儿童病例,以及我们使用可吸收肋骨替代品(BioBridge®)进行胸部成形术的手术经验,在局部手术控制后。BioBridge®是由聚丙交酯酸共混物(70%L-乳酸y30%DL-丙交酯)制成的共聚物。
    结果:在2年内,我们有3例恶性胸壁肿瘤患者.切除边缘为阴性,随访时无复发。我们取得了良好的外观和功能效果,无术后并发症。
    结论:替代重建技术,如可吸收肋骨替代品提供保护,保证灵活的胸壁,并且不干扰辅助放疗。目前,在胸廓成形术中没有处理方案.对于胸壁肿瘤患者,此选项代表了极好的替代方案。了解不同的方法和重建原则对于为儿童提供最佳的手术选择至关重要。
    OBJECTIVE: Malignant chest wall tumors are rare in pediatrics. They require multimodal oncological treatment and local surgical control. Resections are extensive; therefore, thoracoplasty should be planned to protect intrathoracic organs, prevent herniation, future deformities, preserve ventilatory dynamics, and enable radiotherapy.
    METHODS: We present a case series of children with malignant chest wall tumors and our surgical experience with thoracoplasty using absorbable rib substitutes (BioBridge®), after local surgical control. BioBridge® is a copolymer made of a polylactide acid blend (70% L-lactic acid y 30% DL-lactide).
    RESULTS: In 2 years, we had three patients with malignant chest wall tumors. Resection margins were negative, without recurrence at follow-up. We achieved good cosmetic and functional results, and no postoperative complications.
    CONCLUSIONS: Alternative reconstruction techniques such as absorbable rib substitutes provide protection, guarantee a flexible chest wall, and do not interfere with adjuvant radiotherapy. Currently, there are no management protocols in thoracoplasty. This option represents an excellent alternative for patients with chest wall tumors. Knowledge of different approaches and reconstructive principles is essential to offer children the best onco-surgical option.
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  • 文章类型: Systematic Review
    背景:小儿胸壁肿瘤的切除会导致大的缺陷,需要重建功能和外观。已经描述了多种重建方法。我们对文献进行了系统回顾,以描述常用的方法和结果。
    方法:对英文出版物进行了系统的文献检索,这些出版物描述了在≤21岁的患者中使用可植入材料进行胸壁肿瘤切除和重建。仅排除软组织切除术,胸骨切除术,和重建通过初级修复或单独的肌肉皮瓣。收集诊断数据,重建方法,和结果。将刚性胸壁重建与网格重建进行比较。
    结果:共纳入文献55篇,共188例患者。中位年龄为12岁。大多数肿瘤是恶性的(n=172,91.5%),最常见的尤因肉瘤(n=65,34.6%),其次是未指定的肉瘤(n=34,18.1%),Askin肿瘤(n=16,8.5%;尤因肉瘤的一个子集)和骨肉瘤(n=16,8.5%)。切除3根肋骨的中位数(范围1-12)。非刚性网格最常见(n=138,73.4%),其次是刚性假体(n=50,26.6%)。术后并发症19例(16.8%),其中22.2%的患者发生脊柱侧弯。并发症无显著差异(20.5%刚性与10.6%非刚性,p=0.18)或脊柱侧凸(22.7%vs.14.0%,p=0.23)通过重建方法,但刚性重建后的并发症更可能需要手术(90.0%vs.53.9%,p=0.09)。中位随访时间为24个月。
    结论:在这篇文献综述中,重建方法在术后总体并发症或脊柱侧凸发展方面无显著差异,然而,刚性重建后的并发症更可能需要手术干预。
    方法:四级。
    BACKGROUND: Resection of pediatric chest wall tumors can result in large defects requiring reconstruction for function and cosmesis. Multiple reconstructive methods have been described. We performed a systematic review of the literature to describe commonly used approaches and outcomes.
    METHODS: A systematic literature search was performed for English-language publications describing chest wall tumor resection and reconstruction using implantable materials in patients ≤21 years, excluding soft tissue resection only, sternal resection, and reconstruction by primary repair or muscle flaps alone. Data were collected on diagnoses, reconstructive method, and outcomes. Rigid chest wall reconstruction was compared to mesh reconstruction.
    RESULTS: There were 55 articles with 188 patients included. The median age was 12 years. Most tumors were malignant (n = 172, 91.5%), most commonly Ewing\'s sarcoma (n = 65, 34.6%), followed by unspecified sarcomas (n = 34, 18.1%), Askin\'s tumor (n = 16, 8.5%; a subset of Ewing\'s sarcoma) and osteosarcoma (n = 16, 8.5%). A median of 3 ribs were resected (range 1-12). Non-rigid meshes were most common (n = 138, 73.4%), followed by rigid prostheses (n = 50, 26.6%). There were 19 post-operative complications (16.8%) and 22.2% of patients developed scoliosis. There were no significant differences in complications (20.5% rigid vs. 10.6% non-rigid, p = 0.18) or scoliosis (22.7% vs. 14.0%, p = 0.23) by reconstruction method, but complications after rigid reconstruction were more likely to require surgery (90.0% vs. 53.9%, p = 0.09). The median follow-up duration was 24 months.
    CONCLUSIONS: In this review of the literature, there were no significant differences in overall post-operative complications or scoliosis development by reconstruction method, yet complications after rigid reconstruction were more likely to require surgical intervention.
    METHODS: Level IV.
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  • 文章类型: Journal Article
    未经批准:在这项研究中,我们的目的是调查我们手术患者的背骨弹性纤维瘤形成侧与优势手之间的相关性。
    UNASSIGNED:共有84例背部弹性纤维瘤患者(12例男性,72名女性;平均年龄:55.5±7.0岁;范围,43至74年)在2007年4月至2019年5月之间进行了回顾性分析。支配的手,location,尺寸,性别,年龄,记录患者的职业和随访情况,记录患者术前和术后视觉模拟量表评分.
    未经评估:平均症状持续时间为9.5±7.8(范围,3至48)个月。病变位于右侧49例(58.3%),左侧为16例(19%),双侧为19例(22.6%)。质量大小和年龄之间没有显着差异,症状持续时间和并发症发展(p=0.129)。在优势手侧的质量形成之间发现了显着关系(p=0.010)。发现术前和术后第90天视觉模拟量表评分之间存在显着差异(p<0.001),表明疼痛评分显著下降。
    UNASSIGNED:背侧弹性纤维瘤手术切除后具有良好的临床效果。在我们的系列中,患者的优势手侧有明显更多的背侧弹性纤维瘤.
    UNASSIGNED: In this study, we aimed to investigate the correlation between the side of elastofibroma dorsi formation and the dominant-hand of the patients we operated.
    UNASSIGNED: A total of 84 patients with elastofibroma dorsi (12 males, 72 females; mean age: 55.5±7.0 years; range, 43 to 74 years) were retrospectively analyzed between April 2007 and May 2019. Dominant hand, location, size, sex, age, occupations and follow-up of the mass were recorded and the pre- and postoperative Visual Analog Scale scores were noted.
    UNASSIGNED: The mean symptom duration was 9.5±7.8 (range, 3 to 48) months. The lesions were located on the right in 49 (58.3%), on the left in 16 (19%) and bilateral in 19 (22.6%). There was no significant difference between the mass size and age, symptom duration and complication development (p=0.129). A significant relation was found between the formation of the mass on the side of the dominant hand (p=0.010). A significant difference was found between the pre- and postoperative Day 90 Visual Analog Scale scores (p<0.001), indicating a significant decrease in the pain scores.
    UNASSIGNED: Elastofibroma dorsi has good clinical results after surgical resection. In our series, the patients had significantly more elastofibroma dorsi on their dominant-hand side.
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  • 文章类型: Journal Article
    已经描述了用于胸壁重建程序的几种材料和技术:使用一种技术或一种材料的选择主要取决于外科医生的经验以及胸部缺损的定位和尺寸,当地材料的可用性,和成本。从技术角度来看,自体和异体重建是可用的,and,在这两种情况下,刚性和非刚性假体被发现。每种材料都有其特殊性,优点和缺点;因此,在计划干预时必须有信心,以预见可能的并发症并将其最小化。我们回顾了关于使用非刚性假体材料的胸壁肿瘤(恶性和非恶性)的胸壁重建的文献,注重安全结果。
    Several materials and techniques have been described for the procedure of chest wall reconstruction: the choice of using a technique or a material over another relies mainly on the surgeon\'s experience as well as thoracic defect localization and dimension, local availability of materials, and costs. From a technical point of view, autologous and alloplastic reconstruction are available, and, in both cases, rigid and non-rigid prostheses are found. Each material has its peculiarities, with advantages and disadvantages; thus, it is mandatory to be confident when planning the intervention to foresee possible complications and minimize them. We have reviewed the literature on chest wall reconstruction in chest wall tumors (both malignant and non malignant) with non-rigid prosthetic materials, focusing on safety outcomes.
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