铂类化疗药物如顺铂,卡铂,和奥沙利铂被用作卵巢恶性肿瘤的辅助或新辅助药物,子宫颈,淋巴瘤头部和颈部,和乳房。顺铂是最常用的,直到卡铂被食品和药物管理局(FDA)批准。由于严重的恶心和肾小管损伤,许多患者不耐受顺铂。卡铂用于副作用限制顺铂使用的患者。尽管卡铂与血尿最不常见,我们报道一例卡铂引起的血尿伴梗阻性急性肾损伤(AKI)。我们的病人,一名63岁的女性被诊断为三阴性乳腺癌和乳房切除术后,开始辅助化疗,卡铂700毫克和紫杉醇250毫克。她因血块导致输尿管梗阻血尿,导致阻塞性AKI。病人持续出现少尿且症状恶化,因此,输尿管上有支架.患者的肾功能恢复至基线。在这种情况下,我们强调卡铂可引起输尿管梗阻血尿。在输注卡铂和顺铂之前充分的水合可以减少并发症。
Platinum-based chemotherapeutic agents such as cisplatin, carboplatin, and oxaliplatin are used as adjuvant or neoadjuvant agents in malignancies of the ovary, cervix, lymphoma, head and neck, and breast. Cisplatin is most commonly used until the carboplatin is approved by the Food and Drug Administration (FDA). Cisplatin is not tolerated in many patients due to severe nausea and renal tubular injury. Carboplatin is used in patients where side effects limit the uses of cisplatin. Although carboplatin is least commonly associated with hematuria, we report a case of carboplatin-induced hematuria with obstructive acute kidney injury (AKI). Our patient, a 63-year-old female diagnosed with triple-negative breast carcinoma and post-mastectomy, was started on adjuvant chemotherapy, with carboplatin 700 mg and paclitaxel 250 mg. She developed hematuria with ureter obstruction due to clots, resulting in obstructive AKI. The patient continued to have oliguria and worsening symptoms, and thus, the ureter was stented. The patient\'s renal function returned to the baseline. In this case, we highlight the fact that carboplatin can cause hematuria with ureter obstruction. Adequate hydration before infusing carboplatin as in cisplatin can reduce the complications.